%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.90200043 23.67700005 Tm 0 g [(TRAK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.69299316 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.69299316 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.39700317 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TRAK)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.91999817 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.91999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRAK)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.04399872 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.2460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.61999512 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.6000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.97399902 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.44799805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(traffickin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.10700226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.48100281 12.82499981 Tm [(protein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.48300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.85699463 12.82499981 Tm [(kinesi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.81399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.18800354 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.01600647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.38999939 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.52099609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.89500427 12.82499981 Tm [(MILT)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.17999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.55400085 12.82499981 Tm [(OIP10)1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.54098511 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TRAK)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 281.59799194 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(aff)1(i)-1(cki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.50999832 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.00999832 11.72200012 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.48300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.98300171 11.72200012 Tm [(ki)-1(nesin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.03700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.53700256 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.18099976 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.45899963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MILT1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.6609993 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.1609993 11.72200012 Tm [(OIP10)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.48100281 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UPV9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.20199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(92)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 47.54999924 l 131.375 47.54999924 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.61999893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.11999893 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06100082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.56100082 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.56199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.06199646 11.72200012 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.29299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.79299927 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63499451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.13499451 11.72200012 Tm [(en)-1(d)1(osome-t)1(o-lysos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.02900696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.52900696 11.72200012 Tm [(tr)1(aff)1(i)-1(cki)-1(ng)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.20599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.84999847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.34999847 27.3220005 Tm [(en)-1(d)1(ocy)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.01899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.51899719 27.3220005 Tm [(tr)1(aff)1(i)-1(cki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.02900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.52900696 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.3710022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.8710022 27.3220005 Tm [(EG)1(F)-1(-)1(EGFR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.48500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.98500061 27.3220005 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.73599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.23599243 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.51300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.01300049 27.3220005 Tm [(GA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(BA-A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.20599937 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.70599937 42.92200089 Tm [(rec)-1(ept)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.45999908 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 0.75 m 131 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 17.10000038 m 131 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 33.45000076 m 131 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 49.80000305 m 131 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 66.15000153 m 131 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 82.5 m 131 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 98.84999847 m 131 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 115.19999695 m 131 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 426.92498779 162.375 l S Q Q q 1 0 0 1 0 545.87902832 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>