%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 71.14099884 23.67700005 Tm 0 g [(TXNDC11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.45500183 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 167.45500183 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 344.15899658 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TXNDC11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.04699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.29699707 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 192.29699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TXNDC11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.04699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.42099762 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.6230011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.99699402 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.977005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.35099792 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.82499695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(thi)-1(ore)1(d)-1(oxi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.39299774 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.76699829 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.16400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.53799438 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.3730011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.74699402 12.82499981 Tm [(11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.19999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.57400513 12.82499981 Tm [(EF)-1(P)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.27200317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(330)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TXNDC11)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 292.20700073 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(th)1(ioredoxin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.53499985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.03499985 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.86199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.36199951 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.10899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.60899353 11.72200012 Tm [(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.16499329 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(EFP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q6PKC3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.13000107 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(13)-1(72)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 129.67500305 78.75 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 297.875 -0.25 l 297.875 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.53199959 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.03199959 11.72200012 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.8730011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.3730011 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.51399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.01399994 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.98899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.48899841 11.72200012 Tm [(redox)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.0719986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.5719986 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.29899597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.79899597 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.16799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.66799927 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.60899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.10899353 11.72200012 Tm [(DU)1(OX)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.82299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.32299805 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.79598999 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.29598999 11.72200012 Tm [(fo)1(l)-1(d)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(g.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.92299986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.42300034 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.22999954 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.72999954 27.3220005 Tm [(interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.06999969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.56999969 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.96600342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.46600342 27.3220005 Tm [(DU)1(OX1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.45799255 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.95799255 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.23500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.73500061 27.3220005 Tm [(DU)1(OX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.727005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.227005 27.3220005 Tm [(sugg)1(e)-1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.07800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.57800293 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.80000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.29998779 27.3220005 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.04800415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.54800415 27.3220005 Tm [(belo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ngs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.46899986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.96899986 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.04400063 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.54399872 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.51900101 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.01900101 42.92200089 Tm [(multipro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.44799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.94799805 42.92200089 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.42700195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.92700195 42.92200089 Tm [(constitut)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57200623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.07200623 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.07299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.57299805 42.92200089 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.54100037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.04100037 42.92200089 Tm [(H2)-1(O2ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ne)-1(r)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.11399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.61399841 58.52199936 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.76899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.26899719 58.52199936 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.26799774 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.76799774 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.32900238 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.82900238 58.52199936 Tm [(ho)1(weve)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.57200623 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.07200623 58.52199936 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.69299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.19299316 58.52199936 Tm [(suff)1(i)-1(cie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.45399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.95399475 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.02900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.52900696 58.52199936 Tm [(assist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.25 58.52199936 Tm [(DU)1(OX1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.24200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.74200439 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 74.12200165 Tm [(DU)1(OX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.29499817 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.23600006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.73600006 74.12200165 Tm [(H2)-1(O2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.58699799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.08699799 74.12200165 Tm [(gene)-1(r)1(ation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.19599915 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 0.75 m 129.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 17.10000038 m 129.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 33.45000076 m 129.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 49.80000305 m 129.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 66.15000153 m 129.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 82.5 m 129.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 98.84999847 m 129.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 115.19999695 m 129.30000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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