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EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WIF1)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 85.13300323 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.38300323 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.38299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WIF1)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 85.13300323 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 87.50700378 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 120.70899963 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 123.08300018 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 183.06300354 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 185.43699646 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 219.91099548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WN)1(T)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 84.23600006 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 86.61000061 12.82499981 Tm [(in)-1(hi)-1(bi)-1(tory)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 127.85600281 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 130.22999573 12.82499981 Tm [(factor)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 155.6190033 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 157.99299622 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 166.12399292 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 168.4980011 12.82499981 Tm [(WIF-1)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 193.84599304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 49 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 50 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(WIF1)] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAABB 9 Tf 1 0 0 -1 276.85198975 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 74 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 77 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ful)-1(l)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 15.11699963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 19.61700058 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 45.84400177 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 176.0249939 16.35000038 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WNT)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 21.63400078 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 26.13400078 11.72200012 Tm [(inhibito)1(ry)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 67.42900085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 71.92900085 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 97.04799652 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 101.54799652 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 106.8259964 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 176.0249939 16.35000038 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WIF-)1(1)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 25.75600052 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 176.0249939 16.35000038 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y5W5)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 37.75799942 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 101 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 176.0249939 16.35000038 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(18)-1(03)-1(7)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 104 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 105 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 176.0249939 31.95000076 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(-P)1(AGE)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 27.37400055 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 126 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 176.0249939 16.35000038 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 132 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 176.0249939 16.35000038 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 133 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 175.2749939 0.75 l 175.2749939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 176.2749939 -0.25 l 176.2749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 145 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 146 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.0249939 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 176.0249939 94.34999847 l h f* Q q 1 0 0 1 175.6499939 0 cm -0.625 -0.25 m 251.5249939 -0.25 l 251.5249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 147 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 199.01199341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 203.51199341 11.72200012 Tm [(to)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 212.58700562 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 217.08700562 11.72200012 Tm [(inhibi)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 3.35299993 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 7.85300016 27.3220005 Tm [(WNT)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 29.48699951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 33.98699951 27.3220005 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 71.62599945 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 76.12599945 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 101.22299957 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 105.72299957 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 119.24099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 123.74099731 27.3220005 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 175.93499756 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 180.43499756 27.3220005 Tm [(signaling)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 219.36599731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 223.86599731 27.3220005 Tm [(mol)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ec)-1(ule)-1(s)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 26.83300018 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 31.33300018 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 48.55500031 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 53.05500031 42.92200089 Tm [(play)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 70.93599701 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 75.43599701 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 80.41100311 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 84.91100311 42.92200089 Tm [(role)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 101.57099915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 106.07099915 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 114.01200104 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 118.51200104 42.92200089 Tm [(embryonic)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 164.17599487 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 168.67599487 42.92200089 Tm [(development.)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 227.83999634 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 232.33999634 42.92200089 Tm [(Th)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 6.56099987 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 11.06099987 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 42.36800003 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 46.86800003 58.52199936 Tm [(contains)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 83.08300018 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 87.58300018 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 92.55799866 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 97.05799866 58.52199936 Tm [(WNT)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 118.69200134 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 123.19200134 58.52199936 Tm [(inhibito)1(ry)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 164.48699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 168.98699951 58.52199936 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 194.10600281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 198.60600281 58.52199936 Tm [(\(WIF\))] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 221.20300293 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 225.70300293 58.52199936 Tm [(do)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(main)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 21.34900093 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 25.84900093 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 42.12599945 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 46.62599945 74.12200165 Tm [(five)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 61.97200012 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 66.47200012 74.12200165 Tm [(epidermal)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 109.8239975 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 114.3239975 74.12200165 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 145.24000549 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 149.74000549 74.12200165 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 174.85899353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 179.35899353 74.12200165 Tm [(\(EG)1(F)-1(\)-)1(li)-1(ke)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 220.48300171 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 224.98300171 74.12200165 Tm [(do)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mains,)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 27.68099976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 32.18099976 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 48.45800018 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 52.95800018 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 59.51900101 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 64.01899719 89.72200012 Tm [(th)1(ought)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 98.83200073 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 103.33200073 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 112.40699768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 116.90699768 89.72200012 Tm [(be)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 127.76100159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 132.26100159 89.72200012 Tm [(involved)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 168.63000488 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 173.13000488 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 181.07099915 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 185.57099915 89.72200012 Tm [(mesoderm)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 231.73100281 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 236.23100281 89.72200012 Tm [(s)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 0.75 m 175.6499939 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 17.10000038 m 175.6499939 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 33.45000076 m 175.6499939 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 49.80000305 m 175.6499939 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 66.15000153 m 175.6499939 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 98.1000061 m 175.6499939 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 114.45000458 m 175.6499939 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6499939 130.80000305 m 175.6499939 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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