%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 125 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.09500122 23.67700005 Tm 0 g [(ZNF22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.50100708 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.50100708 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.20498657 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(ZNF22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.16300201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.41300201 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.41299438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZNF22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.16300201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.53700256 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.73899841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.11300659 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.09300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.46699524 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.94099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(zi)-1(nc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88800049 12.82499981 Tm [(fi)-1(nge)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.84600067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.22000122 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.602005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.97599792 12.82499981 Tm [(22;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.42900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.80299377 12.82499981 Tm [(KOX15)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.11300659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.48699951 12.82499981 Tm [(HKR-T1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.647995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.02200317 12.82499981 Tm [(ZNF422;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.31600952 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.69000244 12.82499981 Tm [(Zfp)-1(422)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.29299927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(104-2)1(24)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(ZNF22)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 339.0880127 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 333.77301025 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.87899971 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.37899971 11.72200012 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.74000168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.24000168 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.54699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.04699707 11.72200012 Tm [(22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.60299683 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(KOX15)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.57500076 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.07500076 11.72200012 Tm [(HKR-T1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.1210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.6210022 11.72200012 Tm [(ZNF4)-1(22)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.30000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.80000305 11.72200012 Tm [(Zfp)1(4)-1(22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.08299255 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P17)-1(02)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(10)-1(64)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 134.17500305 16.35000038 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 133.42500305 0.75 l 133.42500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 134.42500305 -0.25 l 134.42500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.17500305 0.75 m 422.42498779 0.75 l 422.42498779 47.54999924 l 134.17500305 47.54999924 l h f* Q q 1 0 0 1 133.80000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Bi)-1(nd)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.51099968 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.01099968 11.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.51599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 11.72200012 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.91300201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.41300201 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.41400146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.91400146 11.72200012 Tm [(conse)-1(nsus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.39100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.89100647 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.73800659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.23800659 11.72200012 Tm [(5')-1(-)1(CAATG)1(-3)-1('.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.89898682 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.39898682 11.72200012 Tm [(Ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.11800003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.61800003 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.48699951 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.4280014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.9280014 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.88200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.38200378 27.3220005 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.61300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.11300659 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.38999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.88999939 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.06100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.56100464 27.3220005 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.44200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.94198608 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.91699219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.41699219 27.3220005 Tm [(rol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.04700089 42.92200089 Tm [(to)1(oth)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.73799896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.23799896 42.92200089 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.94000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.44000244 42.92200089 Tm [(\(By)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.85700226 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.35700226 42.92200089 Tm [(similarit)1(y)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.23599243 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 0.75 m 133.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 17.10000038 m 133.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 33.45000076 m 133.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 49.80000305 m 133.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 66.15000153 m 133.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 82.5 m 133.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 98.84999847 m 133.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.80000305 115.19999695 m 133.80000305 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 423.17498779 162.375 l S Q Q q 1 0 0 1 0 555.6619873 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 583.60101318 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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