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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.95999908 23.67700005 Tm 0 g [(UB)1(A6)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.63600159 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 324.33999634 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBA)1(6)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 86.84500122 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 92.09500122 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.09500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBA)1(6)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 86.84500122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 89.21900177 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 122.42099762 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 124.79499817 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 184.7749939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 187.14900208 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 221.6230011 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin-)-1(li)-1(k)1(e)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 119.36100006 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 121.73500061 12.82499981 Tm [(mod)-1(ifi)-1(e)1(r)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 158.08500671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 160.45899963 12.82499981 Tm [(activatin)-1(g)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 202.01300049 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 204.38699341 12.82499981 Tm [(enzym)1(e)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 237.63999939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 240.01400757 12.82499981 Tm [(6;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 248.14500427 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 250.51899719 12.82499981 Tm [(E1-L)-1(2;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 276.72799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 279.10198975 12.82499981 Tm [(MOP-4;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 311.80200195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 314.17599487 12.82499981 Tm [(UBE1L2)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 346.80899048 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <</MCID 52 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 56 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(190-3)1(89)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(UBA)1(6)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 336.24499512 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <</MCID 84 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <</MCID 88 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 57.37099838 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 61.87099838 11.72200012 Tm [(mod)1(i)-1(f)1(ie)-1(r)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 98.23600006 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 102.73600006 11.72200012 Tm [(activat)1(ing)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 144.72099304 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 149.22099304 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 182.602005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 187.102005 11.72200012 Tm [(6)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 192.38000488 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 104 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 105 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(E1-L2;)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 26.18300056 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 30.68300056 11.72200012 Tm [(MOP-)1(4)-1(;)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 63.65499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 68.15499878 11.72200012 Tm [(UBE1L2)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 100.64399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 112 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(A0AVT1)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 34.4659996 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 118 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(31)-1(63)-1(7)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 122 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 139 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 142 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 143 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 147 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 148 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 149 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 162 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 115.42500305 94.34999847 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 163 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 54.68600082 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 59.18600082 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 68.02799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 72.52799988 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 108.00099945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 112.50099945 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 130.89700317 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 135.39700317 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 174.07800293 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 178.57800293 11.72200012 Tm [(\(UBB;)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 201.76400757 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 206.26400757 11.72200012 Tm [(MIM)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 226.4960022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 230.9960022 11.72200012 Tm [(19)-1(13)-1(39)-1(\))] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 265.66900635 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 270.16900635 11.72200012 Tm [(or)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 279.32699585 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 283.82699585 11.72200012 Tm [(ubi)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(quitin-)1(l)-1(ike)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 43.68199921 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 48.18199921 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 83.65499878 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 88.15499878 27.3220005 Tm [(controls)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 123.00800323 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 127.50800323 27.3220005 Tm [(many)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 151.2250061 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 155.7250061 27.3220005 Tm [(signaling)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 194.65600586 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 199.15600586 27.3220005 Tm [(ne)-1(t)1(wo)1(rk)-1(s)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 238.49099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 242.99099731 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 259.26800537 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 263.76800537 27.3220005 Tm [(requires)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 298.71798706 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 4.9749999 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 9.47500038 42.92200089 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 94.03500366 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 98.53500366 42.92200089 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 131.91600037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 136.41600037 42.92200089 Tm [(\(E1\),)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 154.82000732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 159.32000732 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 164.29499817 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 168.79499817 42.92200089 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 207.47599792 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 211.97599792 42.92200089 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 263.48901367 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 267.98901367 42.92200089 Tm [(en)-1(z)1(y)-1(m)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(\(E2\),)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 28.01000023 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 32.50999832 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 48.78699875 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 53.28699875 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 58.26200104 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 62.76200104 58.52199936 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 101.44300079 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 105.94300079 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 137.25 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 141.75 58.52199936 Tm [(ligase)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 166.54400635 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 171.04400635 58.52199936 Tm [(\(E3\).)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 189.44799805 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 193.94799805 58.52199936 Tm [(UBE1L2)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 226.43699646 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 230.93699646 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 237.4980011 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 241.9980011 58.52199936 Tm [(an)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 252.51899719 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 257.01901245 58.52199936 Tm [(E1)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 267.24499512 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 271.74499512 58.52199936 Tm [(en)-1(z)1(y)-1(m)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 26.82799911 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 31.32799911 74.12200165 Tm [(initiat)1(e)-1(s)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 65.01200104 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 69.51200104 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 83.51300049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 88.01300049 74.12200165 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 129.96299744 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 134.46299744 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 150.74000549 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 155.24000549 74.12200165 Tm [(conj)-1(ug)1(ation)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 206.71800232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 211.21800232 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 220.05999756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 224.55999756 74.12200165 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 281.93099976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 286.43099976 74.12200165 Tm [(pr)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ot)1(e)-1(ins)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 26.28800011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 30.78800011 89.72200012 Tm [(\(Jin)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 45.29899979 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 49.79899979 89.72200012 Tm [(et)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 58.25799942 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 62.75799942 89.72200012 Tm [(al.,)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 74.46099854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 78.96099854 89.72200012 Tm [(20)-1(07)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 100.0719986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 104.5719986 89.72200012 Tm [([PubMed)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 144.03500366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 148.53500366 89.72200012 Tm [(17)-1(59)-1(77)-1(59]\).)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 198.93600464 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 0.75 m 115.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 17.10000038 m 115.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 33.45000076 m 115.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 49.80000305 m 115.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 66.15000153 m 115.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 82.5 m 115.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 98.84999847 m 115.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 115.19999695 m 115.05000305 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 423.17498779 209.17498779 l S Q Q q 1 0 0 1 0 602.4619751 cm /P <</MCID 271 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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