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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n q 1 0 0 1 0 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAAAI 22 Tf 1 0 0 -1 58.47499847 23.67700005 Tm 0 g [(TMPRSS11)1(A)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 169.11999512 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 180.11999512 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAAAI 22 Tf 1 0 0 -1 356.82400513 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TMPRSS)-1(11)1(A)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 114.58699799 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 119.83699799 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 203.83700562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TMPRSS)-1(11)1(A)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 114.58699799 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 116.96099854 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 150.16299438 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 152.53700256 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 212.51699829 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 214.89100647 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 249.36500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transme)1(mb)-1(r)1(an)-1(e)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 131.77799988 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 134.1519928 12.82499981 Tm [(protease,)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 174.58799744 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 176.96200562 12.82499981 Tm [(ser)1(i)-1(ne)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 203.10400391 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 205.47799683 12.82499981 Tm [(11A)1(;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 225.00700378 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 227.3809967 12.82499981 Tm [(ECRG1)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 255.7539978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 49 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 47.37799835 l -0.75 47.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 50 >> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 34.38800049 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 65.76999664 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 72.24700165 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 133.83200073 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 140.30900574 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 149.36300659 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 155.83999634 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 160.86999512 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 167.34700012 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 194.63800049 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 201.11500549 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 233.41000366 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 239.88699341 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 260.67700195 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 267.1539917 12.55799961 Tm [(203-35)1(3)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 302.29901123 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 308.77600098 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 335.65701294 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 342.13400269 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 363.63598633 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 370.11300659 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 378.85400391 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 385.33099365 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 415.29800415 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(TMPRSS)-1(11)1(A)] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 51.5870018 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 46.37799835 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 46.37799835 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 46.62799835 m 426.3500061 46.62799835 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <</MCID 78 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <</MCID 81 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 86 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 68.26000214 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 72.76000214 11.72200012 Tm [(pro)1(tease,)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 112.53900146 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 117.03900146 11.72200012 Tm [(serine)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 142.79499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 147.29499817 11.72200012 Tm [(11)-1(A)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 164.18299866 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ECRG)1(1)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 28.81500053 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q6ZM)-1(R)1(5)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 38.13999939 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 105 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(11)-1(79)-1(6)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 109 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 126 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 129 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 134 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 135 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 134.92500305 16.35000038 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 136 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 134.17500305 0.75 l 134.17500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 135.17500305 -0.25 l 135.17500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 148 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 149 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.92500305 0.75 m 426.17498779 0.75 l 426.17498779 47.54999924 l 134.92500305 47.54999924 l h f* Q q 1 0 0 1 134.55000305 0 cm -0.625 -0.25 m 292.625 -0.25 l 292.625 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pro)1(bab)1(l)-1(e)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 38.63700104 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 43.13700104 11.72200012 Tm [(serine)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 68.89299774 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 73.39299774 11.72200012 Tm [(pro)1(tease)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 111.0059967 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 115.5059967 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 140.60299683 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 145.10299683 11.72200012 Tm [(may)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 163.27400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 167.77400208 11.72200012 Tm [(play)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 185.65499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 190.15499878 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 195.13000488 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 199.63000488 11.72200012 Tm [(role)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 216.28999329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 220.78999329 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 228.73100281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 233.23100281 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 263.99301147 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 268.49301147 11.72200012 Tm [(sen)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(esc)-1(enc)-1(e.)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 36.22399902 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 40.72399902 27.3220005 Tm [(Overexpression)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 107.27899933 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 111.77899933 27.3220005 Tm [(inhibits)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 143.31900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 147.81900024 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 162.22900391 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 166.72900391 27.3220005 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 197.64500427 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 202.14500427 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 218.42199707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 222.92199707 27.3220005 Tm [(induc)-1(e)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 251.78500366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 256.28500366 27.3220005 Tm [(G1)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 268.25601196 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 272.75601196 27.3220005 Tm [(ce)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ll)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 4.78999996 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 9.28999996 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 30.58200073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 35.08200073 42.92200089 Tm [(arr)1(e)-1(st)1(.)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 61.72200012 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 0.75 m 134.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 17.10000038 m 134.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 33.45000076 m 134.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 49.80000305 m 134.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 66.15000153 m 134.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 82.5 m 134.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 98.84999847 m 134.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.55000305 115.19999695 m 134.55000305 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 426.92498779 162.375 l S Q Q q 1 0 0 1 0 563.81799316 cm Q Q 1 0 0 -1 0 841.90002441 cm 
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