%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.79299927 23.67700005 Tm 0 g [(YY)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.80299377 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 141.80299377 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 318.50698853 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(YY)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55500031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.80500031 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.80499268 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(YY)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55500031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.92900085 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.1309967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.50499725 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.48500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.85899353 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.33299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(YY)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55500031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.92900085 12.82499981 Tm [(transcripti)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.76699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.14100647 12.82499981 Tm [(factor;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.33900452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.71299744 12.82499981 Tm [(DE)-1(LTA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.71600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.08999634 12.82499981 Tm [(NF-E1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.16499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53900146 12.82499981 Tm [(UCRBP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.52099609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.89498901 12.82499981 Tm [(IN)1(O)-1(8)1(0S)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.54800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.92199707 12.82499981 Tm [(YIN-YAN)1(G-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 353.80700684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(215-4)1(14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(YY)-1(1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 329.13900757 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 182.07499695 16.35000038 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(YY)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.14100075 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.64100075 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.22499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.72499847 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.84400177 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 182.07499695 16.35000038 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DELTA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.08099937 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.58100128 11.72200012 Tm [(NF-E1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.96500015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.46499634 11.72200012 Tm [(UCR)1(B)-1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.40000153 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.90000153 11.72200012 Tm [(INO80)-1(S;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.11300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.61300659 11.72200012 Tm [(YI)1(N-YA)1(NG-)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.84599304 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 182.07499695 16.35000038 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P25)-1(49)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 182.07499695 16.35000038 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(37)-1(30)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 182.07499695 31.95000076 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(DS-)1(PAGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.42300034 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 182.07499695 16.35000038 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 182.07499695 16.35000038 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 181.32499695 0.75 l 181.32499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 182.32499695 -0.25 l 182.32499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.07499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 182.07499695 94.34999847 l h f* Q q 1 0 0 1 181.69999695 0 cm -0.625 -0.25 m 245.4750061 -0.25 l 245.4750061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(YY)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.14100075 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.64100075 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.20199966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.70199966 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.67699814 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.17699814 11.72200012 Tm [(ubiquito)1(usly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.50900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.00900269 11.72200012 Tm [(dist)1(ributed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.52200317 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.60600281 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.7250061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(belonging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.97200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.47200012 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.54700089 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.04700089 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.04799652 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.54799652 27.3220005 Tm [(GLI-)1(Kruppel)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.59100342 27.3220005 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.80599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.30599976 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.147995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.647995 27.3220005 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.5269928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.0269928 27.3220005 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.38800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.88800049 27.3220005 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(ins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.45499992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.95500183 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.76200104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.26200104 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.56900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.06900024 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.62999725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.12999725 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.49899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.99899292 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.94000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.44000244 42.92200089 Tm [(repressing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.30400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.80400085 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.08099365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.58099365 42.92200089 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ivat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.14500046 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.64500046 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61999893 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11999893 58.52199936 Tm [(diverse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.81099701 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31099701 58.52199936 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.1269989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.6269989 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.46900177 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.96899414 58.52199936 Tm [(pro)1(moters.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.25900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.75900269 58.52199936 Tm [(YY)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.8999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.3999939 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.57099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.07099915 58.52199936 Tm [(dir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ec)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.97299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.47299957 74.12200165 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.3030014 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.8030014 74.12200165 Tm [(deace)-1(t)1(yl)-1(a)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.18499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.68499756 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.96200562 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.46200562 74.12200165 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.29200745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.79200745 74.12200165 Tm [(ace)-1(t)1(yl)-1(t)1(ransf)1(e)-1(ra)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.84700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34700012 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.3219986 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.8219986 89.72200012 Tm [(pro)1(moter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.77899933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.27899933 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.22000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.72000122 89.72200012 Tm [(ord)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.1780014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.6780014 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.75300598 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.25300598 89.72200012 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.64700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.14700317 89.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.30499268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80499268 89.72200012 Tm [(repress)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.97099304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.47099304 89.72200012 Tm [(th)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 0.75 m 181.69999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 17.10000038 m 181.69999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 33.45000076 m 181.69999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 49.80000305 m 181.69999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 66.15000153 m 181.69999695 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 98.1000061 m 181.69999695 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 114.45000458 m 181.69999695 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 181.69999695 130.80000305 m 181.69999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>