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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.75 23.67700005 Tm 0 g [(UB)1(E2D1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 158.84500122 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.54901123 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBE2D1)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 97.67900085 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.92900085 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.92900085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2D1)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 97.67900085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 100.0530014 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 133.25500488 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 135.6289978 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 195.60899353 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 197.98300171 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 232.45700073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(con)-1(jugatin)-1(g)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 153.58299255 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 155.95700073 12.82499981 Tm [(enzym)1(e)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 189.21000671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 191.58399963 12.82499981 Tm [(E2)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 202.03300476 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 204.40699768 12.82499981 Tm [(D1;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 218.9980011 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 221.37199402 12.82499981 Tm [(SF)-1(T;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 238.94700623 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 241.32099915 12.82499981 Tm [(UBCH5;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 274.04098511 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 276.41500854 12.82499981 Tm [(UBC4/5;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 311.97000122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 314.34399414 12.82499981 Tm [(UBCH5A)1(;)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 353.14001465 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 355.51400757 12.82499981 Tm [(E2\(17\)KB1)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 399.46200562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <</MCID 57 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-147)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(UBE2D1)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAADC 10 Tf 1 0 0 -1 392.47198486 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <</MCID 89 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <</Lang (zh-CN) /MCID 91 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <</MCID 93 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 97 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 94.69400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 99.19400024 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 132.57499695 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 137.07499695 11.72200012 Tm [(E2)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 147.30099487 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 151.80099487 11.72200012 Tm [(D1)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 163.93400574 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 109 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SFT)-1(;)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 17.3010006 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 21.8010006 11.72200012 Tm [(UBCH5)-1(;)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 54.5929985 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 59.0929985 11.72200012 Tm [(UBC4/)-1(5;)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 94.04699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 98.54699707 11.72200012 Tm [(UBCH5)-1(A)1(;)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 137.67199707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 142.17199707 11.72200012 Tm [(E2\(1)-1(7\)KB1)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 185.60299683 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 120 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 121 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 122 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P51)-1(66)-1(8)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 124 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 127 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 128 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(05)-1(98)-1(0)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 130 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 131 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 132 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 148 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 151 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 152 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 156 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 157 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 158 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 170 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 171 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 113.17500305 109.94999695 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 310.625 -0.25 l 310.625 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 172 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 272.06698608 11.72200012 Tm [(ce)-1(llula)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(r)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 3.43700004 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 7.9369998 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 57.04600143 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 61.54600143 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 73.8239975 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 78.3239975 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 118.0019989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 122.5019989 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 163.73100281 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 168.23100281 27.3220005 Tm [(or)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 177.38900757 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 181.88900757 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 228.3789978 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 232.8789978 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 268.35198975 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 272.85198975 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 285.13000488 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 289.63000488 27.3220005 Tm [(de)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(gr)1(adat)1(ion.)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 44.08200073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 48.58200073 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 110.4260025 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 114.9260025 42.92200089 Tm [(involves)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 149.70399475 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 154.20399475 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 162.53199768 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 167.03199768 42.92200089 Tm [(least)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 187.0269928 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 191.5269928 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 214.07099915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 218.57099915 42.92200089 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 248.05799866 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 252.55799866 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 261.3999939 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 265.8999939 42.92200089 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(s:)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 6.33300018 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 10.83300018 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 95.39299774 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 99.89299774 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 139.60600281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 144.10600281 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 153.26400757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 157.76400757 58.52199936 Tm [(E1s,)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 174.32299805 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 178.82299805 58.52199936 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 272.91000366 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 277.41000366 58.52199936 Tm [(en)-1(z)1(y)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mes,)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 19.87199974 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 24.37199974 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 33.52999878 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 38.02999878 74.12200165 Tm [(E2s,)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 54.5890007 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 59.0890007 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 75.36599731 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 79.86599731 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 153.74699402 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 158.24699402 74.12200165 Tm [(ligas)1(e)-1(s,)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 189.3730011 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 193.8730011 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 203.03100586 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 207.53100586 74.12200165 Tm [(E3s.)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 224.08999634 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 228.58999634 74.12200165 Tm [(This)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 245.852005 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 250.352005 74.12200165 Tm [(gene)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 271.86801147 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 276.36801147 74.12200165 Tm [(en)-1(co)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(des)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 15.02900028 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 19.52899933 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 24.50399971 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 29.00399971 89.72200012 Tm [(member)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 65.26799774 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 69.76799774 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 78.61000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 83.11000061 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 97.11100006 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 101.61100006 89.72200012 Tm [(E2)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 111.83699799 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 116.33699799 89.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 210.42399597 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 214.92399597 89.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 248.30499268 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 252.80499268 89.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 281.05300903 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 285.55300903 89.72200012 Tm [(Thi)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 42.04700089 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 46.54700089 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 53.10800171 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 57.60800171 105.3219986 Tm [(cl)-1(o)1(se)-1(ly)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 86.66899872 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 91.16899872 105.3219986 Tm [(related)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 121.29799652 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 125.79799652 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 134.8730011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 139.3730011 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 144.3480072 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 148.8480072 105.3219986 Tm [(st)1(i)-1(mulat)1(or)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 192.62199402 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 197.12199402 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 205.96400452 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 210.46400452 105.3219986 Tm [(iron)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 227.56300354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 232.06300354 105.3219986 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 271.79800415 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 276.29800415 105.3219986 Tm [(\(SFT)-1(\),)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 299.61099243 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 0.75 m 112.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 17.10000038 m 112.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 33.45000076 m 112.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 49.80000305 m 112.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 66.15000153 m 112.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 82.5 m 112.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 98.84999847 m 112.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 115.19999695 m 112.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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