%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 109 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 149.46800232 23.67700005 Tm 0 g [(VEGFA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.65600586 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 221.65600586 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 265.83200073 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(VE)-1(GFA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.85800171 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 117.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.10800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A0006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VE)-1(GFA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.98200226 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00100009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 240.09500122 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 47.37799835 l -0.75 47.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Synth)-1(e)1(ti)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.04399872 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.12599945 12.04500008 Tm [(pepti)-1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.34799957 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.43000031 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.21700287 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.2990036 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.14199829 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.45300293 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.53500366 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.92700195 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.00900269 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.69000244 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.77200317 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.59199524 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.67399597 12.04500008 Tm [(130-1)1(43)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.79899597 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.8809967 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92199707 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.0039978 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.43499756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.51699829 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.01000977 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.0920105 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.77801514 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.85998535 12.04500008 Tm [(vascul)-1(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 370.8039856 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.88598633 12.04500008 Tm [(endo)-1(theli)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29598999 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 29.98399925 Tm [(gr)1(o)-1(wt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.29700089 29.98399925 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.33200073 29.98399925 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.09400177 29.98399925 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.12900162 29.98399925 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.3370018 29.98399925 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 46.37799835 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 46.37799835 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 46.62799835 m 426.3500061 46.62799835 l S Q Q q 1 0 0 1 0 286.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 314.9119873 m 416.75 314.9119873 l 416.75 346.11199951 l -1.45000005 346.11199951 l h f* Q q 1 0 0 1 0 314.9119873 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 346.11199951 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 374.05099487 cm q /GS2 gs 1 g 0.375 0.75 m 126.67500305 0.75 l 126.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 127.67500305 -0.25 l 127.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 45.78699875 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 127.42500305 16.35000038 l h f* Q q 1 0 0 1 127.05000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(vascular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.72999954 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.22999954 11.72200012 Tm [(en)-1(d)1(oth)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.02200317 11.72200012 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.93800354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.43800354 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.55700684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.05700684 11.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.38999939 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 126.67500305 0.75 l 126.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 127.67500305 -0.25 l 127.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 127.42500305 16.35000038 l h f* Q q 1 0 0 1 127.05000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VPF,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.54100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.04100037 11.72200012 Tm [(VEGF,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.7159996 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.2159996 11.72200012 Tm [(MVCD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.25 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 126.67500305 0.75 l 126.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 127.67500305 -0.25 l 127.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 44.07699966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 127.42500305 16.35000038 l h f* Q q 1 0 0 1 127.05000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P15)-1(69)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 126.67500305 0.75 l 126.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 127.67500305 -0.25 l 127.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 72.29399872 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 127.42500305 16.35000038 l h f* Q q 1 0 0 1 127.05000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NP_00)-1(10)-1(20)-1(537)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 126.67500305 0.75 l 126.67500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 127.67500305 -0.25 l 127.67500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.42500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 127.42500305 172.3500061 l h f* Q q 1 0 0 1 127.05000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(PDG)1(F/)-1(VEG)1(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.11099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.61099243 11.72200012 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.5269928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.0269928 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.64599609 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.72799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 27.3220005 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.69400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.19400024 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.16899872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.66899872 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.97599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47599792 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.19799805 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.75900269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.25900269 27.3220005 Tm [(of)1(ten)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.10600281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.60600281 27.3220005 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.29600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.79600525 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.93699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.43699646 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.41200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.91200256 27.3220005 Tm [(disulfid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.54901123 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.04901123 27.3220005 Tm [(link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.14801025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ho)1(modimer.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.7120018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.2120018 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.47399902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.97399902 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.28099823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.78099823 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.34200287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84200287 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.81700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.31700134 42.92200089 Tm [(glyc)-1(o)1(syl)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.98300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.48300171 42.92200089 Tm [(mito)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.79499817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.29499817 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.51699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.01699829 42.92200089 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.52799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.02799988 58.52199936 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.03499985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.53499985 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.8030014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3030014 58.52199936 Tm [(en)-1(d)1(oth)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.59500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.09500122 58.52199936 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.67099762 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.17100525 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.44799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.94799805 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.63000488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.13000488 58.52199936 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.09399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.59399414 58.52199936 Tm [(effec)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.2460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.7460022 58.52199936 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.5960083 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.71699905 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.21699905 74.12200165 Tm [(inc)-1(reased)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.21800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.71800232 74.12200165 Tm [(vascular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.44799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.94799805 74.12200165 Tm [(permeability,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.96899414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.46899414 74.12200165 Tm [(induc)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.92399597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.42399597 74.12200165 Tm [(angio)1(gen)-1(esi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 89.72200012 Tm [(vasculogene)-1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.11599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.61599731 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.89299774 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.39299774 89.72200012 Tm [(en)-1(d)1(oth)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.68499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.18499756 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.59500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.09500122 89.72200012 Tm [(gr)1(owt)1(h,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.17700195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.67700195 89.72200012 Tm [(pro)1(moting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.78900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.28900146 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.69900513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.19900513 89.72200012 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(igra)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.74499893 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.24499893 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.52199936 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.02199936 105.3219986 Tm [(inhibiting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.09300232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.59300232 105.3219986 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.7539978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.2539978 105.3219986 Tm [(Elevat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.6190033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.1190033 105.3219986 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.01199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.51199341 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.35400391 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.85400391 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.30999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.80999756 105.3219986 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 120.92199707 Tm [(link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.20600128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.70600128 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.78099823 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.28099823 120.92199707 Tm [(POEMS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.05799866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.55799866 120.92199707 Tm [(syndrome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.65499878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.15499878 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.41200256 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.91200256 120.92199707 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.73100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.23100281 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.37199402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.87199402 120.92199707 Tm [(Crow)1(-Fuk)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.52398682 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.02398682 120.92199707 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(yn)-1(d)1(rome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.93099976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.43099976 136.52200317 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.27999878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.77999878 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.72100067 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.22100067 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.67700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.17700195 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.69299316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.19299316 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.53999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.03999329 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.54699707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.04699707 136.52200317 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.17399597 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.67399597 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.07000732 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.57000732 136.52200317 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(oliferat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.72800064 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.22800064 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.50500107 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.00499725 152.12199402 Tm [(nonpro)1(l)-1(if)1(e)-1(ra)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73100281 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.23100281 152.12199402 Tm [(dia)1(be)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.4730072 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.9730072 152.12199402 Tm [(retinopa)1(thy.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.07899475 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.57899475 152.12199402 Tm [(Alt)1(e)-1(rna)1(tivel)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 167.72200012 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.34500122 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.84500122 167.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.76699829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.26699829 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.00299835 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.50300598 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.84500122 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.34500122 167.72200012 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.28399658 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.78399658 167.72200012 Tm [(freely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.71200562 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.21200562 167.72200012 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.75698853 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.25698853 167.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.41500854 167.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 237.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.05000305 0.75 m 127.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.05000305 17.10000038 m 127.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.05000305 33.45000076 m 127.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.05000305 49.80000305 m 127.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.05000305 66.15000153 m 127.05000305 237.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 237.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 238.125 m 423.17498779 238.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>