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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.55200195 23.67700005 Tm 0 g [(WD)-1(R8)1(3)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 148.04400635 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 159.04400635 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.74798584 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WDR83)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 100.39600372 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.39599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WDR83)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 97.51999664 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 130.72200012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 133.09599304 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 193.07600403 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 195.44999695 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 229.92399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 81.17500305 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 109.34799957 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 111.72200012 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 144.1190033 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 146.49299622 12.82499981 Tm [(83;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 159.94599915 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 162.32000732 12.82499981 Tm [(MORG1)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 195.89599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 49 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 50 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(107-3)1(15)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(WDR83)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 343.35998535 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 81 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 86 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 85.56600189 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 90.06600189 11.72200012 Tm [(83)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 100.62200165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MORG)1(1)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 33.97399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(RX9)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 35.2179985 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 105 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(05)-1(87)-1(0)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 109 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 126 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 129 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 134 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 135 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 136 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 148 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 149 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 112.42500305 109.94999695 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(WD)1(-40)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 200.74000549 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 205.24000549 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 236.54699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 241.04699707 11.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 269.29501343 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 273.79501343 11.72200012 Tm [(The)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 289.60198975 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 294.10198975 11.72200012 Tm [(pr)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 22.12199974 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 26.62199974 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 33.18299866 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 37.68299866 27.3220005 Tm [(pro)1(posed)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 79.08799744 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 83.58799744 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 92.66300201 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 97.16300201 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 132.90400696 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 137.40400696 27.3220005 Tm [(as)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 146.54499817 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 151.04499817 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 156.02000427 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 160.52000427 27.3220005 Tm [(molec)-1(ular)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 203.04100037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 207.54100037 27.3220005 Tm [(scaff)1(old)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 241.30900574 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 245.80900574 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 258.08700562 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 262.58700562 27.3220005 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 293.55099487 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 298.05099487 27.3220005 Tm [(m)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ultimeric)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 37.57300186 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 42.07300186 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 73.37999725 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 77.87999725 42.92200089 Tm [(complexe)-1(s)1(.)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 125.79799652 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 130.29800415 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 146.10499573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 150.60499573 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 181.91200256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 186.41200256 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(s)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 229.94900513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 234.44900513 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 252.84500122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 257.34500122 42.92200089 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 287.2539978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 291.7539978 42.92200089 Tm [(co)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mpo)1(n)-1(ents)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 43.61999893 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 48.11999893 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 56.9620018 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 61.4620018 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 75.46299744 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 79.96299744 58.52199936 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 132.15699768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 136.65699768 58.52199936 Tm [(signal-)1(re)-1(g)1(ul)-1(a)1(ted)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 207.21600342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 211.71600342 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 238.80400085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 243.30400085 58.52199936 Tm [(\(ERK)1(\))] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 265.85198975 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 270.35198975 58.52199936 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(,)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 2.16700006 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 6.66699982 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 22.94400024 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 27.44400024 74.12200165 Tm [(pro)1(motes)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 69.1309967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 73.6309967 74.12200165 Tm [(ERK)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 90.16799927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 94.66799927 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 125.13999939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 129.63999939 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 137.58099365 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 142.08099365 74.12200165 Tm [(response)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 181.07800293 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 185.57800293 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 194.65299988 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 199.15299988 74.12200165 Tm [(serum)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 225.84100342 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 230.34100342 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 239.49899292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 243.99899292 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 267.1579895 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 271.6579895 74.12200165 Tm [(signals.)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 303.22399902 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 15.80700016 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 20.30699921 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 51.61399841 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 56.11399841 89.72200012 Tm [(also)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 73.3710022 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 77.8710022 89.72200012 Tm [(interacts)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 114.71499634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 119.21499634 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 137.61099243 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 142.11099243 89.72200012 Tm [(egl)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 155.3690033 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 159.8690033 89.72200012 Tm [(nin)-1(e)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 178.46200562 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 182.96200562 89.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 222.2539978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 226.7539978 89.72200012 Tm [(3)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 232.03199768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 236.53199768 89.72200012 Tm [(\(EG)1(L)-1(N3,)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 270.55899048 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 275.05899048 89.72200012 Tm [(also)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 292.31600952 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 296.81600952 89.72200012 Tm [(k)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nown)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 23.91900063 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 28.41900063 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 37.56000137 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 42.06000137 105.3219986 Tm [(PHD3\))] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 69.66600037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 74.16600037 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 90.44300079 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 94.94300079 105.3219986 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 134.78399658 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 139.28399658 105.3219986 Tm [(expression)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 185.23800659 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 189.73800659 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 198.58000183 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 203.08000183 105.3219986 Tm [(hypo)1(xia-inducible)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 280.08099365 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 284.58099365 105.3219986 Tm [(fa)1(c)-1(t)1(o)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 0.75 m 112.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 17.10000038 m 112.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 33.45000076 m 112.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 49.80000305 m 112.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 66.15000153 m 112.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 82.5 m 112.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 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