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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.22399902 23.67700005 Tm 0 g [(UB)1(L7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.3710022 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.3710022 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.07501221 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBL7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.18399811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.43399811 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.43400574 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBL7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.18399811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.55799866 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.76000214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.13400269 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.11399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.48800659 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.96200562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.51999664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.89399719 12.82499981 Tm [(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.0249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.39900208 12.82499981 Tm [(TC)-1(B)1(A1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.03300476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.40699768 12.82499981 Tm [(BMSC)-1(-U)1(b)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.41099548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-380)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(UBL7)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 325.69699097 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.97700119 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.47700119 11.72200012 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.75499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TCB)-1(A)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.60400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.10400009 11.72200012 Tm [(BMS)-1(C-)1(Ub)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.62599945 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(S82)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.63999939 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(07)-1(91)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 137.92500305 109.94999695 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ub)1(iquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.85400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.35400009 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.91500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.41500092 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.93599701 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.43599701 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.39700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.89700317 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.65899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.15899658 11.72200012 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.39199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.89199829 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.11399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.61399841 11.72200012 Tm [(ta)1(rgets)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.75999451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.25999451 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.73300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.77799988 27.3220005 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05599976 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.21399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.71399689 27.3220005 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.55500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05499268 27.3220005 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.38800049 27.3220005 Tm [(func)-1(t)1(ions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.46099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.96099854 27.3220005 Tm [(UBL7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.22399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.72399902 27.3220005 Tm [(\(ORF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.72099304 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.22099304 27.3220005 Tm [(name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.28100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(SB)-1(132)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.68099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.18099976 42.92200089 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.09799957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.59799957 42.92200089 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.96899414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.46899414 42.92200089 Tm [(pro)1(tein)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55299377 42.92200089 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.30999756 42.92200089 Tm [(named)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.1269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.6269989 42.92200089 Tm [(bo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.74899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.24899292 42.92200089 Tm [(marr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 58.52199936 Tm [(st)1(romal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.80799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.30799866 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.71800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.21800232 58.52199936 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.58900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.08900452 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.39599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.89599609 58.52199936 Tm [(\(BMS)-1(C-)1(Ub)1(P\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.42999268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.92999268 58.52199936 Tm [(capab)1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.39001465 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.89001465 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.73199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.14400101 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.64400101 74.12200165 Tm [(ubiquitin.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.49099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.99099731 74.12200165 Tm [(BMS)-1(C-)1(Ub)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.51300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.01300049 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.32000732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.82000732 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.3809967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8809967 74.12200165 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.16299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.66299438 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.37399292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.87399292 74.12200165 Tm [(bo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.9960022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.4960022 74.12200165 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(arr)1(ow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.67499924 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.17499924 89.72200012 Tm [(st)1(romal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.65499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.15499878 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.73100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.23100281 89.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.97799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.47799683 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.95300293 89.72200012 Tm [(ubiquitin-)1(associated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.65499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.15499878 89.72200012 Tm [(\(UBA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.86499023 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.36499023 89.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(oma)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06999969 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56999969 105.3219986 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.89799881 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.39799881 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.39899826 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.89899826 105.3219986 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.91999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.41999817 105.3219986 Tm [(terminus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.40200043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.90200043 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.12399292 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.62399292 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.30599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.80599976 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.31300354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.81300354 105.3219986 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.88299561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.38299561 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.32400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.82400513 105.3219986 Tm [(link)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.75799561 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 0.75 m 137.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 17.10000038 m 137.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 33.45000076 m 137.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 49.80000305 m 137.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 66.15000153 m 137.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 82.5 m 137.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 98.84999847 m 137.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 115.19999695 m 137.55000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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