%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.86199951 23.67700005 Tm 0 g [(TMED3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.73300171 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.73300171 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.43701172 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TME)-1(D3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.00299835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.25299835 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.25300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TME)-1(D3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.00299835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.3769989 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.57899475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.95300293 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.30700684 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.78100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transme)1(mb)-1(r)1(an)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.77799988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.45100403 12.82499981 Tm [(em)1(p)-1(24)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.2230072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.89599609 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.27799988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.95100403 12.82499981 Tm [(transpo)-1(r)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.01300049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.68600464 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.08300781 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.75601196 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 343.59100342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 350.26400757 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 358.39498901 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.06799316 12.82499981 Tm [(p26;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.03799438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.71099854 12.82499981 Tm [(P2)1(4B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(C15orf22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.2879982 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(194)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TME)-1(D3)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 284.45498657 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.26000214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.76000214 11.72200012 Tm [(emp24)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.60299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.10299683 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.41000366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.91000366 11.72200012 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.64500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.14500427 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.47200012 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.21899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.71899414 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.99700928 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(p26)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.46999931 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.96999931 11.72200012 Tm [(P24)-1(B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.84500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.34500122 11.72200012 Tm [(C15)-1(or)1(f22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.75499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y3Q3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.93399811 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(02)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 426.17498779 0.75 l 426.17498779 47.54999924 l 125.17500305 47.54999924 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pot)1(en)-1(t)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.35100174 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.85100174 11.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.51100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.01100159 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.95200348 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.45200348 11.72200012 Tm [(vesic)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.70899963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.20899963 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.01600647 11.72200012 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.69299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.19299316 11.72200012 Tm [(mainly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.69999695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.19999695 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.64100647 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.64199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.14199829 11.72200012 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.81799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(sec)-1(reto)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.60400009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.10400009 27.3220005 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.73200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.23200226 27.3220005 Tm [(Cont)1(ributes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.62399292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.12399292 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.19900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.69900513 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.69999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.19999695 27.3220005 Tm [(couple)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.48699951 27.3220005 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.29699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.79699707 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.63900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.13900757 27.3220005 Tm [(TM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ED2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58200073 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.85900116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.35900116 42.92200089 Tm [(TMED10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.67099762 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.17099762 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.11199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.61199951 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.61299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.11299896 42.92200089 Tm [(ci)-1(s)1(-Go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.04200745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.54200745 42.92200089 Tm [(ne)-1(t)1(wo)1(rk)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.87800598 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 0.75 m 124.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 17.10000038 m 124.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 33.45000076 m 124.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 49.80000305 m 124.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 66.15000153 m 124.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 82.5 m 124.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 98.84999847 m 124.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 115.19999695 m 124.80000305 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 426.92498779 162.375 l S Q Q q 1 0 0 1 0 563.81799316 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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