%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.86199951 23.67700005 Tm 0 g [(TMED4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.73300171 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.73300171 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.43701172 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TME)-1(D4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.00299835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.25299835 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.25300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TME)-1(D4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.00299835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.3769989 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.57899475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.95300293 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.30700684 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.78100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transme)1(mb)-1(r)1(an)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.77799988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.08599854 12.82499981 Tm [(em)1(p)-1(24)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.16600037 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.54800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.85600281 12.82499981 Tm [(transpo)-1(r)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.91799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.22599792 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.62298584 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.93099976 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.76599121 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 342.07400513 12.82499981 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 350.20498657 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.51300049 12.82499981 Tm [(HNLF;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.88101196 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 386.18899536 12.82499981 Tm [(ERS)-1(25)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29501343 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(GMP)1(25i)-1(so;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.5320015 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.90599823 30.49699783 Tm [(p24al)-1(pha3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.88999939 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(198)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TME)-1(D4)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 284.45498657 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 146.92500305 31.95000076 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.26000214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.76000214 11.72200012 Tm [(emp24)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.60299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.10299683 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.41000366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.91000366 11.72200012 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.64500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.14500427 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.47200012 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.21899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HNL)-1(F;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.84399986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.34399986 11.72200012 Tm [(ERS25)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.08399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.58399963 11.72200012 Tm [(GMP25iso;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.58200073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.08200073 11.72200012 Tm [(p24)-1(a)1(lpha)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.29699707 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q7Z7)-1(H5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.70999908 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(57)-1(85)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 146.92500305 78.75 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.61999893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.11999893 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06100082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.56100082 11.72200012 Tm [(vesic)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.81800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.31800079 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.625 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.125 11.72200012 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.80200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.30200195 11.72200012 Tm [(mainly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.80900574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.30900574 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.25 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.75 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.75100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.25100708 11.72200012 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(sec)-1(reto)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.60400009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.10400009 27.3220005 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.73200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.23200226 27.3220005 Tm [(ta)1(rgeting.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.07699585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.57699585 27.3220005 Tm [(Involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.19700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.69700623 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.63800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.13800049 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.63900757 27.3220005 Tm [(maintenanc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.13299561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.63299561 27.3220005 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.62100029 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.12100029 42.92200089 Tm [(Go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.58200073 42.92200089 Tm [(ap)1(para)1(tus.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.66999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.16999817 42.92200089 Tm [(Ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.68200684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.25700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75700378 42.92200089 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.63800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.13800049 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.11300659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.61300659 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.272995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.772995 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.71400452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.21400452 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.71499634 42.92200089 Tm [(bios)1(y)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(hesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.71699905 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.21699905 58.52199936 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.76200104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26200104 58.52199936 Tm [(cargo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16500092 58.52199936 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.01499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.51499939 58.52199936 Tm [(pro)1(c)-1(essing.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.23699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.73699951 58.52199936 Tm [(Involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.35699463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.85699463 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.79800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.29800415 58.52199936 Tm [(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(do)1(plasmic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.10400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.60400009 74.12200165 Tm [(reticu)-1(lum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.32800293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.82800293 74.12200165 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.22200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.72200012 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.88600159 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.38600159 74.12200165 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.91799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.41799927 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.29899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.79899597 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.77400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.27400208 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.93400574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.43400574 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.375 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.875 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.87600708 74.12200165 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 0.75 m 146.55000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 32.70000076 m 146.55000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 49.05000305 m 146.55000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 65.40000153 m 146.55000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 81.75 m 146.55000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 98.09999847 m 146.55000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 114.44999695 m 146.55000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 130.80000305 m 146.55000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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