%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.3239975 23.67700005 Tm 0 g [(VASP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.27099609 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 322.9750061 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(VASP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.28199768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.53199768 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.53199768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VASP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.28199768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65599823 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.23200226 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.21200562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.58599854 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.05999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(vasod)-1(ilato)-1(r)1(-)-1(stimul)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.34599304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.72000122 12.82499981 Tm [(ph)-1(osp)-1(hop)-1(r)1(o)-1(te)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.34899902 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(181-3)1(80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(VASP)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 334.90499878 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(vaso)1(dilat)1(or-st)1(imul)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.49199677 11.72200012 Tm [(ph)1(osph)1(opro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.98699951 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P50)-1(55)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(38)-1(22)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 137.92500305 125.55000305 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 285.875 -0.25 l 285.875 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Vasod)1(il)-1(a)1(tor)1(-st)1(i)-1(mulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.35399628 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.85399628 11.72200012 Tm [(ph)1(osph)1(opro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.34899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.84899902 11.72200012 Tm [(\(VASP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.97999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.47999573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.04100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.54100037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.01600647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.27999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.77999878 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.62100029 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.12100029 27.3220005 Tm [(Ena-)1(V)-1(A)1(SP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.60299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.10299683 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.41000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.91000366 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.15800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.65800476 27.3220005 Tm [(Ena-)1(V)-1(A)1(SP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.13999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.63999939 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.72200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.22200012 27.3220005 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.65200806 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15200806 27.3220005 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ntain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.81399918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.31399918 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.83499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.33499908 42.92200089 Tm [(EHV)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.60800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.10800171 42.92200089 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.95800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.45800018 42.92200089 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.28500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.78500366 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.00700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.50700378 42.92200089 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.1190033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.6190033 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.09199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.59199524 42.92200089 Tm [(contai)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.24399948 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.74399948 58.52199936 Tm [(E/DFPPP)1(PXD/E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65399933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.15399933 58.52199936 Tm [(mot)1(ifs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.34300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.84300232 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.11999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.61999512 58.52199936 Tm [(ta)1(rgets)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.76600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.26600647 58.52199936 Tm [(Ena-)1(V)-1(A)1(SP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.7480011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.2480011 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.7210083 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.2210083 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.29598999 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(fo)1(c)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.72500038 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.22500038 74.12200165 Tm [(ad)1(hesions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.76599884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.26599884 74.12200165 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.45700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.95700073 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.95800018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.45800018 74.12200165 Tm [(mid-)1(re)-1(g)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.89900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.39900208 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.24099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.74099731 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.74200439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.24200439 74.12200165 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.71499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.21499634 74.12200165 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.29699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.79699707 74.12200165 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mbers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.88999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.38999939 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.73699951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.23699951 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.2120018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.71199799 89.72200012 Tm [(pro)1(lin)-1(e-rich)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.83999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.33999634 89.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.16700745 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.66700745 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.88900757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.38900757 89.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.00100708 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.50100708 89.72200012 Tm [(SH)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.93400574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.43400574 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.71099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.21099854 89.72200012 Tm [(WW)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.52700806 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(do)1(main-c)-1(o)1(ntaining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.46800232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.96800232 105.3219986 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.60700226 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.10699463 105.3219986 Tm [(Their)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.7460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.2460022 105.3219986 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.80000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.30000305 105.3219986 Tm [(EVH)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.57299805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.07299805 105.3219986 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.8999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.29199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.79199982 120.92199707 Tm [(tetr)1(amerizat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.80200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.30200195 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.57899475 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.07899475 120.92199707 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.69099426 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.19099426 120.92199707 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.05499268 120.92199707 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.7480011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.2480011 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.5249939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.0249939 120.92199707 Tm [(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.80599976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.30599976 120.92199707 Tm [(actin.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2539978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.7539978 120.92199707 Tm [(VAS)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 0.75 m 137.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 17.10000038 m 137.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 33.45000076 m 137.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 49.80000305 m 137.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 66.15000153 m 137.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 82.5 m 137.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 98.84999847 m 137.55000305 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.0249939 m 423.17498779 224.0249939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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