%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.43099976 23.67700005 Tm 0 g [(WW)-1(P1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.16499329 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.16499329 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.86898804 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(WW)1(P1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.67900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.92900085 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.92900085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WW)1(P1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.42900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.8030014 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.00500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3789978 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.35899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.73300171 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.20700073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WW)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.68299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.05699921 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.45400238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.82800293 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.66299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.03700256 12.82499981 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.48599243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.86000061 12.82499981 Tm [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.18899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.56300354 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.94500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.31900024 12.82499981 Tm [(li)-1(gase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.44100952 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.81500244 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.9460144 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.32000732 12.82499981 Tm [(AIP)1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.59698486 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.9710083 12.82499981 Tm [(Ti)-1(ul)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.55499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.9289856 12.82499981 Tm [(hS)-1(DRP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.17700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.32099915 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.35600281 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.3809967 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.06599426 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.10099792 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.14199829 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.17700195 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.60800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64300537 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.13600159 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.17100525 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.85699463 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.89199829 12.04500008 Tm [(WW)1(P1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 284.11700439 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 166.92500305 16.35000038 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WW)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.31599998 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.81599998 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.64300156 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.14300156 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.88999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.38999939 11.72200012 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.61599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.11599731 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.79699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.29699707 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.60400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.10400391 11.72200012 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.897995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.397995 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.67599487 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 166.92500305 16.35000038 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AIP)1(5)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.92900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.42900085 11.72200012 Tm [(Tiu)-1(l1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.36800003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.86800003 11.72200012 Tm [(hSDR)1(P1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.1190033 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 166.92500305 16.35000038 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(0M0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.92200089 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 166.92500305 16.35000038 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(36)-1(06)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 166.92500305 31.95000076 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(AG)1(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.97400093 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 166.92500305 16.35000038 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 166.92500305 16.35000038 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 166.17500305 0.75 l 166.17500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 167.17500305 -0.25 l 167.17500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.92500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 166.92500305 94.34999847 l h f* Q q 1 0 0 1 166.55000305 0 cm -0.625 -0.25 m 260.625 -0.25 l 260.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WW)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.31599998 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.81599998 11.72200012 Tm [(do)1(main-c)-1(o)1(ntaining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.28399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.78399658 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.25700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.75700378 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.7749939 11.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.46499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.96499634 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.40600586 11.72200012 Tm [(all)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.17100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.67100525 11.72200012 Tm [(eu)-1(kar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(yotes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.11100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.61100006 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.38800049 27.3220005 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.26899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.76899719 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.29000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.79000092 27.3220005 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.75100708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.25100708 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.91099548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.41099548 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.352005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.852005 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.85299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.35299683 27.3220005 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.58399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.08399963 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.92599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.42599487 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.40100098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.36400032 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.86400032 42.92200089 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.61700058 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.11700058 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.95899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.45899963 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.22100067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.72100067 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.62800598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.12800598 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.89500427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.39500427 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.53599548 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.03599548 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.34300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.84300232 42.92200089 Tm [(degra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(da)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.91399956 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.41400146 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.16500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.66500092 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.94200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.44200134 58.52199936 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.96699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.46699524 58.52199936 Tm [(splicin)-1(g)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.54899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.04899597 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.31100464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.81100464 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.32699585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.82699585 58.52199936 Tm [(en)-1(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(des)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02900028 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52899933 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.50399971 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.00399971 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.31100082 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.81099701 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.90799713 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.40799713 74.12200165 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.6230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.1230011 74.12200165 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.40100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.90100098 74.12200165 Tm [(ta)1(n)-1(d)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.07099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.57099915 74.12200165 Tm [(WW)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.88699341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.38699341 74.12200165 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.38000488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.88000488 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.27799988 89.72200012 Tm [(HECT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.36700058 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.86700058 89.72200012 Tm [(\(ho)1(mologo)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.59799957 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.09799957 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.17299652 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.67300415 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.67399597 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.17399597 89.72200012 Tm [(E6-as)1(soc)-1(ia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.42100525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.92100525 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.22799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.72799683 89.72200012 Tm [(c)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 0.75 m 166.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 17.10000038 m 166.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 33.45000076 m 166.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 49.80000305 m 166.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 66.15000153 m 166.55000305 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 98.1000061 m 166.55000305 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 114.45000458 m 166.55000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.55000305 130.80000305 m 166.55000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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