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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.38800049 23.67700005 Tm 0 g [(UB)1(E2Q2)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 151.20700073 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 162.20700073 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 338.91101074 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBE2Q2)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 98.28399658 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.53399658 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 187.53399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2Q2)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 98.28399658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 100.65799713 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 133.86000061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 136.23399353 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 196.21400452 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 198.58799744 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 233.06199646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 65.37400055 12.82499981 Tm [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 106.07700348 12.82499981 Tm [(con)-1(jugatin)-1(g)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 155.95700073 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 158.33099365 12.82499981 Tm [(enzym)1(e)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 191.58399963 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 193.95799255 12.82499981 Tm [(E2Q)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 211.47200012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 213.84599304 12.82499981 Tm [(fami)-1(ly)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 240.03999329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 242.41400146 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 278.81500244 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 281.18899536 12.82499981 Tm [(2)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 286.51098633 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <</MCID 52 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(176-3)1(75)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(UBE2Q2)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAADC 10 Tf 1 0 0 -1 403.72000122 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <</MCID 84 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <</MCID 88 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 94.69400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 99.19400024 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 132.57499695 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 137.07499695 11.72200012 Tm [(E2Q)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 154.63600159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 159.13600159 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 185.21800232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 189.71800232 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 225.98199463 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 230.48199463 11.72200012 Tm [(2)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 235.75999451 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 107 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 108 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WVN8)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 40.45199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 114 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(17)-1(70)-1(8)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 117 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 118 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 135 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 138 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 139 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 143 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 144 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 145 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 157 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 158 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 135.67500305 125.55000305 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 159 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UBE2Q2)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 35.20500183 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 39.70500183 11.72200012 Tm [(\(Ub)1(iquitin-conju)-1(g)1(at)1(i)-1(ng)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 137.97099304 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 142.47099304 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 175.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 180.352005 11.72200012 Tm [(E2)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 190.57800293 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 195.07800293 11.72200012 Tm [(Q2\))] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 210.69599915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 215.19599915 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 221.75700378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 226.25700378 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 231.23199463 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 235.73199463 11.72200012 Tm [(37)-1(5)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 251.56500244 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 256.06500244 11.72200012 Tm [(amin)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(o)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 5.72200012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 10.22200012 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 27.86199951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 32.36199951 27.3220005 Tm [(cy)-1(t)1(oplas)1(mi)-1(c)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 83.33899689 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 87.83899689 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 119.14600372 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 123.64600372 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 140.86799622 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 145.36799622 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 151.92900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 156.42900085 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 192.79800415 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 197.29800415 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 205.23899841 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 209.73899841 27.3220005 Tm [(ubiquitin-)1(me)-1(dia)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ted)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 14.2159996 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 18.7159996 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 50.02299881 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 54.52299881 42.92200089 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 109.46800232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 113.96800232 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 175.81199646 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 180.31199646 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 186.8730011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 191.3730011 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 201.89399719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 206.39399719 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 249.35499573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 253.85499573 42.92200089 Tm [(mec)-1(h)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(anism)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 25.51499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 30.01499939 58.52199936 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 64.91200256 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 69.41200256 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 94.50900269 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 99.00900269 58.52199936 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 121.5530014 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 126.0530014 58.52199936 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 155.53999329 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 160.03999329 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 168.88200378 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 173.38200378 58.52199936 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 210.92900085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 215.42900085 58.52199936 Tm [(act)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 228.27000427 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 232.77000427 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 240.71099854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 245.21099854 58.52199936 Tm [(conc)-1(ert)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 277.40100098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 9.07499981 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 13.57499981 74.12200165 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 39.55500031 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 44.05500031 74.12200165 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 90.54499817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 95.04499817 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 104.20300293 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 108.70300293 74.12200165 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 149.93200684 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 154.43200684 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 189.90499878 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 194.40499878 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 206.68299866 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 211.18299866 74.12200165 Tm [(dest)1(ru)-1(ctio)1(n)-1(.)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 262.24301147 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 266.74301147 74.12200165 Tm [(Th)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 5.10599995 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 9.60599995 89.72200012 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 32.15000153 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 36.65000153 89.72200012 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 66.13700104 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 70.63700104 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 79.47899628 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 83.97899628 89.72200012 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 121.52600098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 126.02600098 89.72200012 Tm [(involved)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 162.39500427 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 166.89500427 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 174.83599854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 179.33599854 89.72200012 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 240.00700378 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 244.50700378 89.72200012 Tm [(are)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 258.0249939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 262.5249939 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 276.52600098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 84.55999756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 89.05999756 105.3219986 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 126.60700226 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 131.10699463 105.3219986 Tm [(\(E1s\),)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 153.67700195 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 158.17700195 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 172.17799377 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 176.67799377 105.3219986 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 270.76501465 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 37.54700089 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 42.04700089 120.92199707 Tm [(\(E2s\))] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 62.45100021 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 66.9509964 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 83.22799683 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 87.72799683 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 101.72899628 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 106.22899628 120.92199707 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 180.11000061 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 184.61000061 120.92199707 Tm [(ligas)1(e)-1(s)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 213.57000732 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 218.07000732 120.92199707 Tm [(\(E3s\).)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 240.63999939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 245.13999939 120.92199707 Tm [(One)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 263.12701416 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 267.62701416 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 276.46899414 120.92199707 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 0.75 m 135.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 17.10000038 m 135.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 33.45000076 m 135.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 49.80000305 m 135.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 66.15000153 m 135.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 82.5 m 135.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 98.84999847 m 135.30000305 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.0249939 m 423.17498779 224.0249939 l S Q Q Q 1 0 0 -1 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