%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n q 1 0 0 1 0 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q BT /FAAAAI 9 Tf 1 0 0 -1 271.5 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.41400146 23.67700005 Tm 0 g [(ZPBP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 145.18099976 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 321.88500977 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(ZPBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.47699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.72699738 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 173.727005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZPBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.47699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.85099792 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.0530014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.42700195 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.40699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.78100586 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.25500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(zon)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.23100281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.60500336 12.82499981 Tm [(pell)-1(uci)-1(da)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.07800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.45200348 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.27999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.65400696 12.82499981 Tm [(protein)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.84599304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.22000122 12.82499981 Tm [(ZPBP)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.01899719 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(45-35)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(ZPBP)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 329.65301514 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 333.77301025 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(zo)1(n)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.66699982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.16699982 11.72200012 Tm [(pelluc)-1(ida)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.99700165 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.49700165 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.64099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.14099884 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.44799805 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ZPBP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.5189991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(S86)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.00899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(05)-1(22)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.17500305 16.35000038 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 115.42500305 0.75 l 115.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 116.42500305 -0.25 l 116.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.17500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 116.17500305 78.75 l h f* Q q 1 0 0 1 115.80000305 0 cm -0.625 -0.25 m 307.625 -0.25 l 307.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ZPBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.24099922 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.74099922 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.30199814 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.80199814 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.17599869 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.67599869 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.51799774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.01799774 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.42700195 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.8999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.3999939 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.62199402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.12199402 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.63999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.13999939 11.72200012 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.95300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.45300293 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.52799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.02799988 11.72200012 Tm [(pa)1(rticipat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.02600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.52600098 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.4670105 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(sec)-1(o)1(n)-1(d)1(ary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.98500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.48500061 27.3220005 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.6289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.1289978 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.2009964 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.7009964 27.3220005 Tm [(acroso)1(me)-1(-)1(re)-1(a)1(c)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.91499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.41499329 27.3220005 Tm [(sperm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.30499268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80499268 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.08200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.58200073 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.58300781 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.08300781 27.3220005 Tm [(egg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(-sp)1(e)-1(cific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.85100174 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.35100174 42.92200089 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.54499817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.04499817 42.92200089 Tm [(mat)1(rix,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.36499786 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.86500549 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.86599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.36599731 42.92200089 Tm [(zo)1(n)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.03300476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.53300476 42.92200089 Tm [(pelluc)-1(ida)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.36300659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.86300659 42.92200089 Tm [(\(Mc)-1(Leske)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.83700562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.33700562 42.92200089 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.79598999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.29598999 42.92200089 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.99899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(19)-1(98)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.11100006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.61100006 58.52199936 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.0739975 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.5739975 58.52199936 Tm [(93)-1(78)-1(61)-1(8]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.6969986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.1969986 58.52199936 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.72900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.22900391 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.08299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.58299255 58.52199936 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.65299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.15299988 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.09399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.59399414 58.52199936 Tm [(ga)1(me)-1(t)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.32400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.82400513 58.52199936 Tm [(interactio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 74.12200165 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.48300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.98300171 74.12200165 Tm [(fert)1(i)-1(liz)1(ation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.76599884 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 0.75 m 115.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 17.10000038 m 115.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 33.45000076 m 115.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 49.80000305 m 115.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 66.15000153 m 115.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 82.5 m 115.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 98.84999847 m 115.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.80000305 115.19999695 m 115.80000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 423.17498779 193.57499695 l S Q Q q 1 0 0 1 0 586.86199951 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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