%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.55200195 23.67700005 Tm 0 g [(WD)-1(R1)1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.04400635 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 159.04400635 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.74798584 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WDR19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 100.39600372 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.39599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WDR19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.51999664 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.72200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.09599304 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07600403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.44999695 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.92399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.26799774 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.44100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.90799713 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.30499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.77200317 12.82499981 Tm [(19;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.2250061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.69200134 12.82499981 Tm [(ATD5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.4750061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.94200134 12.82499981 Tm [(CED)-1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.25900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.72599792 12.82499981 Tm [(DY)-1(F-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.47299194 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.94000244 12.82499981 Tm [(ORF)-1(2)1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.8710022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.3380127 12.82499981 Tm [(Oseg)1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 335.69500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.1619873 12.82499981 Tm [(PW)1(DMP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 379.59899902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.06600952 12.82499981 Tm [(SRT)-1(D5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(IFT)-1(14)1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.36199951 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.73600006 30.49699783 Tm [(NP)1(HP13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.54799652 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(239-4)1(38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(WDR19)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 343.35998535 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56600189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.06600189 11.72200012 Tm [(19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.62200165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 151.0249939 31.95000076 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ATD5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.79199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.29199982 11.72200012 Tm [(CED)1(4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.56100082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.06100082 11.72200012 Tm [(DY)1(F-2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.46700287 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.96700287 11.72200012 Tm [(ORF26)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.68000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.17999268 11.72200012 Tm [(Oseg6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.98800659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.48800659 11.72200012 Tm [(PW)1(DMP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.47399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.97399902 11.72200012 Tm [(SRTD5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.50300598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.00300598 11.72200012 Tm [(IFT1)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.44399977 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.94400024 27.3220005 Tm [(NPHP13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79000092 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8NEZ3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.73600006 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(32)-1(57)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 151.0249939 31.95000076 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.94799995 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 129.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 145.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 151.0249939 63.15000153 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.29100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.79100037 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.01600647 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.32299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.82299805 11.72200012 Tm [(fa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.15299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.65299988 27.3220005 Tm [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.66699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.16699982 27.3220005 Tm [(repeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.05799866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.55799866 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.0759964 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.5759964 27.3220005 Tm [(minimally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.30599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.80599976 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.88299561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.38299561 27.3220005 Tm [(regions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.51100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.01100159 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.85299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.35299683 27.3220005 Tm [(ap)1(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(oxima)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.70399857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.20399857 42.92200089 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.75999832 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.25999832 42.92200089 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.33000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.83000183 42.92200089 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.63600159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.13600159 42.92200089 Tm [(typically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.43699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.93699646 42.92200089 Tm [(bra)1(c)-1(ke)-1(t)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.33200073 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.84399414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.34399414 42.92200089 Tm [(gly-h)1(i)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.2559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.7559967 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(tr)1(p-a)1(sp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.57699966 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.07699966 58.52199936 Tm [(\(GH-W)1(D\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.81600189 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.31600189 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.41300201 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.91300201 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.08399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.58399963 58.52199936 Tm [(fa)1(c)-1(ilitat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.16400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.66400146 58.52199936 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.36599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.86599731 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.70799255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.20799255 58.52199936 Tm [(hete)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 0.75 m 150.6499939 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 17.10000038 m 150.6499939 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 49.05000305 m 150.6499939 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 65.40000153 m 150.6499939 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 81.75 m 150.6499939 112.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 113.69999695 m 150.6499939 129.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 130.05000305 m 150.6499939 145.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 146.40000916 m 150.6499939 208.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 113.32499695 m 426.17498779 113.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 129.67500305 m 426.17498779 129.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 146.02500916 m 426.17498779 146.02500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17501831 m 426.92498779 209.17501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>