%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.86299896 23.67700005 Tm 0 g [(TPX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73199463 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.73199463 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 324.43600464 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TPX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.31300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.56300354 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.56300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TPX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.31300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.68699646 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.88899994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.26300049 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.24299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.61700439 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.09100342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TPX2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.93299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.62400055 12.82499981 Tm [(microtub)-1(ul)-1(e)1(-as)-1(sociated;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.70100403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.39199829 12.82499981 Tm [(DIL)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.04299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.73399353 12.82499981 Tm [(p100;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.02600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.7170105 12.82499981 Tm [(DIL)-1(-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.58300781 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.27398682 12.82499981 Tm [(HCT)-1(P)1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.08700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.77801514 12.82499981 Tm [(FL)-1(S353;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 370.61599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.30700684 12.82499981 Tm [(HCA519)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(REPP)1(86;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.13000107 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.50400162 30.49699783 Tm [(C20orf1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.27999878 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.65399933 30.49699783 Tm [(C20orf2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.43000031 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.80400085 30.49699783 Tm [(GD:C20orf1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66400146 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TPX2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 276.14898682 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TPX2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.91500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.41500092 11.72200012 Tm [(mic)-1(r)1(otubule-ass)1(oc)-1(iat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63000488 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 137.92500305 31.95000076 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DIL2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.56399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.06399918 11.72200012 Tm [(p10)-1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.81200027 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.31200027 11.72200012 Tm [(DIL-)1(2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.76999664 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.26999664 11.72200012 Tm [(HCT)-1(P)1(4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.36100006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.86100006 11.72200012 Tm [(FLS)-1(353)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.45500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.95500183 11.72200012 Tm [(HCA51)-1(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.26899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.76899719 11.72200012 Tm [(REP)1(P8)-1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.82800293 11.72200012 Tm [(C20)-1(or)1(f1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.12701416 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(C20)-1(or)1(f2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29899979 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.79899979 27.3220005 Tm [(GD)1(:C20)-1(or)1(f1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.64600372 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9ULW0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.38600159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(04)-1(13)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 137.92500305 78.75 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TPX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.74900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.24900055 11.72200012 Tm [(\(ta)1(rgeting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.93299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.43299866 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.73999786 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.23999786 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.51799774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.01799774 11.72200012 Tm [(Xkl)-1(p)1(2)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.1499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.6499939 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.21099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.71099854 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.68600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.18600464 11.72200012 Tm [(mic)-1(r)1(otubule-ass)1(oc)-1(iat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.40100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.1760025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.6760025 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.61699677 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.11699677 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.29499817 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.29600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.79600525 27.3220005 Tm [(mot)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.46200562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.96200562 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.26899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.76899719 27.3220005 Tm [(Xkl)-1(p)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.89500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.39500427 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.47000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.97000122 27.3220005 Tm [(mic)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(u)-1(b)1(ul)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.74900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.24900055 42.92200089 Tm [(Ran-)1(GTP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.89700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.39700317 42.92200089 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.95700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.45700073 42.92200089 Tm [(TPX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.20599365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.70599365 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.98399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.48399353 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.48500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.98500061 42.92200089 Tm [(chromat)1(in-induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.41299438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mic)-1(r)1(obutule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.19400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.69400024 58.52199936 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.4469986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.9469986 58.52199936 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.38400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.88400269 58.52199936 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.67700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.17700195 58.52199936 Tm [(ph)1(ase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.88000488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.38000488 58.52199936 Tm [(Auro)1(ra-A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.05400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.55400085 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.64199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.14199829 58.52199936 Tm [(asso)1(c)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.60000038 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.10000038 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.49599838 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.99599838 74.12200165 Tm [(TPX2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.74500275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.24500275 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.57299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.07299805 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.0739975 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.5739975 74.12200165 Tm [(spindle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.68699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.18699646 74.12200165 Tm [(ap)1(para)1(tus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.10800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.60800171 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.88499451 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.38499451 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.55599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.05599976 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.73098755 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.23098755 74.12200165 Tm [(TP)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 0.75 m 137.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 17.10000038 m 137.55000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 49.05000305 m 137.55000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 65.40000153 m 137.55000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 81.75 m 137.55000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 98.09999847 m 137.55000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 114.44999695 m 137.55000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 130.80000305 m 137.55000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>