%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.95500183 23.67700005 Tm 0 g [(XKR6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.63999939 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.63999939 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.34399414 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(XKR6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.9280014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.1780014 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.17799377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XKR6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.9280014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30200195 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.5039978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.87799835 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.23199463 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.70599365 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XK,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.52500153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.61699677 12.82499981 Tm [(Ke)1(l)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20800018 12.82499981 Tm [(bl)-1(oo)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.72499847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.81700134 12.82499981 Tm [(gr)1(o)-1(up)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.99000549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.08200073 12.82499981 Tm [(compl)-1(e)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.14500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.23699951 12.82499981 Tm [(su)-1(bun)-1(it-re)1(l)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.13400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.22601318 12.82499981 Tm [(famil)-1(y,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.03900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.13101196 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.53201294 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.62399292 12.82499981 Tm [(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.75500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 353.84698486 12.82499981 Tm [(XRG6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 379.75299072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.84500122 12.82499981 Tm [(C8orf5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29901123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(C8orf7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.45400047 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.82799911 30.49699783 Tm [(C8orf21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.79399872 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(150)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(XKR6)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 276.67599487 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 160.875 31.95000076 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(XK,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.68500042 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.18499947 11.72200012 Tm [(Kell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.79399872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.29399872 11.72200012 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.63700104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.13700104 11.72200012 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.34600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.84600067 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.32499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.82499695 11.72200012 Tm [(subunit-)1(re)-1(lat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.14700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.64700317 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.89500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.39500427 11.72200012 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mber)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.72400093 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.22400093 27.3220005 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.5019989 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(XRG6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.81800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.31800079 11.72200012 Tm [(C8orf5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.83899689 11.72200012 Tm [(C8orf7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.86000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 11.72200012 Tm [(C8orf21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.49200439 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q5GH7)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.8219986 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(24)-1(14)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 160.875 31.95000076 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 129.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 145.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 160.875 63.15000153 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(XK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.51799965 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01799965 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.57900047 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.07900047 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.55400085 11.72200012 Tm [(44)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.38700104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.88700104 11.72200012 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.95700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.45700073 11.72200012 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.09700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.59700012 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.90400696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.40400696 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.62600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.12600708 11.72200012 Tm [(spa)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.727005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.227005 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.22799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.72799683 11.72200012 Tm [(membran)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.16200066 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.66200066 27.3220005 Tm [(times)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.11600113 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.61600113 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.89299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.39299774 27.3220005 Tm [(carries)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.42099762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.92099762 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.92199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.42199707 27.3220005 Tm [(ubiquito)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.59500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.09500122 27.3220005 Tm [(antig)1(e)-1(n,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.93899536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.43899536 27.3220005 Tm [(Kx,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.88000488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.38000488 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.47698975 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(determine)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.40599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.90599823 42.92200089 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.24900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.74900055 42.92200089 Tm [(type.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.88700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.38700104 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.69400024 42.92200089 Tm [(XK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.21200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.71200562 42.92200089 Tm [(\(X-linke)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.51600647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.01600647 42.92200089 Tm [(Kx)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.28999329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.78999329 42.92200089 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.13299561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.63299561 42.92200089 Tm [(gr)1(ou)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(p\)-)1(rel)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.77600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.27600098 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.79199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.29199982 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.37400055 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.87400055 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.39199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.89199829 58.52199936 Tm [(ho)1(mologs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.3500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.8500061 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.69200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.19200134 58.52199936 Tm [(XK.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.8769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.3769989 58.52199936 Tm [(XKR6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.04800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.54800415 58.52199936 Tm [(\(XK-)1(re)-1(l)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 0.75 m 160.5 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 32.70000076 m 160.5 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 49.05000305 m 160.5 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 65.40000153 m 160.5 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 81.75 m 160.5 112.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 113.69999695 m 160.5 129.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 130.05000305 m 160.5 145.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 146.40000916 m 160.5 208.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 113.32499695 m 426.17498779 113.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 129.67500305 m 426.17498779 129.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 146.02500916 m 426.17498779 146.02500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17501831 m 426.92498779 209.17501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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