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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.09700012 23.67700005 Tm 0 g [(TP53)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 144.49899292 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 321.20300293 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TP53)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 84.18499756 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.43499756 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.43499756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 178.68499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TP53)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 84.18499756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 86.55899811 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 119.76100159 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 122.13500214 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 182.11500549 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 184.48899841 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 218.96299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130014000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <</MCID 34 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 240.09500122 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 38 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-233)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(TP53)] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 324.83999634 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 269.03399658 m 416.75 269.03399658 l 416.75 300.23400879 l -1.45000005 300.23400879 l h f* Q q 1 0 0 1 0 269.03399658 cm /P <</MCID 66 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 300.23400879 m 416.75 300.23400879 l 416.75 331.434021 l -1.45000005 331.434021 l h f* Q q 1 0 0 1 0 300.23400879 cm /P <</MCID 67 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 331.43399048 cm /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 359.37298584 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 71 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tumor)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 26.48999977 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 30.98999977 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 62.29700089 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 66.79699707 11.72200012 Tm [(p53)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 83.10099792 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P53)-1(;)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 18.22900009 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 22.72900009 11.72200012 Tm [(BCC7)-1(;)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 47.86100006 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 52.36100006 11.72200012 Tm [(LFS)-1(1;)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 74.40000153 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 78.90000153 11.72200012 Tm [(TRP53)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 105.99700165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P04)-1(63)-1(7)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(03)-1(59)-1(6)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 102 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 122 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 128 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 129 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 141 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 142 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 124.42500305 141.1499939 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 143 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(tumor)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 124.16000366 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 128.66000366 11.72200012 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 175.90100098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 180.40100098 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 211.70799255 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 216.20799255 11.72200012 Tm [(containing)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 261.95498657 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 266.45498657 11.72200012 Tm [(tr)1(ans)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(criptiona)1(l)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 40.47800064 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 44.97800064 27.3220005 Tm [(activat)1(ion,)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 89.09500122 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 93.59500122 27.3220005 Tm [(DNA)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 114.09999847 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 118.59999847 27.3220005 Tm [(binding,)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 153.91000366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 158.41000366 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 174.68699646 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 179.18699646 27.3220005 Tm [(oligo)1(me)-1(riz)1(ation)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 246.96400452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 251.46400452 27.3220005 Tm [(do)1(mains.)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 290.62399292 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 15.80700016 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 20.30699921 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 57.81399918 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 62.31399918 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 93.6210022 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 98.1210022 42.92200089 Tm [(respond)1(s)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 137.76800537 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 142.26800537 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 151.34300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 155.84300232 42.92200089 Tm [(diverse)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 186.53399658 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 191.03399658 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 221.79600525 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 226.29600525 42.92200089 Tm [(st)1(re)-1(ss)1(e)-1(s)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 259.9630127 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 264.4630127 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 273.53799438 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 278.03799438 42.92200089 Tm [(re)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gulat)1(e)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 27.13199997 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 31.63199997 58.52199936 Tm [(expression)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 77.58599854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 82.08599854 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 90.9280014 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 95.4280014 58.52199936 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 121.40799713 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 125.90799713 58.52199936 Tm [(gene)-1(s,)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 153.7559967 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 158.2559967 58.52199936 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 191.31199646 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 195.81199646 58.52199936 Tm [(induc)-1(ing)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 233.26699829 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 237.76699829 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 252.17700195 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 256.67700195 58.52199936 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 277.96899414 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 282.46899414 58.52199936 Tm [(ar)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rest,)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 18.22900009 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 22.72900009 74.12200165 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 66.88999939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 71.38999939 74.12200165 Tm [(sene)-1(sce)-1(nce)-1(,)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 122.43199921 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 126.93199921 74.12200165 Tm [(DNA)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 147.43699646 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 151.93699646 74.12200165 Tm [(repair,)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 179.20100403 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 183.70100403 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 192.85899353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 197.35899353 74.12200165 Tm [(changes)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 232.96299744 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 237.46299744 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 245.40400696 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 249.90400696 74.12200165 Tm [(metab)1(oli)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(sm.)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 14.76599979 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 19.26600075 89.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 63.11500168 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 67.61499786 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 75.55599976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 80.05599976 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 95.51200104 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 100.01200104 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 121.52799988 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 126.02799988 89.72200012 Tm [(are)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 139.54600525 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 144.04600525 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 189.17300415 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 193.67300415 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 212.06900024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 216.56900024 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 221.54400635 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 226.04400635 89.72200012 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 254.79699707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 259.29699707 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 268.13900757 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 272.63900757 89.72200012 Tm [(hu)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(man)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 18.95400047 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 23.45400047 105.3219986 Tm [(canc)-1(ers,)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 57.87599945 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 62.37599945 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 102.22599792 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 106.72599792 105.3219986 Tm [(heredita)1(ry)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 150.59700012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 155.09700012 105.3219986 Tm [(canc)-1(ers)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 187.35299683 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 191.85299683 105.3219986 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 211.61999512 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 216.11999512 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 225.26100159 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 229.76100159 105.3219986 Tm [(Li-Fraumen)-1(i)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 280.88699341 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 285.38699341 105.3219986 Tm [(s)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(yn)-1(d)1(rome.)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 40.93099976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 45.43099976 120.92199707 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 92.15399933 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 96.65399933 120.92199707 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 129.56900024 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 134.06900024 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 142.91099548 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 147.41099548 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 162.86700439 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 167.36700439 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 188.88299561 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 193.38299561 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 209.66000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 214.16000366 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 228.16099548 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 232.66099548 120.92199707 Tm [(use)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 247.47900391 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 251.97900391 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 260.8210144 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 265.3210144 120.92199707 Tm [(alt)1(e)-1(rn)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(at)1(e)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 13.43400002 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 17.93400002 136.52200317 Tm [(pro)1(moters)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 63.05699921 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 67.55699921 136.52200317 Tm [(result)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 91.55999756 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 96.05999756 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 104.00099945 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 108.50099945 136.52200317 Tm [(multiple)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 143.8730011 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 148.3730011 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 189.29499817 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 193.79499817 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 227.36500549 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 231.86500549 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 248.14199829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 252.64199829 136.52200317 Tm [(isof)1(orms)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 0.75 m 124.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 17.10000038 m 124.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 33.45000076 m 124.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 49.80000305 m 124.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 66.15000153 m 124.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 82.5 m 124.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 98.84999847 m 124.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 115.19999695 m 124.05000305 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 255.97497559 m 423.17498779 255.97497559 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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