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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.1269989 23.67700005 Tm 0 g [(WD)-1(R5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.46899414 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.46899414 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.17300415 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(WDR5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8239975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.0739975 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.07400513 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WDR5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8239975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.19799805 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.40000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.77400208 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.7539978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.12800598 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.602005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.17500305 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.72200012 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1190033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.49299622 12.82499981 Tm [(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.62399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.9980011 12.82499981 Tm [(SWD3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.75500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.1289978 12.82499981 Tm [(BIG-3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.45599365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.83000183 12.82499981 Tm [(CF)-1(A)1(P89)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.39599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(WDR5)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 280.87298584 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 159.375 16.35000038 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56600189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.06600189 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.34400177 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 159.375 16.35000038 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SWD)1(3)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.65200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.15200043 11.72200012 Tm [(BIG-3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.97499847 11.72200012 Tm [(CFAP89)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.17099762 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 159.375 16.35000038 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P61)-1(96)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 159.375 16.35000038 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(63)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 159.375 31.95000076 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 159.375 16.35000038 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 159.375 16.35000038 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 158.625 0.75 l 158.625 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 159.625 -0.25 l 159.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.375 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 159.375 94.34999847 l h f* Q q 1 0 0 1 159 0 cm -0.625 -0.25 m 268.17498779 -0.25 l 268.17498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.29100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.79100037 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.01600647 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.32299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24799919 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.7480011 27.3220005 Tm [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.76200104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.26200104 27.3220005 Tm [(repeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.15299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.65299988 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.17099762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.67099762 27.3220005 Tm [(minimally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.40100098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90100098 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.97799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.47799683 27.3220005 Tm [(regions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.60600281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.10600281 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.94799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.44799805 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pp)1(roximat)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.63700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.13700104 42.92200089 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.69300079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.19300079 42.92200089 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.26300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.76300049 42.92200089 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.56900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.06900024 42.92200089 Tm [(typically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.36999512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.86999512 42.92200089 Tm [(bra)1(c)-1(ke)-1(t)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.76499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.26499939 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.7769928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2769928 42.92200089 Tm [(gly-h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.33799934 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.83799934 58.52199936 Tm [(tr)1(p-a)1(sp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.15800095 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.65799713 58.52199936 Tm [(\(GH-W)1(D\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.39700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.89700317 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.9940033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.4940033 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.66499329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.16499329 58.52199936 Tm [(fa)1(c)-1(ilitat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.74499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.24499512 58.52199936 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.94700623 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 74.12200165 Tm [(heterot)1(rime)-1(r)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.6760025 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.1760025 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.33399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.83399963 74.12200165 Tm [(multipro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.76300049 74.12200165 Tm [(complexe)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.68099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.18099976 74.12200165 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.97099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.47099304 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.31298828 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 89.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.0379982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.5379982 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.05599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.55599976 89.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.92500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.42500305 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.36599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.86599731 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.84100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.34100342 89.72200012 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.09399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.59399414 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.43600464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.93600464 89.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.69799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.19799805 89.72200012 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.49499512 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 0.75 m 159 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 17.10000038 m 159 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 33.45000076 m 159 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 49.80000305 m 159 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 66.15000153 m 159 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 98.1000061 m 159 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 114.45000458 m 159 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159 130.80000305 m 159 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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