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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 77.6989975 23.67700005 Tm 0 g [(TMEFF1)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 149.89700317 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 160.89700317 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 337.60101318 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TME)-1(FF)-1(1)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 97.19200134 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.44200134 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.44200134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TME)-1(FF)-1(1)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 97.19200134 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 99.56600189 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 132.76800537 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 135.14199829 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 195.12199402 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 197.4960022 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 231.97000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transme)1(mb)-1(r)1(an)-1(e)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 131.77799988 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 136.09500122 12.82499981 Tm [(protein)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 167.477005 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 171.79400635 12.82499981 Tm [(with)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 190.74299622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 195.05999756 12.82499981 Tm [(EGF)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 211.63499451 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 215.95199585 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 230.76899719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 235.08599854 12.82499981 Tm [(and)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 251.14900208 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 255.46600342 12.82499981 Tm [(two)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 272.02600098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 276.34298706 12.82499981 Tm [(fo)-1(lli)-1(stati)-1(n)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 316.41000366 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 320.72698975 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 335.54400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 339.86099243 12.82499981 Tm [(do)-1(mains)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 376.36499023 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 380.68200684 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 388.81298828 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 393.13000488 12.82499981 Tm [(TR-1;)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 415.29400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(H7365)1(;)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 30.63899994 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 33.01300049 30.49699783 Tm [(C9orf2;)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 64.46700287 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 66.84100342 30.49699783 Tm [(CT)-1(1)1(20.1)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 101.4940033 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <</MCID 69 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 70 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(51-25)1(0)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(TME)-1(FF)-1(1)] TJ ET EMC /P <</MCID 97 >> BDC BT /FAAABB 9 Tf 1 0 0 -1 340.55099487 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <</MCID 98 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <</Lang (zh-CN) /MCID 99 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <</MCID 101 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <</MCID 105 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 143.17500305 31.95000076 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 68.26000214 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 72.76000214 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 104.06700134 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 108.56700134 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 126.96299744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 131.46299744 11.72200012 Tm [(EG)1(F)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 147.88499451 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 152.38499451 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 167.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 171.68099976 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 187.95799255 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 192.45799255 11.72200012 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 208.63900757 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 213.13900757 11.72200012 Tm [(fo)1(l)-1(list)1(atin)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 252.95300293 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 257.45300293 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 272.24899292 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(do)1(mains)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 36.99300003 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 41.49300003 27.3220005 Tm [(1)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 46.77099991 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 128 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 129 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TR-1;)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 22.37299919 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 26.87299919 11.72200012 Tm [(H7)-1(36)-1(5;)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 57.11199951 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 61.61199951 11.72200012 Tm [(C9orf2;)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 92.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 97.13300323 11.72200012 Tm [(CT1)-1(20.1)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 131.59100342 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 138 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 139 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 140 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8IYR6)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 31.84300041 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 142 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 145 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 146 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(35)-1(05)-1(6)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 148 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 149 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 166 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 169 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 170 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 174 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 175 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 176 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 188 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 189 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 426.17498779 0.75 l 426.17498779 47.54999924 l 143.17500305 47.54999924 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 190 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(May)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 18.53199959 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 23.03199959 11.72200012 Tm [(inhibit)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 50.40599823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 54.90599823 11.72200012 Tm [(NODA)1(L)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 87.36399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 91.86399841 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 108.14099884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 112.64099884 11.72200012 Tm [(BMP)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 132.58799744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 137.08799744 11.72200012 Tm [(signaling)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 176.01899719 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 180.51899719 11.72200012 Tm [(during)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 208.95599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 213.45599365 11.72200012 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 240.46000671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 244.96000671 11.72200012 Tm [(pa)1(tter)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nin)-1(g)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 19.24399948 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 23.74399948 27.3220005 Tm [(\(By)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 37.1609993 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 41.6609993 27.3220005 Tm [(similarit)1(y)-1(\).)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 85.54000092 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 90.04000092 27.3220005 Tm [(May)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 108.5719986 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 113.0719986 27.3220005 Tm [(be)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 123.9260025 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 128.42599487 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 133.40100098 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 137.90100098 27.3220005 Tm [(tumor)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 164.39100647 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 168.89100647 27.3220005 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 216.13200378 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 220.63200378 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 228.57299805 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 233.07299805 27.3220005 Tm [(bra)1(in)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 255.17300415 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 259.67300415 27.3220005 Tm [(can)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ce)-1(rs.)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 19.38899994 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 32.70000076 m 142.80000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 49.05000305 m 142.80000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 65.40000153 m 142.80000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 81.75 m 142.80000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 98.09999847 m 142.80000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 114.44999695 m 142.80000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 130.80000305 m 142.80000305 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 579.41802979 cm Q Q 1 0 0 -1 0 841.90002441 cm 
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