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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.29299927 23.67700005 Tm 0 g [(UB)1(E2J2)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 147.30299377 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 158.30299377 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.00698853 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBE2J2)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 94.56700134 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.81700134 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.81700134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2J2)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 94.56700134 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 96.94100189 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 130.14300537 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 132.51699829 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 192.49699402 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 194.8710022 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 229.34500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin-)-1(c)1(o)-1(nju)-1(g)1(ati)-1(ng)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 154.42399597 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 156.79800415 12.82499981 Tm [(enzym)1(e)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 190.05099487 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 192.42500305 12.82499981 Tm [(E2,)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 205.4940033 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 207.86799622 12.82499981 Tm [(J2;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 219.34700012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 221.72099304 12.82499981 Tm [(NCU)1(BE)-1(2)1(;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 259.8039856 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 262.17800903 12.82499981 Tm [(NCU)1(BE)-1(-2;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 303.47601318 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 305.8500061 12.82499981 Tm [(PRO21)1(21)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 345.21499634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <</MCID 51 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 273.63400269 m 416.75 273.63400269 l 416.75 291.57299805 l -1.45000005 291.57299805 l h f* Q q 1 0 0 1 0 273.63400269 cm /P <</MCID 55 >> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 274.18399048 1.25 l 274.18399048 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 274.18399048 1.25 m 276.84698486 1.25 l 276.84698486 16.68799973 l 274.18399048 16.68799973 l h f* Q q /GS2 gs 1 g 276.84698486 1.25 m 303.91699219 1.25 l 303.91699219 16.68799973 l 276.84698486 16.68799973 l h f* Q q /GS2 gs 1 g 303.91699219 1.25 m 306.57998657 1.25 l 306.57998657 16.68799973 l 303.91699219 16.68799973 l h f* Q q /GS2 gs 1 g 306.57998657 1.25 m 328.38598633 1.25 l 328.38598633 16.68799973 l 306.57998657 16.68799973 l h f* Q q /GS2 gs 1 g 328.38598633 1.25 m 331.04898071 1.25 l 331.04898071 16.68799973 l 328.38598633 16.68799973 l h f* Q q /GS2 gs 1 g 331.04901123 1.25 m 339.89102173 1.25 l 339.89102173 16.68799973 l 331.04901123 16.68799973 l h f* Q q /GS2 gs 1 g 339.89099121 1.25 m 342.5539856 1.25 l 342.5539856 16.68799973 l 339.89099121 16.68799973 l h f* Q q /GS2 gs 1 g 342.5539856 1.25 m 372.5949707 1.25 l 372.5949707 16.68799973 l 342.5539856 16.68799973 l h f* Q q /GS2 gs 1 g 372.59500122 1.25 m 375.25799561 1.25 l 375.25799561 16.68799973 l 372.59500122 16.68799973 l h f* Q q /GS2 gs 1 g 375.25799561 1.25 m 406.69198608 1.25 l 406.69198608 16.68799973 l 375.25799561 16.68799973 l h f* Q EMC /P <</MCID 56 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(11)-1(0-25)-1(9)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 274.18399048 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 276.84698486 12.89099979 Tm [(amino)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 303.91699219 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 306.57998657 12.89099979 Tm [(acids)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 328.38598633 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 331.04901123 12.89099979 Tm [(of)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 339.89099121 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 342.5539856 12.89099979 Tm [(human)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 372.59500122 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 375.25799561 12.89099979 Tm [(UBE2J2)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 406.69198608 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 291.57299805 m 416.75 291.57299805 l 416.75 322.77301025 l -1.45000005 322.77301025 l h f* Q q 1 0 0 1 0 291.57299805 cm /P <</MCID 84 >> BDC BT /FAAADC 10 Tf 1 0 0 -1 0 19.95700073 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 322.77301025 m 416.75 322.77301025 l 416.75 353.97302246 l -1.45000005 353.97302246 l h f* Q q 1 0 0 1 0 322.77301025 cm /P <</MCID 85 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 353.97299194 cm /P <</MCID 88 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 381.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 94.08699799 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 98.58699799 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 131.96800232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 136.46800232 11.72200012 Tm [(E2,)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 148.86099243 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 153.36099243 11.72200012 Tm [(J2)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 162.20300293 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 102 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NCUBE2;)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 38.09600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 42.59600067 11.72200012 Tm [(NCUBE-)1(2)-1(;)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 84.58599854 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 89.08599854 11.72200012 Tm [(PRO212)-1(1)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 128.91400146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 110 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8N2)-1(K1)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 36.19800186 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 116 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 117 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(13)-1(43)-1(0)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 120 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 137 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 140 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 141 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 145 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 146 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 128.92500305 16.35000038 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 147 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 159 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 160 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 128.92500305 125.55000305 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 272.06698608 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ular)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 16.35199928 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 20.85199928 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 69.96099854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 74.46099854 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 86.73899841 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 91.23899841 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 130.91700745 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 135.41700745 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 176.64599609 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 181.14599609 27.3220005 Tm [(or)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 190.30400085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 194.80400085 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 241.29400635 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 245.79400635 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 281.26699829 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 12.27799988 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 16.77799988 42.92200089 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 71.72299957 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 76.22299957 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 138.06700134 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 142.56700134 42.92200089 Tm [(involves)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 177.34500122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 181.84500122 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 190.17300415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 194.67300415 42.92200089 Tm [(least)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 214.66799927 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 219.16799927 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 241.71200562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 246.21200562 42.92200089 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 275.69900513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 280.19900513 42.92200089 Tm [(o)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(f)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 3.11999989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 7.61999989 58.52199936 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 47.33300018 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 51.83300018 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 136.39300537 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 140.89300537 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 180.60600281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 185.10600281 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 194.26400757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 198.76400757 58.52199936 Tm [(E1s,)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 215.32299805 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 219.82299805 58.52199936 Tm [(ubiquitin-)1(c)-1(onju)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ga)1(ting)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 27.78199959 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 32.2820015 74.12200165 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 71.99500275 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 76.49500275 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 85.65299988 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 90.15299988 74.12200165 Tm [(E2s,)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 106.71199799 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 111.21199799 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 127.48899841 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 131.98899841 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 205.86999512 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 210.36999512 74.12200165 Tm [(ligases,)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 241.4960022 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 245.9960022 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 255.15400696 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 259.6539917 74.12200165 Tm [(E3s.)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 276.2130127 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 280.7130127 74.12200165 Tm [(T)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(his)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 12.10299969 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 16.60300064 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 38.11899948 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 42.61899948 89.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 78.53600311 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 83.03600311 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 88.01100159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 92.51100159 89.72200012 Tm [(member)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 128.7749939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 133.2749939 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 142.11700439 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 146.61700439 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 160.61799622 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 165.11799622 89.72200012 Tm [(E2)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 175.34399414 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 179.84399414 89.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 273.93099976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 278.43099976 89.72200012 Tm [(e)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nzyme)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 28.27400017 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 32.77399826 105.3219986 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 61.02199936 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 65.52200317 105.3219986 Tm [(This)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 82.78399658 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 87.28399658 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 120.66500092 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 125.16500092 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 131.72599792 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 136.22599792 105.3219986 Tm [(located)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 168.04699707 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 172.54699707 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 180.48800659 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 184.98800659 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 198.98899841 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 203.48899841 105.3219986 Tm [(membrane)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 250.272995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 254.772995 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 263.61499023 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 268.11499023 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 282.11599731 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 54.75600052 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 59.25600052 120.92199707 Tm [(reticu)-1(lum.)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 102.14700317 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 106.64700317 120.92199707 Tm [(Multiple)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 142.3789978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 146.8789978 120.92199707 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 199.4019928 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 203.9019928 120.92199707 Tm [(splice)-1(d)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 233.98300171 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 238.48300171 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 279.40499878 120.92199707 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 0.75 m 128.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 17.10000038 m 128.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 33.45000076 m 128.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 49.80000305 m 128.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 66.15000153 m 128.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 82.5 m 128.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 98.84999847 m 128.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 115.19999695 m 128.55000305 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 423.17498779 240.375 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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