%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.08899689 23.67700005 Tm 0 g [(TULP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.5059967 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.5059967 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.20999146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TULP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.01399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.26399994 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.26400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TULP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.01399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.38800049 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.58999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.96399689 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.94400024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.31799316 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.79200745 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tub)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.81999969 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.19400024 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.01100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.38500214 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.76699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.14100647 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.27200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.64599609 12.82499981 Tm [(CT)-1(6)1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.81399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.18800354 12.82499981 Tm [(TUBL2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TULP2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 281.03601074 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tub)1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.1590004 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6590004 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.45500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.95500183 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26200104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.76200104 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.04000092 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CT6)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.90200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.40200043 11.72200012 Tm [(TUBL2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.82400131 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O00)-1(29)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(26)-1(07)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 132.67500305 78.75 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TULP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.28100014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.78100014 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.34199905 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.84199905 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.81700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.31700134 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.58100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08100128 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.92299652 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.42299652 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.39800262 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.89800262 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.97999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.47999573 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.32200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.82200623 11.72200012 Tm [(tub)1(by-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.67100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.17100525 11.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.85299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.35299683 11.72200012 Tm [(\(TULPs\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.03399658 11.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.32800007 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 27.3220005 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.57799911 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.07799911 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.5510025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.0510025 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.89299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.39299774 27.3220005 Tm [(unk)-1(now)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.30400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.80400085 27.3220005 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.71099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.21099854 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.00100708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.50100708 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.34300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.84300232 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.29901123 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.79901123 27.3220005 Tm [(fa)1(mi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.15899992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.6590004 42.92200089 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00600052 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.50600052 42.92200089 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.01300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.51300049 42.92200089 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.44400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.94400024 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.88500214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.38500214 42.92200089 Tm [(plant)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.73399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.23399353 42.92200089 Tm [(vertebra)1(tes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.91200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.41200256 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.68899536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.18899536 42.92200089 Tm [(inve)-1(r)1(tebrat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.47400093 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.97400093 58.52199936 Tm [(TULP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.97700119 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.47700119 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.94999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.44999695 58.52199936 Tm [(sha)1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.67500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.17500305 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.15000153 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.6499939 58.52199936 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.727005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.227005 58.52199936 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.78100586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.28100586 58.52199936 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.24301147 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.74301147 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.58499146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.08499146 58.52199936 Tm [(ap)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pro)1(ximately)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.88899994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.38899994 74.12200165 Tm [(20)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.22200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.72200012 74.12200165 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.79199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.29199982 74.12200165 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.93199921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.43200684 74.12200165 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27799988 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 0.75 m 132.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 17.10000038 m 132.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 33.45000076 m 132.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 49.80000305 m 132.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 66.15000153 m 132.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 82.5 m 132.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 98.84999847 m 132.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 115.19999695 m 132.30000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>