%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.75900269 23.67700005 Tm 0 g [(TLE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.83599854 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 145.83599854 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 322.54000854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TL)-1(E1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.98000336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 88.23000336 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 172.22999573 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TL)-1(E1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.98000336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.35399628 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.55599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.93000031 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.91000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.28399658 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.75799561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transdu)-1(cin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.23000336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60399628 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.42099762 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.79499817 12.82499981 Tm [(enhan)-1(ce)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.92399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.29800415 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.03900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.41299438 12.82499981 Tm [(sp)-1(lit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.3730011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.74699402 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.87800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.2519989 12.82499981 Tm [(ES)-1(G;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.63699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.01100159 12.82499981 Tm [(ES)-1(G1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.71798706 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.0920105 12.82499981 Tm [(GRG1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.36300659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(571-7)1(70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(TL)-1(E1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 332.93099976 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansduc)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.23300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.73300171 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.52899933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.02899933 11.72200012 Tm [(en)-1(h)1(anc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.30000305 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.14199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.64199829 11.72200012 Tm [(split)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.19900513 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.477005 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ESG;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.00200081 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.50200081 11.72200012 Tm [(ESG1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.7820015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.2820015 11.72200012 Tm [(GR)1(G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.82099915 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q04)-1(72)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(74)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 140.4750061 16.35000038 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 139.7250061 0.75 l 139.7250061 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 140.7250061 -0.25 l 140.7250061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.4750061 0.75 m 426.17501831 0.75 l 426.17501831 109.94999695 l 140.4750061 109.94999695 l h f* Q q 1 0 0 1 140.1000061 0 cm -0.625 -0.25 m 287.07501221 -0.25 l 287.07501221 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Transcriptio)1(n)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.75999832 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.26000214 11.72200012 Tm [(corepressor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.81900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.31900024 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.54100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.04100037 11.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.65299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.15299988 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.22799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.72799683 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.70300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.20300293 11.72200012 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.51899719 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.36099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.86099243 11.72200012 Tm [(tr)1(ansc)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ipt)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.1590004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6590004 27.3220005 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.11100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.61100006 27.3220005 Tm [(Inhibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.40100098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.90100098 27.3220005 Tm [(NF-kapp)1(a-B-regulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.10400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.60400391 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.11999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.61999512 27.3220005 Tm [(expression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.73999023 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(Inhibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.79000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29000092 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.29100037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.79100037 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.74500275 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.24500275 42.92200089 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.19500732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.69500732 42.92200089 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.57699585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.07699585 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.58900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.08900452 42.92200089 Tm [(FOXA2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.7869873 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.2869873 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.7689991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.2689991 58.52199936 Tm [(CTNNB)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.00699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.50700378 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.78399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.28399658 58.52199936 Tm [(TCF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.24500275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.74500275 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.82699585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.32699585 58.52199936 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.75700378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.25700378 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.19799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.69799805 58.52199936 Tm [(Wnt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.75500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.25500488 58.52199936 Tm [(signaling.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.35299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.85299683 58.52199936 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(effec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.0909996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.5909996 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.43299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.93299866 74.12200165 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.98100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.48100281 74.12200165 Tm [(TLE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.20700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.70700073 74.12200165 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.78900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.28900146 74.12200165 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71899414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.21899414 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.38999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.88999939 74.12200165 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.7440033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.2440033 74.12200165 Tm [(mod)1(u)-1(la)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.375 89.72200012 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.30200195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.80200195 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.19799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.69799805 89.72200012 Tm [(do)1(mi)-1(na)1(n)-1(t)1(-negat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.27999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.77999878 89.72200012 Tm [(AE)1(S)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.42199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.92199707 89.72200012 Tm [(Unusual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.81500244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.31500244 89.72200012 Tm [(func)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.30400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.80400085 105.3219986 Tm [(coactivat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.48500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.98500061 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.76300049 105.3219986 Tm [(ESRRG)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.51600647 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 0.75 m 140.1000061 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 17.10000038 m 140.1000061 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 33.45000076 m 140.1000061 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 49.80000305 m 140.1000061 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 66.15000153 m 140.1000061 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 82.5 m 140.1000061 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 98.84999847 m 140.1000061 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.1000061 115.19999695 m 140.1000061 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92501831 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>