%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 121 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.41200256 23.67700005 Tm 0 g [(US)1(P)-1(25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18299866 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.18299866 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.88699341 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(USP25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.8789978 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.8789978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.00299835 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.20500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.57899475 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.55900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.93299866 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.40699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26400757 12.82499981 Tm [(25;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.09100342 12.82499981 Tm [(USP21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.72000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(856-1)1(055)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.54100037 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.57600403 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.61700439 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65200806 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.08300781 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.11801147 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.61099243 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.64599609 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.33200073 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.36700439 12.04500008 Tm [(USP25)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 344.04901123 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04800415 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(USP21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.97599983 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UHP3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.07699966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(93)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.42500305 16.35000038 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 121.42500305 94.34999847 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ub)1(iquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.85400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.35400009 11.72200012 Tm [(\(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.59200287 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.09200287 11.72200012 Tm [(19)-1(13)-1(39)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.76499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.26499939 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.8259964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.3259964 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.3010025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.80099487 11.72200012 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.19500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.69500732 11.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.27200317 11.72200012 Tm [(76)-1(-)1(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.79200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.29199219 11.72200012 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.93200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.43200684 11.72200012 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.99100113 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.49099731 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.43199921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.93199921 27.3220005 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.16300201 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.66299438 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.50500488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.00500488 27.3220005 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.47200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.97200012 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.27900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.77900696 27.3220005 Tm [(breakdo)1(wn,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.24099731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.74099731 27.3220005 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.89599991 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.39599991 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.68799973 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.18799973 42.92200089 Tm [(regulat)1(i)-1(o)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.58499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.08499908 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.36199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.86199951 42.92200089 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.2559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.7559967 42.92200089 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.91999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.41999817 42.92200089 Tm [(Ub)1(iquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.27400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.77400208 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.33500671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.83500671 42.92200089 Tm [(rele)-1(a)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.88299561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.38299561 42.92200089 Tm [(fr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(om)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.15499973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.65500069 58.52199936 Tm [(degra)1(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.30599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.80599976 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.27899933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.77899933 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.79100037 58.52199936 Tm [(disa)1(sse)-1(mb)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.86199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.36199951 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.20399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.70399475 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.70500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.20500183 58.52199936 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.51400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.01400757 58.52199936 Tm [(chain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.93000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.43000031 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.99100113 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.49100113 74.12200165 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.3730011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.8730011 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.38500214 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.88500214 74.12200165 Tm [(ubiquitin-)1(spec)-1(ific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.41600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.91600037 74.12200165 Tm [(pro)1(teases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.69500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.19500732 74.12200165 Tm [(\(USPs)1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.95901489 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.45901489 74.12200165 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.22601318 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 89.72200012 Tm [(USP25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.61700058 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.11700058 89.72200012 Tm [(\(Valero)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.84400177 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.34400177 89.72200012 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8030014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.3030014 89.72200012 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.0059967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.5059967 89.72200012 Tm [(19)-1(99)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.61700439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.11700439 89.72200012 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.58000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08000183 89.72200012 Tm [(10)-1(64)-1(44)-1(37]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.48100281 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 0.75 m 121.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 17.10000038 m 121.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 33.45000076 m 121.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 49.80000305 m 121.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 66.15000153 m 121.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 82.5 m 121.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 98.84999847 m 121.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 115.19999695 m 121.05000305 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 423.17498779 209.17498779 l S Q Q q 1 0 0 1 0 602.4619751 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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