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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.6210022 23.67700005 Tm 0 g [(XPO6)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.9750061 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.6789856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(XPO6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.14800262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.39800262 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.397995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XPO6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.14800262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.52200317 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.72399902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.09799957 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.07800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45199585 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.92599487 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(exportin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.93000031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.30400085 12.82499981 Tm [(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.80899811 12.82499981 Tm [(EXP6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.94200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.31599426 12.82499981 Tm [(RAN)1(BP2)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.6499939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 57.37799835 l -0.75 57.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(926-1)1(125)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.54100037 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.57600403 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.61700439 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65200806 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.08300781 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.11801147 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.61099243 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.64599609 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.33200073 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.36700439 12.04500008 Tm [(XPO6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.20800781 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 5.4000001 28.43899918 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 56.37799835 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 56.37799835 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 56.62799835 m 426.3500061 56.62799835 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 358.45098877 m 416.75 358.45098877 l 416.75 389.65100098 l -1.45000005 389.65100098 l h f* Q q 1 0 0 1 0 358.45098877 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 389.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 417.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(expor)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.86800003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.36800003 11.72200012 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.64599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(EXP6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.70400047 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20400047 11.72200012 Tm [(RA)1(NB)-1(P20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.43800354 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(QU)1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.22200012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(14)-1(07)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 100.42500305 16.35000038 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 100.42500305 78.75 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(impor)1(tin-bet)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.35198975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24799919 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.7480011 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.53800201 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.03800201 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.87999725 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.37999725 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.83599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33599854 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.41799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.91799927 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.43600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.93600464 27.3220005 Tm [(regulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.36799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.86799622 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.38000488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.88000488 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.8809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.3809967 27.3220005 Tm [(GTPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.98599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.48599243 27.3220005 Tm [(Ran)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.88198853 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.38198853 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.45700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.125 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.625 42.92200089 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.36000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.86000061 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.70200348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.20200348 42.92200089 Tm [(cargo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.60500336 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.10500336 42.92200089 Tm [(across)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.08299255 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.58299255 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.58399963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.08399963 42.92200089 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.602005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.102005 42.92200089 Tm [(en)-1(v)1(e)-1(lop)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.7230072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.22299194 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.48498535 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.98498535 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.29199219 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.68200016 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18199921 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.68899918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.18899918 58.52199936 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.26999664 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.76999664 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.84500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.34500122 58.52199936 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.47000122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.97000122 58.52199936 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.48800659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.98800659 58.52199936 Tm [(expor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.91499329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.41499329 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.25700378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.75700378 58.52199936 Tm [(pro)1(filin-actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.19000244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.69000244 58.52199936 Tm [(complexe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 74.12200165 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.16600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.66600037 74.12200165 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.22699738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.72699738 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.56900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06900024 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52500153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.02500153 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.54100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.04100037 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.602005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.102005 74.12200165 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.92300415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.42300415 74.12200165 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.69099426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.19099426 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.19200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.69200134 74.12200165 Tm [(long)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.11099243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.61099243 74.12200165 Tm [(arm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.45498657 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.95498657 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.79699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.29699707 74.12200165 Tm [(chromo)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 0.75 m 100.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 17.10000038 m 100.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 33.45000076 m 100.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 49.80000305 m 100.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 66.15000153 m 100.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 82.5 m 100.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 98.84999847 m 100.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 115.19999695 m 100.05000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 423.17498779 193.57499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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