%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.88899994 23.67700005 Tm 0 g [(WSB)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.70700073 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.70700073 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.41101074 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WSB2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.1989975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 93.4489975 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.44900513 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WSB2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.1989975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.57299805 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.77500153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.14900208 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.1289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.50300598 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.977005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.17500305 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.72200012 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.78500366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.15899658 12.82499981 Tm [(SO)-1(CS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.35899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.73300171 12.82499981 Tm [(bo)-1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.33399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.70799255 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.54299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.91700745 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.04800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.42199707 12.82499981 Tm [(SBA2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.35499573 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(255-4)1(04)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(WSB2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 337.40499878 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.01599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.51599884 11.72200012 Tm [(SOCS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.26000214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.76000214 11.72200012 Tm [(bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.79100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.29100037 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.03799438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.53799438 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.81599426 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SB)-1(A)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.45199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9NYS7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.83300018 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(88)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 132.125 94.34999847 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(WD)1(-pr)1(otein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.49099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.99099731 11.72200012 Tm [(subf)1(amily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.19900513 11.72200012 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.11299896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61299896 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41999817 27.3220005 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.63500214 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.13499451 27.3220005 Tm [(five)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.48100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.98100281 27.3220005 Tm [(WD)1(-repeat)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.77900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.27900696 27.3220005 Tm [(spa)1(n)-1(ning)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.95700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.45700073 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.13101196 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.63101196 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.47299194 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.80799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.30799866 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.58499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.08499908 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.60600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.10600281 42.92200089 Tm [(SOCS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.84999847 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.34999847 42.92200089 Tm [(bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.3809967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.8809967 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.82200623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.32200623 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.32299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.82299805 42.92200089 Tm [(C-t)1(e)-1(r)1(min)-1(us.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.88499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.38499451 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.19200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.69200134 42.92200089 Tm [(SOCS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.43600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.93600464 42.92200089 Tm [(bo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.5619998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.06200027 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.2329998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7329998 58.52199936 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.57400131 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.07400131 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.21500015 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.71500015 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.69000244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.19000244 58.52199936 Tm [(brid)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.38999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.88999939 58.52199936 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.96200562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.46200562 58.52199936 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.41900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.91900635 58.52199936 Tm [(subst)1(rat)1(e)-1(-)1(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.80599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.30599976 58.52199936 Tm [(do)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.08200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58200073 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.85900116 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.35900116 74.12200165 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.58499908 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.08499908 74.12200165 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.76599884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.26599884 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.57299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.07299805 74.12200165 Tm [(ligases.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.19900513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.69900513 74.12200165 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.04899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.54899597 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.47099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.97099304 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.54098511 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.34199905 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.84199905 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.78199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28199768 89.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.44200134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.94200134 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.28900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.78900146 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.29600525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.79600525 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.48599243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.98599243 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.26400757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.76400757 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.22000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.72000122 89.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.40200806 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 0.75 m 131.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 17.10000038 m 131.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 33.45000076 m 131.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 49.80000305 m 131.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 66.15000153 m 131.75 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 82.5 m 131.75 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 98.84999847 m 131.75 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 115.19999695 m 131.75 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>