%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 112 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.73000336 23.67700005 Tm 0 g [(TXLN)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.86500549 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.86500549 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.56900024 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TXL)-1(N)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.83399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.08399963 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.08399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TXL)-1(N)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.83399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.20800018 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.41000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.78399658 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.76400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.13800049 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.61199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(taxi)-1(li)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.83999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.21399689 12.82499981 Tm [(alp)-1(ha;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.52600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.90000153 12.82499981 Tm [(IL14;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.41299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.78700256 12.82499981 Tm [(TXL)-1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.54600525 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(186-4)1(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(TXL)-1(N)1(A)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 339.66400146 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ta)1(xilin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.62000084 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.12000084 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.75400162 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IL1)-1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.98600006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.48600006 11.72200012 Tm [(TXLN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.38600159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P40)-1(22)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(03)-1(82)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.92500305 16.35000038 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 125.17500305 0.75 l 125.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 126.17500305 -0.25 l 126.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.92500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 125.92500305 78.75 l h f* Q q 1 0 0 1 125.55000305 0 cm -0.625 -0.25 m 301.625 -0.25 l 301.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 5.99399996 11.72200012 Tm [(-t)1(axilin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.50799942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.00799942 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.56900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.06900024 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.04399872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.54399872 11.72200012 Tm [(novel)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.03700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.53700256 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.18099976 11.72200012 Tm [(pa)1(rtner)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.78199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.28199768 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.12399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.62399292 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.625 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.125 11.72200012 Tm [(syntaxin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.43099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.93099976 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.01300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.51300049 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.60998535 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 27.3220005 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.13100052 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.63100052 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.5719986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.0719986 27.3220005 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.53900146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.03900146 27.3220005 Tm [(vesic)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.44500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.94500732 27.3220005 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.62199402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.12199402 27.3220005 Tm [(Throug)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.82499695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.32499695 27.3220005 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.23901367 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.73901367 27.3220005 Tm [(C-t)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(minal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.74399948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24399948 42.92200089 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.0510025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.5510025 42.92200089 Tm [(region,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 112.18000031 42.92200089 Tm [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 118.1740036 42.92200089 Tm [(-t)1(axilin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68800354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.18800354 42.92200089 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.03199768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.53199768 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.92799377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.42799377 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.42900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.92900085 42.92200089 Tm [(nasce)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.13400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.63400269 42.92200089 Tm [(po)1(l)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pept)1(ide-asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.23500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.73500061 58.52199936 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.21399689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.71399689 58.52199936 Tm [(\(NAC\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.06199646 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.15899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.65899658 58.52199936 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.66600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.30700684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.80700684 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.78199768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.28199768 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 74.12200165 Tm [(coactivat)1(or.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.71699905 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 0.75 m 125.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 17.10000038 m 125.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 33.45000076 m 125.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 49.80000305 m 125.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 66.15000153 m 125.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 82.5 m 125.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 98.84999847 m 125.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.55000305 115.19999695 m 125.55000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>