%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 110 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.11499786 23.67700005 Tm 0 g [(TRPM8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.48100281 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.48100281 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.18499756 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TRPM8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.54100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 98.79100037 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.79100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRPM8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.54100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.91500092 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.11700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.49099731 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.47099304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84500122 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.31900024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transi)-1(e)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.4980011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.8710022 12.82499981 Tm [(re)1(ceptor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.6519928 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.0249939 12.82499981 Tm [(po)-1(te)1(n)-1(tial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.70300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07600403 12.82499981 Tm [(catio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.52600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.89900208 12.82499981 Tm [(chan)-1(nel,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.17199707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.54501343 12.82499981 Tm [(su)-1(bfamil)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.87799072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.25100708 12.82499981 Tm [(M,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.84799194 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.2210083 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.62200928 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 371.99499512 12.82499981 Tm [(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.12600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.49899292 12.82499981 Tm [(TRPP)1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(LT)-1(RP)1(C6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.57699966 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(65-23)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(TRPM8)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 337.42199707 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.87599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.37599945 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.79799652 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.29799652 11.72200012 Tm [(po)1(ten)-1(t)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.89099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.39099884 11.72200012 Tm [(cation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.89399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.39399719 11.72200012 Tm [(channe)-1(l,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.18299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.68299866 11.72200012 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.2250061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.7250061 11.72200012 Tm [(M,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.68499756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.18499756 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.44900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.94900513 11.72200012 Tm [(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.22698975 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TRPP8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.49200058 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.99200058 11.72200012 Tm [(LTRPC6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.44999695 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q7Z2)-1(W)1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.9070015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(13)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 107.17500305 94.34999847 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 320.375 -0.25 l 320.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Transien)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.68299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.18299866 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.60500336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.10500336 11.72200012 Tm [(po)1(ten)-1(t)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.69799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.19799805 11.72200012 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.86099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.36099243 11.72200012 Tm [(channe)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.1499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.6499939 11.72200012 Tm [(\(TRPC\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.2230072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.7230072 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.24099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.74099731 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.71600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.21600342 11.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.29998779 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.79998779 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(six)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74300003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.24300003 27.3220005 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.50299835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.00299835 27.3220005 Tm [(segmen)-1(t)1(-sp)1(anni)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.04299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.54299927 27.3220005 Tm [(ga)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.49099731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.99099731 27.3220005 Tm [(cation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.4940033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.9940033 27.3220005 Tm [(channe)-1(ls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.94900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.44900513 27.3220005 Tm [(TRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.98999023 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.48999023 27.3220005 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ubt)1(y)-1(p)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.43099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.93099976 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55599976 42.92200089 Tm [(st)1(ore-op)1(e)-1(ra)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.43699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.93699646 42.92200089 Tm [(Ca2+)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.88499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.38499451 42.92200089 Tm [(en)-1(t)1(ry,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.75700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.25700378 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.23199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.73199463 42.92200089 Tm [(pro)1(c)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.58999634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.08999634 42.92200089 Tm [(involving)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.29400635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.79400635 42.92200089 Tm [(Ca2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(+)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.67500019 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.17500019 58.52199936 Tm [(influx)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.73799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.23799896 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.51499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.01499939 58.52199936 Tm [(replen)-1(ish)1(me)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.89399719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.39399719 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.23599243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.73599243 58.52199936 Tm [(Ca2+)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.68400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.18400574 58.52199936 Tm [(st)1(ores)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.13400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.63400269 58.52199936 Tm [(fo)1(rme)-1(r)1(l)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.04699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.54699707 58.52199936 Tm [(emptied)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.4460144 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.9460144 58.52199936 Tm [(th)1(roug)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.04299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54299927 74.12200165 Tm [(action)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.04600143 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.54600143 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.38800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.88800049 74.12200165 Tm [(inosito)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.58100128 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.08100128 74.12200165 Tm [(1,4)-1(,)1(5)-1(-)1(trisp)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.39300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.89300537 74.12200165 Tm [(pro)1(duc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.6309967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.1309967 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.4079895 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.9079895 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.06698608 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.56698608 74.12200165 Tm [(Ca)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(2+)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.95300007 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.45299911 89.72200012 Tm [(mob)1(i)-1(liz)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66400146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.16400146 89.72200012 Tm [(ag)1(e)-1(nts)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.23300171 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 0.75 m 106.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 17.10000038 m 106.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 33.45000076 m 106.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 49.80000305 m 106.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 66.15000153 m 106.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 82.5 m 106.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 98.84999847 m 106.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 115.19999695 m 106.80000305 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>