%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.55200195 23.67700005 Tm 0 g [(WD)-1(R4)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.04400635 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 159.04400635 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.74798584 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WDR41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 100.39600372 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.39599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WDR41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.51999664 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.72200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.09599304 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07600403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.44999695 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.92399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.17500305 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.72200012 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1190033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.49299622 12.82499981 Tm [(41;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.94599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.32000732 12.82499981 Tm [(MST)-1(P)1(048)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.62800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(WDR41)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 285.43499756 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 179.82499695 16.35000038 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56600189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.06600189 11.72200012 Tm [(41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.62200165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 179.82499695 16.35000038 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MSTP0)-1(48)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.48699951 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 179.82499695 16.35000038 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(A)1(D4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.03900146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 179.82499695 16.35000038 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(40)-1(24)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 179.82499695 31.95000076 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(S-PA)1(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.56800079 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 179.82499695 16.35000038 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 179.82499695 16.35000038 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 179.07499695 0.75 l 179.07499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 180.07499695 -0.25 l 180.07499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.82499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 179.82499695 94.34999847 l h f* Q q 1 0 0 1 179.44999695 0 cm -0.625 -0.25 m 247.7250061 -0.25 l 247.7250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)1(-repeat)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.79800034 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.29800034 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.81600189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.31600189 11.72200012 Tm [(mot)1(ifs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.50499725 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.00499725 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.22699738 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.72699738 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.24499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.74499512 11.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.43499756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.93499756 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.87600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.37600708 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.35099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.85099792 11.72200012 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.60400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.10400391 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.0929985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.5929985 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86999893 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37000275 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.38800049 27.3220005 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.92100525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.42100525 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.93299866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.43299866 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.40800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.90800476 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.98500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.48500061 27.3220005 Tm [(cor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.44799995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.94799995 42.92200089 Tm [(40)-1(-)1(6)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.95299911 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.45299911 42.92200089 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.52300262 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.02300262 42.92200089 Tm [(acids,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.99500275 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.49500275 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.59199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.09199524 42.92200089 Tm [(commonly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.6190033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.1190033 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.83000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.33000183 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.30499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.80499268 42.92200089 Tm [(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tia)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.92300034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.42300034 58.52199936 Tm [(pro)1(pell)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.51699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.01699829 58.52199936 Tm [(st)1(ruc)-1(ture.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.63999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.13999939 58.52199936 Tm [(Wh)1(il)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73599243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.23599243 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.70899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.20899963 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.43099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.93099976 58.52199936 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.97999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(WD)1(-repeat)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.79800034 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.29800034 74.12200165 Tm [(pa)1(rticipat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.29599762 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.79599762 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.73699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.23699951 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.21199799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.71200562 74.12200165 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.07600403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.57600403 74.12200165 Tm [(rang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.39599609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.89599609 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.73800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.23800659 74.12200165 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.5 74.12200165 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(unc)-1(t)1(i)-1(o)1(n)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.95299911 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.45299911 89.72200012 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.2179985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.71800232 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.23600006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.73600006 89.72200012 Tm [(gene)-1(r)1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.21600342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.71600342 89.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.08500671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.58500671 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.52600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.02600098 89.72200012 Tm [(regulat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.51600647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.01600647 89.72200012 Tm [(m)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 0.75 m 179.44999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 17.10000038 m 179.44999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 33.45000076 m 179.44999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 49.80000305 m 179.44999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 66.15000153 m 179.44999695 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 98.1000061 m 179.44999695 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 114.45000458 m 179.44999695 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.44999695 130.80000305 m 179.44999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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