%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.41200256 23.67700005 Tm 0 g [(US)1(P)-1(15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18299866 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.18299866 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.88699341 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(USP15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.8789978 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.8789978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.00299835 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.20500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.57899475 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.55900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.93299866 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.40699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26400757 12.82499981 Tm [(15;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.09100342 12.82499981 Tm [(UN)1(PH4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.70300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.07699585 12.82499981 Tm [(UN)1(PH-2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.09399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(USP15)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 281.56298828 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04800415 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UNP)1(H)-1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.94800186 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.44800186 11.72200012 Tm [(UNP)1(H)-1(-)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.1230011 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y4E8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.54800034 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(25)-1(12)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 146.17500305 109.94999695 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.95799255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.45799255 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.41499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.91499329 11.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.35400009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.85400009 27.3220005 Tm [(\(USP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.2859993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.7859993 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.86799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.36799622 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.20999908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.70999908 27.3220005 Tm [(deubiquitinat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.77900696 27.3220005 Tm [(en)-1(z)1(y)-1(mes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.49200439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.99200439 27.3220005 Tm [(USP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.41200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.91200256 27.3220005 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.54700089 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.04700089 42.92200089 Tm [(critic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.02299881 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.52299881 42.92200089 Tm [(roles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.34899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.84899902 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.79000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.29000092 42.92200089 Tm [(ubiquitin-)1(de)-1(p)1(e)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.88999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.38999939 42.92200089 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.52000427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.02000427 42.92200089 Tm [(th)1(roug)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 58.52199936 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.35099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.85099792 58.52199936 Tm [(chain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.82099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.32099915 58.52199936 Tm [(disa)1(sse)-1(mb)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.39199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.89199829 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.16900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.66900635 58.52199936 Tm [(hydro)1(ly)-1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.7749939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.2749939 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.11700439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.61700439 58.52199936 Tm [(ubiquiti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n-subs)1(trat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.28900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.78900146 74.12200165 Tm [(bo)1(n)-1(d)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.89399719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.39399719 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.2009964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.7009964 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.20799255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.70799255 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.01499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.51499939 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.05200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.55200195 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.94799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.44799805 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.44900513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(COP9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.13899994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.63899994 89.72200012 Tm [(signalo)1(some,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.18800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.68800354 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.96499634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.46499634 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.22200012 89.72200012 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.26899719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.76899719 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.7440033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.2440033 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.90400696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.40400696 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.34500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.84500122 89.72200012 Tm [(tr)1(ansfor)1(m)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.73001099 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.23001099 89.72200012 Tm [(gr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ow)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.22200012 105.3219986 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.3409996 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.8409996 105.3219986 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.02300262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.52300262 105.3219986 Tm [(signalling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.84899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.34899902 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.2460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.7460022 105.3219986 Tm [(deubiquitinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.27999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.77999878 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.62199402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.12199402 105.3219986 Tm [(rec)-1(e)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 0.75 m 145.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 17.10000038 m 145.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 33.45000076 m 145.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 49.80000305 m 145.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 66.15000153 m 145.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 82.5 m 145.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 98.84999847 m 145.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 115.19999695 m 145.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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