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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.46299744 23.67700005 Tm 0 g [(UACA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.13200378 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.13200378 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.83599854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UA)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.48600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 92.73600006 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.73599243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UA)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.48600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.86000061 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.06199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.43599701 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.41600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.78999329 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.26400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(uveal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.92299652 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.29699707 12.82499981 Tm [(auto)-1(anti)-1(g)1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.05400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.42799377 12.82499981 Tm [(with)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.3769989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.75100708 12.82499981 Tm [(coi)-1(led-coi)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.29899597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.67300415 12.82499981 Tm [(do)-1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.17700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.55099487 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.61401367 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.98800659 12.82499981 Tm [(ankyr)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.64700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.02099609 12.82499981 Tm [(re)1(p)-1(e)1(ats;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.10998535 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.48400879 12.82499981 Tm [(NU)1(CL)-1(IN)1(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.05899048 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(UA)1(CA)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 278.86898804 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(uveal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.74600029 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.24600029 11.72200012 Tm [(auto)1(antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.01899719 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.41500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.91500092 11.72200012 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.72200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.22200012 11.72200012 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.21499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.71499634 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.99200439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.49200439 11.72200012 Tm [(anky)-1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.55400085 11.72200012 Tm [(repeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.44500732 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NUCLING)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.33100128 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(ZF9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.89899826 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(13)-1(40)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 115.42500305 109.94999695 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.27999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.77999878 11.72200012 Tm [(AP)1(AF1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.01000214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51000214 11.72200012 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.46399689 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.96400452 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.24099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.74099731 11.72200012 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.78799438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.28799438 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80900574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.30900574 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.27000427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.77000427 11.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42999268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.92999268 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.8710022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.3710022 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.37200928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.87200928 11.72200012 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(gulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.68799973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.18799973 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.02999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.52999878 27.3220005 Tm [(st)1(re)-1(ss)1(-induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.43800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.93800354 27.3220005 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.09899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.59899902 27.3220005 Tm [(Pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.04400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.54400635 27.3220005 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.53799438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.03799438 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.54998779 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.04998779 27.3220005 Tm [(regul)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.02499962 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.52499962 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.56900024 42.92200089 Tm [(pa)1(thw)1(ays,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.86299896 42.92200089 Tm [(ap)1(opt)1(osome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.55700684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.05700684 42.92200089 Tm [(up-)1(re)-1(g)1(u)-1(la)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.14199829 42.92200089 Tm [(LGA)1(L)-1(S3/galec)-1(t)1(in)-1(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 58.52199936 Tm [(do)1(wn-regulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.03299713 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.53299713 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.80999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.30999756 58.52199936 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.18699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.68699646 58.52199936 Tm [(inac)-1(t)1(ivat)1(i)-1(o)1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.74499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.24499512 58.52199936 Tm [(Regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.5249939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.0249939 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.02600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.52600098 58.52199936 Tm [(redi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(st)1(ribution)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.65999985 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.15999985 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.0019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.5019989 74.12200165 Tm [(AP)1(AF1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.73200226 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.23200226 74.12200165 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.2480011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.7480011 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.74900055 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.24899292 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.06700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.56700134 74.12200165 Tm [(af)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.05799866 74.12200165 Tm [(pro)1(apo)1(pto)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.49299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.99299622 74.12200165 Tm [(st)1(re)-1(ss)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.5539856 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.0539856 74.12200165 Tm [(Do)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(wn-)1(re)-1(g)1(ul)-1(a)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.38600159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.88600159 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.88700104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.38700104 89.72200012 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.34100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84100342 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.68299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18299866 89.72200012 Tm [(LGA)1(L)-1(S3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.91799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.41799927 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.92999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.42999268 89.72200012 Tm [(inhibiting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.50100708 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.00100708 89.72200012 Tm [(NFKB1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.73699951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.23699951 89.72200012 Tm [(\(By)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.6539917 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.1539917 89.72200012 Tm [(si)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(milarit)1(y)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.31800079 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 0.75 m 115.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 17.10000038 m 115.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 33.45000076 m 115.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 49.80000305 m 115.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 66.15000153 m 115.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 82.5 m 115.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 98.84999847 m 115.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 115.19999695 m 115.05000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm
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