%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.97699738 23.67700005 Tm 0 g [(VNN2)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.6190033 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.32299805 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(VNN)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.83499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 93.08499908 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.08500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VNN)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.83499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.20899963 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.41100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.78500366 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.76499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.13900757 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.61300659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(vani)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.21499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.58899689 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.72000122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.09400177 12.82499981 Tm [(FO)-1(A)1(P-4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.71600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.08999634 12.82499981 Tm [(GP)1(I-)-1(8)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.64199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(294-4)1(93)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(VNN)1(2)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 337.09298706 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(vanin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.18600082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.68600082 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9640007 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(FOAP-)1(4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.29199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.79199982 11.72200012 Tm [(GP)1(I-80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.08599854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O95)-1(49)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(26)-1(14)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 143.92500305 109.94999695 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.85299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.35299683 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.91400146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.41400146 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.38899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.88899994 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.15299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.65299988 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.49499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.99499512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.9960022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.4960022 11.72200012 Tm [(Vanin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.04400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.54400635 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.62600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.12600708 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.96800232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.46800232 11.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.93500137 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.43500137 27.3220005 Tm [(sha)1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.66000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.16000366 27.3220005 Tm [(extensive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.22499847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.72499847 27.3220005 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.57200623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.07200623 27.3220005 Tm [(similarit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.77900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.27900696 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.67500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.17500305 27.3220005 Tm [(eac)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.31100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.81100464 27.3220005 Tm [(ot)1(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.60300016 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.10299969 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.37999916 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.87999916 42.92200089 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.13700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.63700104 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.03299713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.53299713 42.92200089 Tm [(biot)1(ini)-1(d)1(ase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.25700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.75700378 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.56399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.06399536 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.14599609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.64599609 42.92200089 Tm [(inc)-1(ludes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.07000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.57000732 42.92200089 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.11499023 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.61499023 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 58.52199936 Tm [(membrane-as)1(soc)-1(ia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.60800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.10800171 58.52199936 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.74699402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.24699402 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.22200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.72200012 58.52199936 Tm [(few)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.55499268 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.39700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.89700317 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.9940033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.4940033 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.84100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.34100342 58.52199936 Tm [(bee)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 74.12200165 Tm [(repor)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.7120018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.2120018 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.28699875 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.78700256 74.12200165 Tm [(pa)1(rticipat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.78500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.28500366 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.22599792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.72599792 74.12200165 Tm [(hemat)1(opoietic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.08900452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.58900452 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.99899292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.49899292 74.12200165 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.17599487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(No)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.03899956 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.53899956 89.72200012 Tm [(biot)1(ini)-1(d)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.09700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.59700012 89.72200012 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.06900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.56900024 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.25099945 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.75099945 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.25799561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.75799561 89.72200012 Tm [(demonst)1(rated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.46800232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.96800232 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.2460022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.7460022 89.72200012 Tm [(any)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.02999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.52999878 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.37200928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.87200928 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 105.3219986 Tm [(vanin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.33399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.83399963 105.3219986 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.47299957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.97299957 105.3219986 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.88200378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.38200378 105.3219986 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.14700317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.64700317 105.3219986 Tm [(po)1(sse)-1(s)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.88699341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.38699341 105.3219986 Tm [(pa)1(n)-1(t)1(e)-1(t)1(hein)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.30400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.80400085 105.3219986 Tm [(acti)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 0.75 m 143.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 17.10000038 m 143.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 33.45000076 m 143.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 49.80000305 m 143.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 66.15000153 m 143.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 82.5 m 143.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 98.84999847 m 143.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 115.19999695 m 143.55000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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