%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 125 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 -0.75 0 cm q -1 -1 m 448.29998779 -1 l 448.29998779 43.70000076 l -1 43.70000076 l h W n q 1 0 0 1 0.75 0.75 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [( )-4( )-4( )-4( )-4( )-4( )-4( )-4( )-4( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99 23.67700005 Tm [(V)-4(R)-4(K)-4(1)] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 148.852005 23.67700005 Tm [<0007>-4<0008>-4<0009>-4<000A>-4<000B>-4<000C>-4<000D>-4<000E>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 325.55599976 19.63899994 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 42.70000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<000F0010001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 30.76399994 Tm [(VRK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43599701 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 90.68599701 30.76399994 Tm [<000700080009000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.68600464 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 94.1780014 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<00140010001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VRK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.80999756 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.01200104 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.38600159 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.36599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.74000549 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.21400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 127.71700287 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00110013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(vacc)1(i)-1(ni)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.01699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.39099884 12.82499981 Tm [(re)1(l)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.9730072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.34700012 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.40699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.78100586 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.91200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.28599548 12.82499981 Tm [(PCH1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.98199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.35600281 12.82499981 Tm [(PCH1A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.31799316 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 161.2559967 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<00160017001800150013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 194.79499817 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001A0013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001B001C0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 228.33399963 m 416.75 228.33399963 l 416.75 259.53399658 l -1.45000005 259.53399658 l h f* Q q 1 0 0 1 0 228.33399963 cm /P <> BDC q 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAADA 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 259.53399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 287.47299194 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(197-3)1(96)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(VRK1)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 335.03601074 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0 G 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0 G 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0 G 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0 G 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 g -1.45000005 316.4119873 m 416.75 316.4119873 l 416.75 347.61199951 l -1.45000005 347.61199951 l h f* Q q 1 g -1.45000005 347.61199951 m 416.75 347.61199951 l 416.75 378.81201172 l -1.45000005 378.81201172 l h f* Q q 1 0 0 1 0 316.4119873 cm /P <> BDC BT /FAAADA 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAADA 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 378.81201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 406.75100708 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(vacc)-1(inia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0359993 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5359993 11.72200012 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.66500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.16500092 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.25299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.75299835 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03099823 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(PCH1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.93199921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.43199921 11.72200012 Tm [(PCH1)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.52999878 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q99)-1(98)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(BC1)-1(13)-1(51)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 50.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 135.67500305 94.34999847 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADD 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(vacc)-1(inia-)1(re)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.83500671 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.92300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.42300415 11.72200012 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(VRK\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.18099976 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.26300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.76300049 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.60500336 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.10500336 27.3220005 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.45899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.95899963 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.26600647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.76600647 27.3220005 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.18600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.68600464 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.94799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.44799805 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.96398926 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.46398926 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.0249939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(wid)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.52300072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.02299881 42.92200089 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.17700195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.67700195 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.61799622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.11799622 42.92200089 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.65899658 42.92200089 Tm [(tiss)1(u)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.55700684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.05700684 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.33399963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.83399963 42.92200089 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.51600647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.01600647 42.92200089 Tm [(inc)-1(reased)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.51699829 42.92200089 Tm [(express)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.10400009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.60400009 58.52199936 Tm [(actively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.82899857 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.32900238 58.52199936 Tm [(divid)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.05500031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.55500031 58.52199936 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.29699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.79699707 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.56399536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.06399536 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.20500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.70500183 58.52199936 Tm [(th)1(ose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.59399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.09399414 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.03500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.53500366 58.52199936 Tm [(test)1(i)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.24099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.74099731 58.52199936 Tm [(th)1(y)-1(mus,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.71099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(feta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.9489994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.4489994 74.12200165 Tm [(live)-1(r)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.67300034 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.17300034 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.44999695 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.94999695 74.12200165 Tm [(carci)-1(noma)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.79000092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.29000092 74.12200165 Tm [(Its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.45500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.95500183 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.26199341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.76199341 74.12200165 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.85400391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.35400391 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.42900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.92900085 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.92999268 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.42999268 74.12200165 Tm [(nuc)-1(leu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.94300079 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.44300079 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.125 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.625 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.13200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63200378 89.72200012 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.71299744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.21299744 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.28800201 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.78800201 89.72200012 Tm [(pro)1(mote)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.30900574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.80900574 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.80999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.30999756 89.72200012 Tm [(st)1(ability)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.85299683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.35299683 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.63000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.13000488 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.64801025 89.72200012 Tm [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 0.75 m 135.30000305 16.35000038 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 17.10000038 m 135.30000305 32.70000076 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 33.45000076 m 135.30000305 49.05000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 49.80000305 m 135.30000305 65.40000153 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 66.15000153 m 135.30000305 81.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 82.5 m 135.30000305 98.09999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 98.84999847 m 135.30000305 114.44999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 115.19999695 m 135.30000305 208.79998779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.79998779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 423.17498779 209.17498779 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>