%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.4240036 23.67700005 Tm 0 g [(VP)-1(S)1(33A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.17199707 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 160.17199707 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 336.87600708 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(VPS33A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.92500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 101.17500305 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 185.17500305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VPS33A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.92500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.2990036 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.50100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.875 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.85499573 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.22900391 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.70300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VPS33A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.92500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.2990036 12.82499981 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.16100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.53500366 12.82499981 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.00900269 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.75 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.12399292 12.82499981 Tm [(CORV)-1(ET)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.57699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.95100403 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.01400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.38800049 12.82499981 Tm [(HOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.1309967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.50500488 12.82499981 Tm [(compl)-1(e)1(x)-1(e)1(s;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.70901489 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.08300781 12.82499981 Tm [(MPSPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.55801392 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(VPS33A)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 286.10299683 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VPS3)-1(3A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.67499924 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.17499924 11.72200012 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.95299911 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.45299911 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.25299835 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.09500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.59500122 11.72200012 Tm [(CORVET)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.51899719 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.79600525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.29600525 11.72200012 Tm [(HOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.29200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.79200745 11.72200012 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.54299927 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MPSPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.19499969 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(A)1(X1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.30599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(16)-1(61)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 135.67500305 109.94999695 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(tet)1(he)-1(r)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.76499939 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.07200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.57200623 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.34899902 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.32400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.82400513 11.72200012 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.602005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.102005 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.40200806 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.90200806 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.74398804 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 27.3220005 Tm [(ho)1(motypic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.69200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.19200134 27.3220005 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.68699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.18699646 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.46399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.96399689 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.27099609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.77099609 27.3220005 Tm [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.14599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.64599609 27.3220005 Tm [(\(HOPS\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.65400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.15400696 27.3220005 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.79998779 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.29998779 27.3220005 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(HOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.60200119 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.10200119 42.92200089 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.58100128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.08100128 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.35800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.85800171 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.83300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.33300018 42.92200089 Tm [(sec)-1(o)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.14300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64300537 42.92200089 Tm [(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.46400452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.96400452 42.92200089 Tm [(teth)1(e)-1(r)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.55900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05900574 42.92200089 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.53799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(calle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.14100075 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.64100075 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.64199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.14199829 58.52199936 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.35700226 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.85700226 58.52199936 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.87799835 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.37799835 58.52199936 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.15599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.65599823 58.52199936 Tm [(vacuole)-1(/endoso)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.03999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.53999329 58.52199936 Tm [(teth)1(e)-1(r)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.13499451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.63499451 58.52199936 Tm [(\(CORVET\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.0710144 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.64599991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.14599991 74.12200165 Tm [(perfo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.14800262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.64800262 74.12200165 Tm [(diverse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.33899689 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.83899689 74.12200165 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.7460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.2460022 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.18699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.68699646 74.12200165 Tm [(en)-1(d)1(ocy)-1(t)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.89599609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.39599609 74.12200165 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.2460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.7460022 74.12200165 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(embrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.35100174 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.85100174 89.72200012 Tm [(teth)1(e)-1(r)1(i)-1(ng)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.61199951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.11199951 89.72200012 Tm [(Rab)1(GTPase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.31599426 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.81599426 89.72200012 Tm [(interaction,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.32299805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.82299805 89.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.772995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.272995 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.54998779 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.04998779 89.72200012 Tm [(pro)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(fread)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.09199905 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.59199905 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.43399811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.93399811 105.3219986 Tm [(synapt)1(ic)-1(-s)1(olu)-1(b)1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.36499786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.86500549 105.3219986 Tm [(N-eth)1(y)-1(lma)1(l)-1(eimide-sensitive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.08200073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.58200073 105.3219986 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.70098877 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 0.75 m 135.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 17.10000038 m 135.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 33.45000076 m 135.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 49.80000305 m 135.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 66.15000153 m 135.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 82.5 m 135.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 98.84999847 m 135.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 115.19999695 m 135.30000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>