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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.08899689 23.67700005 Tm 0 g [(VP)-1(S)1(41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.5059967 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.5059967 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.20999146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(VPS41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.09999847 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.1000061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VPS41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.22399902 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.4260025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.80000305 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.77999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.15400696 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.62800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VPS41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.22399902 12.82499981 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.3239975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.69799805 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.43899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.81300354 12.82499981 Tm [(HOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.55599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.92999268 12.82499981 Tm [(compl)-1(e)1(x)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.80299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.17700195 12.82499981 Tm [(HVPS)-1(4)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.37800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.7519989 12.82499981 Tm [(HVS)-1(P4)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.95300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.32699585 12.82499981 Tm [(hV)-1(ps41p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.58499146 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(VPS41)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 280.89498901 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 156.32499695 16.35000038 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VPS4)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.14299774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.64299774 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98500061 11.72200012 Tm [(HOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.98100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.48100281 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96000671 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 156.32499695 16.35000038 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HV)-1(PS41)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.47000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [(HV)-1(SP41)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.44000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.94000244 11.72200012 Tm [(hVps41p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.78600311 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 156.32499695 16.35000038 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P49)-1(75)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 156.32499695 16.35000038 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(44)-1(85)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 156.32499695 31.95000076 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 156.32499695 16.35000038 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 156.32499695 16.35000038 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 155.57499695 0.75 l 155.57499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 156.57499695 -0.25 l 156.57499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.32499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 156.32499695 94.34999847 l h f* Q q 1 0 0 1 155.94999695 0 cm -0.625 -0.25 m 271.2250061 -0.25 l 271.2250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ve)-1(sicle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.7689991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.26900101 11.72200012 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.15100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.65100098 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.95800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.45800018 11.72200012 Tm [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.83299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.33299255 11.72200012 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.38000488 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.88000488 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.40100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.90100098 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.86199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.36199951 11.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.52200317 11.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(segregat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.36500168 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.86499786 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.70700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.20700073 27.3220005 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.67399597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.17399597 27.3220005 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05700684 27.3220005 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.07299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.57299805 27.3220005 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.05099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.55099487 27.3220005 Tm [(org)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ne)-1(lles.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.88100052 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.38100052 42.92200089 Tm [(Gene)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.09400177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.59400177 42.92200089 Tm [(st)1(u)-1(d)1(ie)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.08300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.58300018 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.52400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.02400208 42.92200089 Tm [(ye)-1(a)1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.38800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.88800049 42.92200089 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.23500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.73500061 42.92200089 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.66600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.16600037 42.92200089 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.86399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.36399841 42.92200089 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.7789917 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 58.52199936 Tm [(vacuolar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.34199905 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.84199905 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.14900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.64900208 58.52199936 Tm [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.02400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.52400208 58.52199936 Tm [(\(VPS\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.32299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.82299805 58.52199936 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.00500488 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.37399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.87399292 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.81500244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.31500244 58.52199936 Tm [(vesic)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.3409996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.8409996 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.91600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.41600037 74.12200165 Tm [(vacuole)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.72899628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.22899628 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.49099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.99099731 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.50700378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.00700378 74.12200165 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.92399597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.42399597 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.42500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.92500305 74.12200165 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.96600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.46600342 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(olog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.48999977 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.99000168 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.83200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.33200073 89.72200012 Tm [(ye)-1(a)1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.69599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.19599915 89.72200012 Tm [(Vps41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.7519989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.2519989 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.55900574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.05900574 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.15600586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.65600586 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.21699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.71699524 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.97399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.47399902 89.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.55099487 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.05099487 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.99200439 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 0.75 m 155.94999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 17.10000038 m 155.94999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 33.45000076 m 155.94999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 49.80000305 m 155.94999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 66.15000153 m 155.94999695 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 98.1000061 m 155.94999695 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 114.45000458 m 155.94999695 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.94999695 130.80000305 m 155.94999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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