%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.16200256 23.67700005 Tm 0 g [(US)1(P)-1(21)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.43299866 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.13699341 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(USP21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.8789978 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.8789978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.00299835 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.20500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.57899475 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.55900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.93299866 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.40699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26400757 12.82499981 Tm [(21;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.09100342 12.82499981 Tm [(USP16)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.52999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.90400696 12.82499981 Tm [(USP23)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.5329895 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(366-5)1(65)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(USP21)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 339.48800659 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04800415 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(USP16;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.1420002 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.64199829 11.72200012 Tm [(USP23)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.61800003 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UK80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.59999847 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(03)-1(13)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 152.17500305 31.95000076 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 152.17500305 94.34999847 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(C19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.85299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.35299683 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.70700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.20700073 11.72200012 Tm [(fa)1(mi)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(y,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.92999983 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.43000031 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.68700027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.18700027 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.00600052 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.5059967 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.64700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.14700317 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.22899628 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.72899628 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.00700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.50700378 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.34899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.84899902 27.3220005 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.52999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.02999878 27.3220005 Tm [(carbo)1(xy)-1(-)1(terminal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.28199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.78199768 27.3220005 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ydrola)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.65299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.15299988 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.95999908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.45999908 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.96700287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.46700287 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.77400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.27400208 42.92200089 Tm [(cl)-1(eaves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.25999451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.75999451 42.92200089 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.44099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.94099426 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.6519928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.1519928 42.92200089 Tm [(ubi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(quitinat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.18299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.68299866 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.15599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65599823 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.93399811 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.43399811 58.52199936 Tm [(rec)-1(ycl)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.86000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.36000061 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.30099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.80099487 58.52199936 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.26800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.76800537 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.07499695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.57499695 58.52199936 Tm [(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(gr)1(adat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.08200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.58200073 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.38899994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.88899994 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.39600372 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.89600372 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.20300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.70300293 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.26400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.76400757 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.02099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.52099609 74.12200165 Tm [(ab)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.74499512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.24499512 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.32000732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.82000732 74.12200165 Tm [(rele)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.11199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.61199951 74.12200165 Tm [(NE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(DD)1(8)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.15500069 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.65500069 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.62999916 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.13000107 89.72200012 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.50099945 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.00099945 89.72200012 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.47399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.97399902 89.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.68499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.18499756 89.72200012 Tm [(NEDD)1(8)-1(-)1(c)-1(o)1(n)-1(juga)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.01100159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.51100159 89.72200012 Tm [(pro)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 0.75 m 151.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 17.10000038 m 151.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 33.45000076 m 151.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 49.80000305 m 151.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 66.15000153 m 151.80000305 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 98.1000061 m 151.80000305 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 114.45000458 m 151.80000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 130.80000305 m 151.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 422.42498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 422.42498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 422.42498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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