%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 114 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.26899719 23.67700005 Tm 0 g [(ZNF47)1(3)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.32600403 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 333.02999878 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(ZNF473)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48400116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 100.73400116 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.73399353 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZNF473)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48400116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.85800171 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.05999756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.43400574 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.41400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.78799438 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.26199341 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(zi)-1(nc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88800049 12.82499981 Tm [(fi)-1(nge)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.84600067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.22000122 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.602005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.97599792 12.82499981 Tm [(473;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.125 12.82499981 Tm [(ZN47)1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.59399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.96800232 12.82499981 Tm [(HZF)-1(P)1(100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.64100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 273.63400269 m 416.75 273.63400269 l 416.75 291.57299805 l -1.45000005 291.57299805 l h f* Q q 1 0 0 1 0 273.63400269 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 149.35800171 1.25 l 149.35800171 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 149.35800171 1.25 m 152.02099609 1.25 l 152.02099609 16.68799973 l 149.35800171 16.68799973 l h f* Q q /GS2 gs 1 g 152.02099609 1.25 m 187.66099548 1.25 l 187.66099548 16.68799973 l 152.02099609 16.68799973 l h f* Q q /GS2 gs 1 g 187.66099548 1.25 m 190.32398987 1.25 l 190.32398987 16.68799973 l 187.66099548 16.68799973 l h f* Q q /GS2 gs 1 g 190.32400513 1.25 m 206.15701294 1.25 l 206.15701294 16.68799973 l 190.32400513 16.68799973 l h f* Q q /GS2 gs 1 g 206.15699768 1.25 m 208.81999207 1.25 l 208.81999207 16.68799973 l 206.15699768 16.68799973 l h f* Q q /GS2 gs 1 g 208.82000732 1.25 m 235.89001465 1.25 l 235.89001465 16.68799973 l 208.82000732 16.68799973 l h f* Q q /GS2 gs 1 g 235.88999939 1.25 m 238.55299377 1.25 l 238.55299377 16.68799973 l 235.88999939 16.68799973 l h f* Q q /GS2 gs 1 g 238.55299377 1.25 m 260.35900879 1.25 l 260.35900879 16.68799973 l 238.55299377 16.68799973 l h f* Q q /GS2 gs 1 g 260.35900879 1.25 m 263.02200317 1.25 l 263.02200317 16.68799973 l 260.35900879 16.68799973 l h f* Q q /GS2 gs 1 g 263.02200317 1.25 m 271.86401367 1.25 l 271.86401367 16.68799973 l 263.02200317 16.68799973 l h f* Q q /GS2 gs 1 g 271.86401367 1.25 m 274.52700806 1.25 l 274.52700806 16.68799973 l 271.86401367 16.68799973 l h f* Q q /GS2 gs 1 g 274.52700806 1.25 m 304.56799316 1.25 l 304.56799316 16.68799973 l 274.52700806 16.68799973 l h f* Q q /GS2 gs 1 g 304.56799316 1.25 m 307.23098755 1.25 l 307.23098755 16.68799973 l 304.56799316 16.68799973 l h f* Q q /GS2 gs 1 g 307.23098755 1.25 m 340.74398804 1.25 l 340.74398804 16.68799973 l 307.23098755 16.68799973 l h f* Q EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.35800171 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.02099609 12.89099979 Tm [(terminal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.66099548 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.32400513 12.89099979 Tm [(20)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.15699768 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.82000732 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.88999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.55299377 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.35900879 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.02200317 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.86401367 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.52700806 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.56799316 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.23098755 12.89099979 Tm [(ZNF4)-1(73)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.74398804 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 291.57299805 m 416.75 291.57299805 l 416.75 322.77301025 l -1.45000005 322.77301025 l h f* Q q 1 0 0 1 0 291.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 322.77301025 m 416.75 322.77301025 l 416.75 353.97302246 l -1.45000005 353.97302246 l h f* Q q 1 0 0 1 0 322.77301025 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 353.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 381.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.87899971 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.37899971 11.72200012 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.74000168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.24000168 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.54699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.04699707 11.72200012 Tm [(47)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.87999725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ZN4)-1(73;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.89800072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.39799881 11.72200012 Tm [(HZ)-1(FP100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.06099701 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WTR7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.08300018 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(18)-1(61)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 140.17500305 78.75 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.61999893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.11999893 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06100082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.56100082 11.72200012 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.39099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.89099884 11.72200012 Tm [(3')-1(-)1(e)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77899933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.27899933 11.72200012 Tm [(pre-mR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.42199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.92199707 11.72200012 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.47799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.97799683 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.49000549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.99000549 11.72200012 Tm [(asso)1(c)-1(iat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.59400177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.09400177 27.3220005 Tm [(U7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.0909996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.5909996 27.3220005 Tm [(snRNP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.0019989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.5019989 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.77899933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.27899933 27.3220005 Tm [(interacting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.65400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.15400696 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.55000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05000305 27.3220005 Tm [(SLB)-1(P/pr)1(e)-1(-)1(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.0039978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.5039978 27.3220005 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mplex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4109993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9109993 42.92200089 Tm [(Inc)-1(r)1(e)-1(as)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.5719986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.0719986 42.92200089 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.90200043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.40200043 42.92200089 Tm [(3')-1(-)1(e)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.28999329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.78999329 42.92200089 Tm [(pre-mR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.43299866 42.92200089 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.98899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.48899841 42.92200089 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.13598633 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.63598633 42.92200089 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 58.52199936 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.9090004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.4090004 58.52199936 Tm [(effec)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.72800064 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.22800064 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.4960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.9960022 58.52199936 Tm [(U7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.99299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.49299622 58.52199936 Tm [(snRNP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.90399933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.40399933 58.52199936 Tm [(leve)-1(ls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.46400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.96400452 58.52199936 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.26400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.76400757 58.52199936 Tm [(overexpressed.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.07400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.57400513 58.52199936 Tm [(Requi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.30000019 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.79999924 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.07799911 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.57799911 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.98799896 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.48799896 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.77999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.27999878 74.12200165 Tm [(pro)1(gression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.48100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.98100281 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.69200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.19200134 74.12200165 Tm [(G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.16299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.66299438 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.73800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.23800659 74.12200165 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.43200684 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.93200684 74.12200165 Tm [(ph)1(ases.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.80099487 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 0.75 m 139.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 17.10000038 m 139.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 33.45000076 m 139.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 49.80000305 m 139.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 66.15000153 m 139.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 82.5 m 139.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 98.84999847 m 139.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 115.19999695 m 139.80000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 423.17498779 193.57499695 l S Q Q q 1 0 0 1 0 575.86199951 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 603.80102539 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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