%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.84500122 23.67700005 Tm 0 g [(UGT2B4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.75100708 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 161.75100708 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 338.45498657 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UG)1(T)-1(2B4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.83300018 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.08300018 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 187.08299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UG)1(T)-1(2B4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.83300018 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20700073 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.40899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.78300476 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.76300049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.13699341 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.61099243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UDP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.6210022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.63899994 12.82499981 Tm [(glu)-1(c)1(u)-1(r)1(o)-1(no)-1(sy)1(l)-1(tr)1(an)-1(sfer)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.26499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.28300476 12.82499981 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.60499573 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.6230011 12.82499981 Tm [(fami)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.43600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.45399475 12.82499981 Tm [(po)-1(lypepti)-1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.59500122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.61300659 12.82499981 Tm [(B4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.45599365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.47399902 12.82499981 Tm [(HLUG25;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.24398804 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 370.26199341 12.82499981 Tm [(UDP)1(GT)-1(H1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(UG)1(T)-1(2B1)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.9640007 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.33800125 30.49699783 Tm [(UDP)1(GT)-1(2)1(B4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.86399841 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.23799896 30.49699783 Tm [(UDP)1(GT)-1(h-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.65299988 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(UG)1(T)-1(2B4)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 287.73699951 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UD)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.08099937 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.58099937 11.72200012 Tm [(glucu)-1(r)1(onosyltransf)1(e)-1(ra)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.9750061 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.25300598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.75300598 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.00100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.50100708 11.72200012 Tm [(po)1(l)-1(yp)1(e)-1(pt)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.34300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.84300232 11.72200012 Tm [(B4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.76800537 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HL)-1(U)1(G25)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.7140007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.2140007 11.72200012 Tm [(UD)1(PGTH1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.55200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.05200195 11.72200012 Tm [(UG)1(T2)-1(B1)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.27000427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.77000427 11.72200012 Tm [(UD)1(PGT2B)-1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.07200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.57200623 11.72200012 Tm [(UD)1(PGTh-)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.21800232 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P06)-1(13)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(26)-1(26)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 128.17500305 16.35000038 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 128.17500305 94.34999847 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UD)1(PGTs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.09899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.59899902 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.11700058 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.61700058 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.45899963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.95899963 11.72200012 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.92900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.42900085 11.72200012 Tm [(impor)1(tance)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.65699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.15699768 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.0980072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.5980072 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.59899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.09899902 11.72200012 Tm [(conj)-1(ug)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.57699585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.07699585 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.35400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.85400391 11.72200012 Tm [(subse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(quent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.30800056 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.80800056 27.3220005 Tm [(eli)-1(minat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.06900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.56900024 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.41100311 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.91100311 27.3220005 Tm [(po)1(ten)-1(t)1(ially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.66200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.16200256 27.3220005 Tm [(to)1(xic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.70599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.20599365 27.3220005 Tm [(xenobiot)1(ic)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.43400574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.93400574 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.21099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.71099854 27.3220005 Tm [(en)-1(d)1(ogeno)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 42.92200089 Tm [(compounds.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.53099823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.03099823 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.29299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.79299927 42.92200089 Tm [(isoz)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.80400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.30400085 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.86500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.36500549 42.92200089 Tm [(active)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.43099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.93099976 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.19900513 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.69900513 42.92200089 Tm [(po)1(l)-1(yhyd)1(roxylated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.45901489 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.95901489 42.92200089 Tm [(estro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gens)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.57500076 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.07500076 58.52199936 Tm [(\(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.84700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.34700012 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.48799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.98799896 58.52199936 Tm [(estriol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.72799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.22799683 58.52199936 Tm [(4-hydro)1(xye)-1(st)1(rone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.3809967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.8809967 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.15800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.65800476 58.52199936 Tm [(2-hydro)1(xye)-1(st)1(riol\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.95401001 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.45401001 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(xenobiot)1(ic)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.48500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.98500061 74.12200165 Tm [(\(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.75700378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.25700378 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.39800262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.89800262 74.12200165 Tm [(4-methylumbel)-1(lif)1(e)-1(ro)1(n)-1(e,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.88400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.38400269 74.12200165 Tm [(1-naph)1(tho)1(l)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.54299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.04299927 74.12200165 Tm [(4-nitr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(op)1(he)-1(no)1(l)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.9469986 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.4469986 89.72200012 Tm [(2-aminoph)1(e)-1(nol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.91400146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.41400146 89.72200012 Tm [(4-hydro)1(xybiphenyl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.37399292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.87399292 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.15100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.65100098 89.72200012 Tm [(men)-1(t)1(hol\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.92001343 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.42001343 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.41900635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.91900635 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.48001099 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 0.75 m 127.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 17.10000038 m 127.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 33.45000076 m 127.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 49.80000305 m 127.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 66.15000153 m 127.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 82.5 m 127.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 98.84999847 m 127.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 115.19999695 m 127.80000305 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>