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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.43299866 23.67700005 Tm 0 g [(UB)1(R2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.16299438 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.86700439 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBR2)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 86.47100067 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.72100067 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.72099304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBR2)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 86.47100067 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 88.84500122 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 122.04699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 124.42099762 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 184.40100098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 186.7749939 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 221.24899292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 108.60399628 12.82499981 Tm [(protein)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 139.98599243 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 147.26100159 12.82499981 Tm [(li)-1(gase)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 171.38299561 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 178.65800476 12.82499981 Tm [(E3)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 189.10699463 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 196.38200378 12.82499981 Tm [(compo)-1(nent)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 245.57499695 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 252.8500061 12.82499981 Tm [(n-)-1(r)1(ecogni)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 298.82901001 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 306.10400391 12.82499981 Tm [(2;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 314.23498535 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 321.51000977 12.82499981 Tm [(C6orf133;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 363.60699463 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 370.88198853 12.82499981 Tm [(bA49A)1(4.)-1(1)1(;)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 415.29699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(dJ242G1)1(.)-1(1;)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 47.55799866 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 49.93199921 30.49699783 Tm [(dJ392M17)1(.)-1(3)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 102.35500336 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 232.43400574 m 416.75 232.43400574 l 416.75 263.63400269 l -1.45000005 263.63400269 l h f* Q q 1 0 0 1 0 232.43400574 cm /P <</MCID 58 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 263.63400269 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 291.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 62 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(240-4)1(39)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(UBR2)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 335.92401123 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 320.51199341 m 416.75 320.51199341 l 416.75 351.71200562 l -1.45000005 351.71200562 l h f* Q q /GS2 gs 1 g -1.45000005 351.71200562 m 416.75 351.71200562 l 416.75 382.91201782 l -1.45000005 382.91201782 l h f* Q q 1 0 0 1 0 320.51199341 cm /P <</MCID 90 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <</Lang (zh-CN) /MCID 92 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 382.9119873 cm /P <</MCID 94 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 410.85101318 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 74.48799896 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 78.98799896 11.72200012 Tm [(ligase)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 103.78199768 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 108.28199768 11.72200012 Tm [(E3)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 118.50800323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 123.00800323 11.72200012 Tm [(component)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 172.69700623 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 177.19700623 11.72200012 Tm [(n-rec)-1(o)1(gnin)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 224.65800476 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 229.15800476 11.72200012 Tm [(2)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 234.43600464 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 114 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C6orf133)-1(;)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 41.57699966 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 46.07699966 11.72200012 Tm [(bA)1(4)-1(9A4.1;)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 89.93399811 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 94.43399811 11.72200012 Tm [(dJ242)-1(G1.1;)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 141.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 145.66999817 11.72200012 Tm [(dJ392)-1(M17)-1(.3)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 197.61799622 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 124 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 125 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8IWV8)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 35.77999878 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 130 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(64)-1(51)-1(2)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 133 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 134 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 135 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 151 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 154 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 155 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 159 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 160 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 173 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 174 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 133.42500305 78.75 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 175 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 98.71600342 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 103.21600342 11.72200012 Tm [(E3)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 113.44200134 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 117.94200134 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 156.6230011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 161.1230011 11.72200012 Tm [(ligas)1(e)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 185.91700745 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 190.41700745 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 199.25900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 203.75900269 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 217.75999451 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 222.25999451 11.72200012 Tm [(N-end)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 249.88000488 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 254.38000488 11.72200012 Tm [(rule)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 270.86401367 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 275.36401367 11.72200012 Tm [(p)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(rot)1(e)-1(o)1(ly)-1(t)1(ic)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 40.75899887 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 45.25899887 27.3220005 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 81.72000122 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 86.22000122 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 103.44200134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 107.94200134 27.3220005 Tm [(ta)1(rgets)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 138.08799744 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 142.58799744 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 178.06100464 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 182.56100464 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 200.95700073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 205.45700073 27.3220005 Tm [(dest)1(abilizing)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 259.86999512 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 264.36999512 27.3220005 Tm [(N-t)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ermin)-1(a)1(l)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 32.28699875 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 36.78699875 42.92200089 Tm [(residues)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 72.46600342 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 76.96600342 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 89.2440033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 93.7440033 42.92200089 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(y)-1(la)1(tion)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 172.26100159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 176.76100159 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 193.03799438 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 197.53799438 42.92200089 Tm [(pro)1(teasome-media)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ted)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 14.2159996 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 18.7159996 58.52199936 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 73.66100311 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 78.16100311 58.52199936 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 124.88400269 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 129.38400269 58.52199936 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 162.29899597 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 166.79899597 58.52199936 Tm [(results)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 194.96800232 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 199.46800232 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 207.40899658 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 211.90899658 58.52199936 Tm [(multiple)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 247.28100586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 251.78100586 58.52199936 Tm [(tr)1(ansc)-1(r)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ipt)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 11.49600029 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 15.99600029 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 51.73199844 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 0.75 m 133.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 17.10000038 m 133.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 33.45000076 m 133.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 49.80000305 m 133.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 66.15000153 m 133.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 82.5 m 133.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 98.84999847 m 133.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 115.19999695 m 133.05000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 423.17498779 193.57499695 l S Q Q q 1 0 0 1 0 604.80102539 cm /P <</MCID 243 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 110 0 R/Length 30656>>stream
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