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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 75.02899933 23.67700005 Tm 0 g [(TNFAI)1(P)-1(3)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 152.56599426 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.56599426 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.26998901 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TNFAIP)1(3)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 99.18599701 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 104.43599701 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.43600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNFAIP)1(3)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 99.18599701 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 101.55999756 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 134.76199341 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 137.13600159 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 197.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 199.49000549 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 233.96400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNF)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 79.71900177 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 82.09300232 12.82499981 Tm [(alp)-1(ha)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 105.59500122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 107.96900177 12.82499981 Tm [(in)-1(du)-1(ce)1(d)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 142.10899353 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 144.48300171 12.82499981 Tm [(protein)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 175.86500549 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 178.23899841 12.82499981 Tm [(3;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 186.36999512 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 188.7440033 12.82499981 Tm [(A2)1(0;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 208.272995 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 210.64700317 12.82499981 Tm [(AISBL;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 237.12800598 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 239.5019989 12.82499981 Tm [(OTUD7C;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 278.49798584 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 280.87200928 12.82499981 Tm [(TNFA1P)1(2)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 319.73400879 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 57 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 270.37298584 cm /P <</MCID 58 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(580-7)1(90)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(TNFAIP)1(3)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 346.82299805 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 298.31201172 cm /P <</MCID 86 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 326.25100708 cm /P <</Lang (zh-CN) /MCID 87 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 354.19000244 cm /P <</MCID 89 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 382.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TNF)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 17.25699997 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 21.75699997 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 45.39099884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 49.89099884 11.72200012 Tm [(induc)-1(ed)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 84.51100159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 89.01100159 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 120.31800079 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 124.81800079 11.72200012 Tm [(3)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 130.09599304 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 104 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 105 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(A20;)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 19.05500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 23.55500031 11.72200012 Tm [(AISBL;)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 50.1590004 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 54.6590004 11.72200012 Tm [(OTUD)1(7)-1(C;)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 94.19200134 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 98.69200134 11.72200012 Tm [(TNFA1)-1(P)1(2)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 138.34399414 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 114 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 115 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 116 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P21)-1(58)-1(0)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 118 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 121 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 122 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(14)-1(48)-1(0)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 124 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 125 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 126 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 142 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 145 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 146 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 151 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.92500305 16.35000038 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 152 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 131.17500305 0.75 l 131.17500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 132.17500305 -0.25 l 132.17500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 164 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 165 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.92500305 0.75 m 426.17498779 0.75 l 426.17498779 125.55000305 l 131.92500305 125.55000305 l h f* Q q 1 0 0 1 131.55000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 166 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 64.02500153 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 68.52500153 11.72200012 Tm [(identified)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 109.45600128 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 113.95600128 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 123.09700012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 127.59700012 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 132.57200623 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 137.07200623 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 158.58799744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 163.08799744 11.72200012 Tm [(wh)1(ose)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 190.72999573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 195.22999573 11.72200012 Tm [(expression)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 241.18400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 245.68400574 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 252.24499512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 256.74499512 11.72200012 Tm [(rap)1(idly)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 286.21499634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(induc)-1(ed)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 34.61999893 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 39.11999893 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 49.63199997 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 54.13199997 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 68.13300323 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 72.63300323 27.3220005 Tm [(tumor)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 99.1230011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 103.6230011 27.3220005 Tm [(ne)-1(crosis)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 138.67399597 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 143.17399597 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 168.29299927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 172.79299927 27.3220005 Tm [(\(TNF\).)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 198.22900391 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 202.72900391 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 218.53599548 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 223.03599548 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 254.34300232 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 258.84298706 27.3220005 Tm [(en)-1(cod)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ed)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 10.86299992 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 15.36299992 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 25.875 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 30.375 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 45.83100128 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 50.33100128 42.92200089 Tm [(gene)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 71.84700012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 76.34700012 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 82.90799713 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 87.40799713 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 92.38300323 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 96.88300323 42.92200089 Tm [(zinc)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 113.76200104 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 118.26200104 42.92200089 Tm [(finger)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 143.6230011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 148.1230011 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 179.42999268 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 183.92999268 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 200.20700073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 204.70700073 42.92200089 Tm [(ubiqit)1(in)-1(-)1(e)-1(d)1(iting)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 272.04400635 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 276.54400635 42.92200089 Tm [(en)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(zyme,)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 24.89500046 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 29.39500046 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 45.67200089 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 50.17200089 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 64.85399628 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 69.35399628 58.52199936 Tm [(been)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 90.86100006 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 95.36100006 58.52199936 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 123.44200134 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 127.94200134 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 137.01699829 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 141.51699829 58.52199936 Tm [(inhibit)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 168.89100647 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 173.39100647 58.52199936 Tm [(NF-kapp)1(a)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 215.72799683 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 220.22799683 58.52199936 Tm [(B)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 225.875 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 230.375 58.52199936 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 272.32501221 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 276.82501221 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 285.96600342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(well)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 17.00200081 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 21.50200081 74.12200165 Tm [(as)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 30.64299965 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 35.14300156 74.12200165 Tm [(TNF-mediated)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 97.1760025 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 101.6760025 74.12200165 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 145.83700562 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 150.33700562 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 166.14399719 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 170.64399719 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 208.15100098 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 212.65100098 74.12200165 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 246.12399292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 250.62399292 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 275.7210083 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 280.2210083 74.12200165 Tm [(h)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 9.14099979 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 13.64099979 89.72200012 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 34.00500107 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 38.50500107 89.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 77.18599701 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 81.68599701 89.72200012 Tm [(ligase)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 106.48000336 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 110.98000336 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 127.25700378 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 131.75700378 89.72200012 Tm [(deubiquitinase)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 195.54800415 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 200.04800415 89.72200012 Tm [(activit)1(i)-1(es,)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 239.58999634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 244.08999634 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 250.65100098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 255.15100098 89.72200012 Tm [(involve)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(d)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 18.19799995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 22.69799995 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 36.69900131 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 41.19900131 105.3219986 Tm [(cy)-1(t)1(oki)-1(ne-mediat)1(e)-1(d)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 122.27400208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 126.77400208 105.3219986 Tm [(immun)-1(e)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 162.23300171 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 166.73300171 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 183.00999451 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 187.50999451 105.3219986 Tm [(inflammat)1(ory)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 245.05599976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 249.55599976 105.3219986 Tm [(respons)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(es.)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 11.43900013 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 15.93900013 120.92199707 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 46.8769989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 51.3769989 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 92.2990036 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 96.7990036 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 130.3690033 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 134.8690033 120.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 175.21099854 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 179.71099854 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 193.71200562 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 198.21200562 120.92199707 Tm [(same)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 220.89199829 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 225.39199829 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 256.69900513 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 261.19900513 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 281.54598999 120.92199707 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 0.75 m 131.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 17.10000038 m 131.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 33.45000076 m 131.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 49.80000305 m 131.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 66.15000153 m 131.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 82.5 m 131.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 98.84999847 m 131.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.55000305 115.19999695 m 131.55000305 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 426.92498779 240.375 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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