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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.98799896 23.67700005 Tm 0 g [(US)1(P)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.60800171 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.60800171 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.31201172 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(USP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.30699921 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.55699921 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.55700684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.30699921 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68099976 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.88300323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.25700378 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.23699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.61099243 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.08500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26400757 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.39500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.76899719 12.82499981 Tm [(UBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.64199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(586-7)1(85)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(USP1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 334.92700195 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.77000427 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.87299919 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O94)-1(78)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(50)-1(52)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 144.67500305 109.94999695 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(ubiquitin-)1(spec)-1(ific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.30799866 11.72200012 Tm [(pro)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ssing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.03000069 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.53000069 27.3220005 Tm [(\(UBP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.41400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.91400146 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.4960022 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.33799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.83799744 27.3220005 Tm [(pro)1(teases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.61700439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.11700439 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.33900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.83900452 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.3999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.8999939 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.875 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.375 27.3220005 Tm [(deubiquitinat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.94400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.44400024 27.3220005 Tm [(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(zyme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.72900009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.22900009 42.92200089 Tm [(\(DU)1(B)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.4620018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.9620018 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.35800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.85800171 42.92200089 Tm [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.37999725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.87999725 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.15699768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.65699768 42.92200089 Tm [(Cys)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.60699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.10699463 42.92200089 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.26699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.76699829 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.02900696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.52900696 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.83599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.33599854 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.89700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.39700317 42.92200089 Tm [(locat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.80500031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.30500031 58.52199936 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.3730011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.8730011 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.15000153 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.65000153 58.52199936 Tm [(cl)-1(eaves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.63600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.13600159 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.13699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.63699341 58.52199936 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.31799316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.81799316 58.52199936 Tm [(moiety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.59100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.09100342 58.52199936 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ubiquitin-)1(fuse)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.26999664 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.76999664 74.12200165 Tm [(precu)-1(r)1(sors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.04699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.54699707 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.82400513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.32400513 74.12200165 Tm [(ubiquitinylated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.35400391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.85400391 74.12200165 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.49299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.99299622 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.79998779 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 89.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.29199982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.79199982 89.72200012 Tm [(deubiquitinat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.93600464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.43600464 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.41099548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.91099548 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.21800232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.71800232 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.65899658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.15899658 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.66000366 89.72200012 Tm [(Fanc)-1(o)1(n)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.13800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(anemia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.43000031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.93000031 105.3219986 Tm [(\(FA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.05500031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.55500031 105.3219986 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.05999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.55999756 105.3219986 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.65699768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.15699768 105.3219986 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.78500366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.28500366 105.3219986 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.88900757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.38900757 105.3219986 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.34298706 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.84298706 105.3219986 Tm [(s)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 0.75 m 144.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 17.10000038 m 144.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 33.45000076 m 144.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 49.80000305 m 144.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 66.15000153 m 144.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 82.5 m 144.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 98.84999847 m 144.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 115.19999695 m 144.30000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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