%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.43299866 23.67700005 Tm 0 g [(UB)1(R7)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.16299438 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.86700439 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBR7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.47100067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.72100067 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.72099304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBR7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.47100067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.84500122 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.04699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.42099762 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.40100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.7749939 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.24899292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.08500671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.45899963 12.82499981 Tm [(li)-1(gase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.58099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.95500183 12.82499981 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.40400696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.77799988 12.82499981 Tm [(compo)-1(nent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.97099304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.34500122 12.82499981 Tm [(n-)-1(r)1(ecogni)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.32400513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.69799805 12.82499981 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.01998901 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.39401245 12.82499981 Tm [(\(p)-1(utative\);)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.04501343 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.41900635 12.82499981 Tm [(C14orf130)] TJ ET EMC /P <> BDC BT 1 0 0 -1 376.0289917 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 1.5 l -0.75 1.5 l h W n q 0 1 -1 0 421.19998169 -4.9000001 cm q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 29.98399925 Tm [(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 47.92299652 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 65.86199951 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 83.80099487 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 101.73999786 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 119.67900085 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 137.61799622 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 155.55699158 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 173.4960022 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 191.43499756 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 209.37399292 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 227.31300354 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 245.2519989 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 263.19100952 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 281.13000488 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 299.06900024 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 317.00802612 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 334.94702148 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 352.88601685 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 370.82501221 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 388.76400757 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 406.70300293 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 424.64199829 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 442.58102417 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 460.52001953 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 478.45901489 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 496.39801025 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 514.3369751 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 532.27600098 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 550.21496582 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 568.1539917 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 586.09295654 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 604.03198242 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 621.9710083 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 639.90997314 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 657.84899902 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 675.78796387 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 693.72698975 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 711.66595459 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 729.60498047 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 747.54400635 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 765.48297119 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 783.42199707 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 801.36096191 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 819.29998779 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 837.23895264 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 855.17797852 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 873.11700439 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 891.05596924 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 908.99499512 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 926.93395996 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 944.87298584 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 962.81201172 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 980.75097656 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 998.69000244 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1016.62896729 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1034.56799316 Tm [(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1052.50708008 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1070.44604492 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1088.38500977 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1106.32409668 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1124.26306152 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1142.20202637 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1160.14099121 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1178.08007813 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1196.01904297 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1213.95800781 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1231.89709473 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1249.83605957 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1267.77502441 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1285.71398926 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1303.65307617 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1321.59204102 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1339.53100586 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1357.47009277 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1375.40905762 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1393.34802246 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1411.2869873 Tm [(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1429.22607422 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1447.16503906 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1465.10400391 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1483.04309082 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1500.98205566 Tm [(U)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1518.92102051 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1536.85998535 Tm [(R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1554.79907227 Tm [(7)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 4.5619998 1554.79907227 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 0.5 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 0.5 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 0.75 m 426.3500061 0.75 l S Q Q q /GS2 gs 1 g -1.45000005 274.63400269 m 416.75 274.63400269 l 416.75 305.83401489 l -1.45000005 305.83401489 l h f* Q q /GS2 gs 1 g -1.45000005 305.83401489 m 416.75 305.83401489 l 416.75 337.0340271 l -1.45000005 337.0340271 l h f* Q q 1 0 0 1 0 274.63400269 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 337.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 364.97299194 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.48799896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.98799896 11.72200012 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.78199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.28199768 11.72200012 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.50800323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.00800323 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.69700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.19700623 11.72200012 Tm [(n-rec)-1(o)1(gnin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.65800476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.15800476 11.72200012 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.43600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.93600464 11.72200012 Tm [(\(put)1(ative\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.14801025 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C14)-1(or)1(f13)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.68799973 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8N8)-1(06)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.76300049 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(04)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 122.92500305 16.35000038 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 122.17500305 0.75 l 122.17500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 123.17500305 -0.25 l 123.17500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.92500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 122.92500305 141.1499939 l h f* Q q 1 0 0 1 122.55000305 0 cm -0.625 -0.25 m 300.875 -0.25 l 300.875 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.84400177 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.34400177 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.40499878 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.9260025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.4260025 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.38699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.88699341 11.72200012 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.9960022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.4960022 11.72200012 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.39300537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.89300537 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.98999023 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.48999023 11.72200012 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.03399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.48699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.98699951 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.82899857 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.32899857 27.3220005 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.87599945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.37599945 27.3220005 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.21700287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.71700287 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.65799713 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.15799713 27.3220005 Tm [(conc)-1(ert)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.3480072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.8480072 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.92300415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.42300415 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.40299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.90299988 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.39300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.89300537 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.05099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.55099487 27.3220005 Tm [(ab)1(n)-1(o)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.3029995 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.77600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.27600098 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.55400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.05400085 42.92200089 Tm [(dest)1(ru)-1(ctio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.11399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.61399841 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.42100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.92100525 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.46499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.96499634 42.92200089 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.45199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.95199585 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.79400635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.29400635 42.92200089 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.84100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.34100342 42.92200089 Tm [(invol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.58699989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.08699989 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.02799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.52799988 58.52199936 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.1989975 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.6989975 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.21700287 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.71700287 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.71800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.21800232 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.27799988 58.52199936 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.82501221 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.32501221 58.52199936 Tm [(\(E1s\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.89498901 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 74.12200165 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.58799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.08799744 74.12200165 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.63499451 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.13499451 74.12200165 Tm [(\(E2s\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.53900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.03900146 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.31599426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.81599426 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.81700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.31700134 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(ligases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.00600052 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.50600052 89.72200012 Tm [(\(E3s\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.0759964 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.5759964 89.72200012 Tm [(Ub)1(r7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.75800323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.25800323 89.72200012 Tm [(\(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.94500732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.44500732 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.7519989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.2519989 89.72200012 Tm [(ligas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.04600525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.54600525 89.72200012 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.77200317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.27200317 89.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.96099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.46099854 89.72200012 Tm [(n-r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ec)-1(og)1(ni)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.58499908 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.08499908 105.3219986 Tm [(7\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.53499985 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.03499985 105.3219986 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.29199982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.79199982 105.3219986 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.61100006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.11100006 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2519989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.7519989 105.3219986 Tm [(C14)-1(or)1(f13)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.44000244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.94000244 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.0980072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.5980072 105.3219986 Tm [(N-r)1(e)-1(cognin-7,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.16799927 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.66799927 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.22900391 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.72900391 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.70401001 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.20401001 105.3219986 Tm [(42)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.0369873 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06999969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56999969 120.92199707 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.20999908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.70999908 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.01699829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.51699829 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.73899841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.23899841 120.92199707 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.45399475 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.95399475 120.92199707 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.32800293 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.82800293 120.92199707 Tm [(UBR-)1(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.93400574 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.43400574 120.92199707 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.31300354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.81300354 120.92199707 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.17401123 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.67401123 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.95098877 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37400055 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.87400055 136.52200317 Tm [(PHD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.1969986 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6969986 136.52200317 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.57600021 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.0759964 136.52200317 Tm [(finger.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.60299683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.10299683 136.52200317 Tm [(Par)1(tic)-1(ip)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.44999695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.94999695 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.89100647 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.39100647 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.69799805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.19799805 136.52200317 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.52301025 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.02301025 136.52200317 Tm [(eve)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.0249939 136.52200317 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 0.75 m 122.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 17.10000038 m 122.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 33.45000076 m 122.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 49.80000305 m 122.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 66.15000153 m 122.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 82.5 m 122.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 98.84999847 m 122.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.55000305 115.19999695 m 122.55000305 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 255.97497559 m 423.17498779 255.97497559 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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