%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 79 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 143.73199463 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 193.40800476 23.67700005 Tm 0 Tr [(IgG\()1(H+L\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.56799316 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.83699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21099854 12.82499981 Tm [(\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.76399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.13800049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A0006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.2480011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.62200165 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.83399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.20800018 12.82499981 Tm [(\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.76100159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.21199799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00100009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 132.67500305 172.3500061 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.29499817 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.69100189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.19100189 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.19799805 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.59100342 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.66299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.16299438 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.88999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.38999939 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.477005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.977005 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.91799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.41799927 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.44299316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.51000023 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00999832 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.10499954 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.60499954 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.16600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.66600037 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1269989 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.60899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.10899353 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.51699829 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.18299866 42.92200089 Tm [(mic)-1(r)1(oorg)1(anis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.59899998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.09900093 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.37599945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.87599945 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.8769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3769989 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.76000214 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.26000214 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.27799988 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.86300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.36300659 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.375 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.52200317 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.0269928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.5269928 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.66799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.16799927 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.14300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.64300537 58.52199936 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(art)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.76399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.26399994 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.1060009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6060009 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.31000137 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81000137 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.84300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.34300232 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.80200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30200195 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.46600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.96600342 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.772995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.272995 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.36799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.86799622 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.08500671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.58499146 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.26699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.76699829 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(wo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 89.72200012 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.19400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.69400024 89.72200012 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.76699829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.26699829 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.34200287 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.84200287 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.28799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.78799438 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.86300659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.36300659 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.36399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.86399841 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.61199951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.11199951 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33399963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.83399963 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.85501099 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.35501099 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 105.3219986 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.14500046 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.64500046 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.92199707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.42199707 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.49700165 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.99700165 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.78399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.28399658 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.44299316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.94299316 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.51899719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.01899719 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.29600525 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.79600525 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.17900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.67900085 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.7539978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.2539978 105.3219986 Tm [(dest)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(oy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.48499966 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.98499966 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.98600006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.48600006 120.92199707 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.33000183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.83000183 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.63700104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.13700104 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.69200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.19200134 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.03399658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.53399658 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.53500366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.03500366 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.13000488 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.63000488 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.21600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.71600342 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.2769928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.7769928 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.92001343 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.42001343 120.92199707 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 136.52200317 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.82099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.32099915 136.52200317 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.21099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.71099854 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.98800659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.48800659 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.48899841 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.98899841 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80499268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.30499268 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.14700317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.64700317 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.51998901 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.46099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.96099854 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.48199463 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.88399887 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.38399887 152.12199402 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.7120018 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.2120018 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.18699646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.68699646 152.12199402 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.21499634 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.71499634 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.00299835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.50299835 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.26699829 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.76699829 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.32800293 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.82800293 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.4730072 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.9730072 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.04800415 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.54800415 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.4019928 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.9019928 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.01300049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.51300049 152.12199402 Tm [(var)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nts.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.23099995 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 132.67500305 31.95000076 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Opt)1(imal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 11.72200012 Tm [(test)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.97499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.47499847 11.72200012 Tm [(ap)1(plic)-1(at)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [(wo)1(rk)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 11.72200012 Tm [(dilutions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81799316 11.72200012 Tm [(must)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.31599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.81599426 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17001343 11.72200012 Tm [(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(termined)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.63299942 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.14500046 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.64500046 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.64600372 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.14600372 27.3220005 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.55500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.05500031 27.3220005 Tm [(user.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.47599792 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 0.75 m 132.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 173.1000061 m 132.30000305 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q q 1 0 0 1 0 445.14498901 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 473.08401489 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 501.02301025 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 528.9619751 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 556.90100098 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 584.84002686 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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