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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.16200256 23.67700005 Tm 0 g [(US)1(P)-1(35)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.43299866 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.13699341 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(USP35)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.8789978 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.8789978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP35)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.00299835 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.20500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.57899475 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.55900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.93299866 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.40699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26400757 12.82499981 Tm [(35)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.90800476 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(819-1)1(018)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.54100037 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.57600403 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.61700439 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65200806 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.08300781 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.11801147 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.61099243 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.64599609 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.33200073 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.36700439 12.04500008 Tm [(USP35)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 344.04901123 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(35)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04800415 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9P2)-1(H5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.63499832 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(31)-1(48)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 129.67500305 94.34999847 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(USP35)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.97599983 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.47600174 11.72200012 Tm [(\(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.16300201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.66300201 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.62000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.12000275 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.47399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.97399902 11.72200012 Tm [(35)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.53599548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.03599548 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.59700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.09700012 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.07200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.57200623 11.72200012 Tm [(1,0)-1(17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.8500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.3500061 11.72200012 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.41999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.92001343 11.72200012 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.55999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.02899933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.52899933 27.3220005 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.96900177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.46900177 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.54399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.04399872 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.04499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.54499817 27.3220005 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.89900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.39900208 27.3220005 Tm [(C19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.9750061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.4750061 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.7230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.2230072 27.3220005 Tm [(Exp)1(re)-1(s)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.21899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.71899414 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.66000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pa)1(n)-1(creas,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.63199997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.13199997 42.92200089 Tm [(test)1(i)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.67199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.17199707 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.4489975 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.9489975 42.92200089 Tm [(ske)-1(leta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.34500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84500122 42.92200089 Tm [(musc)-1(le,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.17100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.67100525 42.92200089 Tm [(USP35)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.64700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.14700317 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.05400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.55400085 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.6289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.1289978 42.92200089 Tm [(cata)1(l)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ze)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.53199959 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.03199959 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.03300095 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.53300095 58.52199936 Tm [(conve)-1(rs)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.40899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.90899658 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.75099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.25099945 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.22599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.72599792 58.52199936 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.40699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.90699768 58.52199936 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.46099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.96099854 58.52199936 Tm [(th)1(ioe)-1(s)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.14100647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.64100647 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.91799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.41799927 58.52199936 Tm [(wa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.01199913 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51199913 74.12200165 Tm [(free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.2820015 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.7820015 74.12200165 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.46299744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.96299744 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.23999786 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.73999786 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.71499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.21499634 74.12200165 Tm [(th)1(iol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.78799438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.28799438 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.76300049 74.12200165 Tm [(reaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.80900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.30900574 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.53100586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.03100586 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.20199585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.70199585 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.58299255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.08300781 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.05801392 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.55801392 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.21798706 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 89.72200012 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.37200165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.87200165 89.72200012 Tm [(eve)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.87400055 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.37400055 89.72200012 Tm [(th)1(rough)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.89199829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.39199829 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.39300537 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.89300537 89.72200012 Tm [(ce)-1(ll.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.46899414 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 0.75 m 129.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 17.10000038 m 129.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 33.45000076 m 129.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 49.80000305 m 129.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 66.15000153 m 129.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 82.5 m 129.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 98.84999847 m 129.30000305 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 192.82499695 m 423.17498779 192.82499695 l S Q Q q 1 0 0 1 0 586.11199951 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm
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