%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 102 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.46099854 23.67700005 Tm 0 g [(TRIM14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.13400269 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 160.13400269 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 336.8380127 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TRIM14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.08399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 101.33399963 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 185.33399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRIM14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.08399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.45800018 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.66000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.03399658 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.01400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.38800049 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.86199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(triparti)-1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46199799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.83599854 12.82499981 Tm [(moti)-1(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.89199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.26600647 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.10099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.4750061 12.82499981 Tm [(14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.1190033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TRIM14)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 286.23901367 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 141.9750061 16.35000038 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(i)-1(p)1(art)1(ite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.55099869 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.05099869 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.0739975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.5739975 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.32099915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.82099915 11.72200012 Tm [(14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3769989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 141.9750061 16.35000038 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q14)-1(14)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 141.9750061 16.35000038 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(06)-1(33)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 141.9750061 16.35000038 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 141.9750061 16.35000038 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 141.9750061 16.35000038 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 141.2250061 0.75 l 141.2250061 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 142.2250061 -0.25 l 142.2250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.9750061 0.75 m 426.17501831 0.75 l 426.17501831 94.34999847 l 141.9750061 94.34999847 l h f* Q q 1 0 0 1 141.6000061 0 cm -0.625 -0.25 m 285.57501221 -0.25 l 285.57501221 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(tr)1(i)-1(p)1(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tit)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.20800018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.70800018 27.3220005 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.73099899 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.23099899 27.3220005 Tm [(\(TRIM\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.71600342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.21600342 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.46399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.96399689 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.77100372 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.27099609 27.3220005 Tm [(TRIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.74499512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.24499512 27.3220005 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26800537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.76800537 27.3220005 Tm [(inc)-1(ludes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.19200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.69200134 27.3220005 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.23599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.73599243 27.3220005 Tm [(zinc-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.14400101 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.64400101 42.92200089 Tm [(do)1(mains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.80400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.30400085 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.27899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.77899933 42.92200089 Tm [(RING)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.47599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97599792 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.9509964 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.45100403 42.92200089 Tm [(B-bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.022995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.522995 42.92200089 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.4940033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.9940033 42.92200089 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.27200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.77200317 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.04899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.54899597 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.52400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.02400208 42.92200089 Tm [(B-bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.59599304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.09599304 42.92200089 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.06698608 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.44399977 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.94400024 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.22100067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.72100067 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.69599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.19599915 58.52199936 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.00299835 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.50299835 58.52199936 Tm [(region.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.63200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.13200378 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.93899536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.43899536 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.7460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.2460022 58.52199936 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.33799744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.83799744 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.91299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.41299438 58.52199936 Tm [(cy)-1(t)1(oplas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.3409996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.8409996 74.12200165 Tm [(bo)1(die)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.73500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.23500061 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.51200104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.01200104 74.12200165 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.9260025 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.4260025 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.16699982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.66700745 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.34899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.84899902 74.12200165 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.47000122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.97000122 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.477005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.977005 74.12200165 Tm [(determine)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.13999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.63999939 74.12200165 Tm [(Alt)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(at)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.5529995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.0529995 89.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.9679985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.4679985 89.72200012 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.63700104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.13700104 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.07800293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.57800293 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.94999695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.44999695 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.37199402 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.87199402 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.60800171 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 0.75 m 141.6000061 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 17.10000038 m 141.6000061 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 33.45000076 m 141.6000061 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 49.80000305 m 141.6000061 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 66.15000153 m 141.6000061 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 82.5 m 141.6000061 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.6000061 98.84999847 m 141.6000061 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 192.82499695 m 426.92501831 192.82499695 l S Q Q q 1 0 0 1 0 576.32897949 cm Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>