%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.32700348 23.67700005 Tm 0 g [(XRCC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.26899719 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.26899719 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.97299194 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(XRCC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.91999817 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.91999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XRCC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.04399872 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.2460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.61999512 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.6000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.97399902 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.44799805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(X-ray)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.10700226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.48100281 12.82499981 Tm [(re)1(p)-1(air)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98200226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.35600281 12.82499981 Tm [(cr)1(o)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.20700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.58099365 12.82499981 Tm [(compl)-1(e)1(menti)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.61099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.98500061 12.82499981 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.49000549 12.82499981 Tm [(SS)-1(MED)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.70300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-336)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(XRCC4)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 330.39898682 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 186.625 16.35000038 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(X-r)1(ay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.87400055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.37400055 11.72200012 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.97100067 11.72200012 Tm [(cross)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.97399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.47399902 11.72200012 Tm [(compleme)-1(nting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.52799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.02799988 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.30599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 186.625 16.35000038 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SSMED)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.98600006 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 186.625 16.35000038 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q13)-1(42)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 186.625 16.35000038 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(16)-1(31)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 186.625 31.95000076 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(DS-)1(PAGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.42300034 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 186.625 16.35000038 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 186.625 16.35000038 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 185.875 0.75 l 185.875 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 186.875 -0.25 l 186.875 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 186.625 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 186.625 94.34999847 l h f* Q q 1 0 0 1 186.25 0 cm -0.625 -0.25 m 240.92500305 -0.25 l 240.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.01199341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.51199341 11.72200012 Tm [(to)1(geth)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.43899918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.93899918 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.44400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.94400024 27.3220005 Tm [(ligas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.73799896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.23799896 27.3220005 Tm [(IV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.97000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.47000122 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.74700165 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.24700165 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.2480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.7480011 27.3220005 Tm [(DNA)1(-dependent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.17199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.67199707 27.3220005 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.70999908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.20999908 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.15100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.65100098 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.65200043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.15200043 42.92200089 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.24900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.74900055 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.59100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.09100342 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.59599304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.09599304 42.92200089 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.4960022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.9960022 42.92200089 Tm [(br)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(eak)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.31299973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.81299973 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.07500076 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.57500076 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.88200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.38200378 58.52199936 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.42900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.92900085 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.90399933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.40399933 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.06399536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.00500488 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.3690033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.8690033 58.52199936 Tm [(non-ho)1(molo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(go)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.19000053 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.69000053 74.12200165 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.09899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.59899902 74.12200165 Tm [(joining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.36299896 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.86299896 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.13999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.63999939 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.64099884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.14099884 74.12200165 Tm [(completion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.07400513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.57400513 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.41600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.91600037 74.12200165 Tm [(V\(D\)J)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.43400574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.93400574 74.12200165 Tm [(rec)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mbinat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.27899933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.77899933 89.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.62799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.12799835 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.06900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.56900024 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.02500153 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.5249939 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.04100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.54100037 89.72200012 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.57499695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.07499695 89.72200012 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.3809967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.8809967 89.72200012 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.1000061 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 0.75 m 186.25 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 17.10000038 m 186.25 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 33.45000076 m 186.25 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 49.80000305 m 186.25 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 66.15000153 m 186.25 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 98.1000061 m 186.25 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 114.45000458 m 186.25 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 186.25 130.80000305 m 186.25 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>