%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 73.96600342 23.67700005 Tm 0 g [(WRAP53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.63000488 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.63000488 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 341.33401489 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WRA)1(P53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.18599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.43599701 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.43600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WRA)1(P53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.18599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.55999756 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.76199341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.13600159 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.49000549 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.96400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.17500305 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.72200012 12.82499981 Tm [(con)-1(taini)-1(ng,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.17700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.55099487 12.82499981 Tm [(anti)-1(sense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.20300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.57699585 12.82499981 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.6309967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.00500488 12.82499981 Tm [(TP53;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.99899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.3730011 12.82499981 Tm [(DKCB3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.72900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.10299683 12.82499981 Tm [(TC)-1(A)1(B1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.73699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.11099243 12.82499981 Tm [(WDR79)] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.25698853 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(WRA)1(P53)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 289.75500488 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 154.07499695 16.35000038 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(containing,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.65299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.15299988 11.72200012 Tm [(antisense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.51199341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.01199341 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.08700562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.58700562 11.72200012 Tm [(TP53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.80799866 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 154.07499695 16.35000038 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DK)1(CB)-1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.68000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.18000031 11.72200012 Tm [(TCAB1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.78399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.28399658 11.72200012 Tm [(WD)1(R7)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.72899628 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 154.07499695 16.35000038 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(U)1(R4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.13199997 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 154.07499695 16.35000038 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(02)-1(33)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 154.07499695 31.95000076 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.94799995 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 154.07499695 16.35000038 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 154.07499695 16.35000038 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 153.32499695 0.75 l 153.32499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 154.32499695 -0.25 l 154.32499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.07499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 154.07499695 94.34999847 l h f* Q q 1 0 0 1 153.69999695 0 cm -0.625 -0.25 m 273.4750061 -0.25 l 273.4750061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.71600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21600342 11.72200012 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.92399597 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.61300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.11300659 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.95500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.45500183 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.45599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.95599365 11.72200012 Tm [(telomer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.24699974 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74699974 27.3220005 Tm [(ho)1(l)-1(o)1(e)-1(nzyme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.50800323 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.00800323 27.3220005 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.65399933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.15399933 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.6289978 27.3220005 Tm [(ribo)1(n)-1(ucle)-1(o)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.06500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.56500244 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.04400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.54400635 27.3220005 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(quired)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.99799919 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.4980011 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.77600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.27600098 42.92200089 Tm [(telomere)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.93499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.43499756 42.92200089 Tm [(synthesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.80499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.30499268 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.06700134 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.37399292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.87399292 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.43499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93499756 42.92200089 Tm [(en)-1(r)1(i)-1(ched)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.33700562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.83700562 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.77801514 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Cajal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.7689991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.2689991 58.52199936 Tm [(bo)1(die)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.33000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.83000183 58.52199936 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.34799957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.84799957 58.52199936 Tm [(sites)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.03500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.53500366 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.3769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.8769989 58.52199936 Tm [(RNP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.57600403 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.07600403 58.52199936 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.63200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.13200378 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.35400391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.85400391 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.37199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.87199402 58.52199936 Tm [(imp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ort)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.38500023 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.88500023 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.1629982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.6629982 74.12200165 Tm [(telomerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.46199799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.96199799 74.12200165 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.8690033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3690033 74.12200165 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.36799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.86799622 74.12200165 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.71200562 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.21200562 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.60800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.10800171 74.12200165 Tm [(dyske)-1(r)1(i)-1(n,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.34500122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.84500122 74.12200165 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ERT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.9829998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.4829998 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.75999832 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.25999832 89.72200012 Tm [(TERC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.43000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93000031 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08899689 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.58899689 89.72200012 Tm [(components)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.44400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.94400024 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.78599548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.28599548 89.72200012 Tm [(active)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.352005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.852005 89.72200012 Tm [(telomerase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.81799316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.31799316 89.72200012 Tm [(an)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 0.75 m 153.69999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 17.10000038 m 153.69999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 33.45000076 m 153.69999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 49.80000305 m 153.69999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 66.15000153 m 153.69999695 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 98.1000061 m 153.69999695 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 114.45000458 m 153.69999695 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.69999695 130.80000305 m 153.69999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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